Journal article
Mother-to-child transmission in the United States of subtypes D and A/G human immunodeficiency virus type 1
AIDS research and human retroviruses, Vol.18(6), pp.413-417
2002
DOI: 10.1089/088922202753614173
PMID: 11958684
Abstract
In the United States and Western Europe, most human immunodeficiency virus type 1 (HIV-1) infections are caused by subtype B. We analyzed the nucleotide sequence of HIV-1 RNA in plasma samples from 141 children enrolled into PACTG 377, a comparative study of several antiretroviral therapy regimens. Phylogenetic analysis revealed that two children, both born in the United States, were infected with non-B subtypes that are most commonly found in Africa: one with subtype D and the other with circulating recombinant form CRF02, an A/G recombinant lineage. Viral load assays performed to monitor treatment response underestimated the levels of HIV-1 RNA in the child with the A/G recombinant. These cases demonstrate mother-to-child transmission of non-B subtypes of HIV-1 in the United States. Non-B subtypes should be considered in the management of HIV-1-infected pregnant women and children to optimize strategies to prevent and treat pediatric HIV-1 infection.
Details
- Title: Subtitle
- Mother-to-child transmission in the United States of subtypes D and A/G human immunodeficiency virus type 1
- Creators
- Paul KROGSTAD - Departments of Pediatrics and Molecular and Medical Pharmacology, University of California, Los Angeles School of Medicine, Los Angeles, California 90095, United StatesSusan H ESHLEMAN - Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, United StatesPaul PALUMBO - Department of Pediatrics, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, United StatesYongzhi Geng - Departments of Pediatrics and Molecular and Medical Pharmacology, University of California, Los Angeles School of Medicine, Los Angeles, California 90095, United StatesJ. Brooks JACKSON - Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, United StatesMichael WANTMAN - Statistical Data Analysis Center, Harvard School of Public Health, Boston, Massachusetts 02115, United StatesBette KORBER - Los Alamos National Laboratory, Santa Fe, New Mexico 87545, United StatesDorothy LANG - Los Alamos National Laboratory, Santa Fe, New Mexico 87545, United StatesAndrew WIZNIA - Department of Pediatrics, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, New York 10461, United StatesGeorge JOHNSON - Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, United StatesSharon NACHMAN - Department of Pediatrics, State University of New York at Stony Brook, Stony Brook, New York 11794, United States
- Resource Type
- Journal article
- Publication Details
- AIDS research and human retroviruses, Vol.18(6), pp.413-417
- Publisher
- Liebert; Larchmont, NY
- DOI
- 10.1089/088922202753614173
- PMID
- 11958684
- ISSN
- 0889-2229
- eISSN
- 1931-8405
- Language
- English
- Date published
- 2002
- Academic Unit
- Pathology; VPMA - Administration
- Record Identifier
- 9984047875902771
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