Mothers with substance addictions show reduced reward responses when viewing their own infant's face

Sohye Kim; Udita Iyengar; Linda C Mayes; Marc N Potenza; Helena J V Rutherford; Lane Strathearn

doi:10.1002/hbm.23731

Back

Mothers with substance addictions show reduced reward responses when viewing their own infant's face

Journal article

Open access

Peer reviewed

Mothers with substance addictions show reduced reward responses when viewing their own infant's face

Sohye Kim, Udita Iyengar, Linda C Mayes, Marc N Potenza, Helena J V Rutherford and Lane Strathearn

Human brain mapping, Vol.38(11), pp.5421-5439

11/2017

DOI: 10.1002/hbm.23731

PMCID: PMC5763911

PMID: 28746733

Files and links (1)

url

https://doi.org/10.1002/hbm.23731View

Published (Version of record) Open Access

Abstract

Maternal addiction constitutes a major public health problem affecting children, with high rates of abuse, neglect, and foster care placement. However, little is known about the ways in which substance addiction alters brain function related to maternal behavior. Prior studies have shown that infant face cues activate similar dopamine-associated brain reward regions to substances of abuse. Here, we report on a functional MRI study documenting that mothers with addictions demonstrate reduced activation of reward regions when shown reward-related cues of their own infants. Thirty-six mothers receiving inpatient treatment for substance addiction were scanned at 6 months postpartum, while viewing happy and sad face images of their own infant compared to those of a matched unknown infant. When viewing happy face images of their own infant, mothers with addictions showed a striking pattern of decreased activation in dopamine- and oxytocin-innervated brain regions, including the hypothalamus, ventral striatum, and ventromedial prefrontal cortex-regions in which increased activation has previously been observed in mothers without addictions. Our results are the first to demonstrate that mothers with addictions show reduced activation in key reward regions of the brain in response to their own infant's face cues. Hum Brain Mapp 38:5421-5439, 2017. © 2017 Wiley Periodicals, Inc.

Brain - diagnostic imaging

Mother-Child Relations - psychology

Brain - physiopathology

Facial Recognition - physiology

Humans

Middle Aged

Facial Expression

Infant

Male

Hospitalization

Postpartum Period

Substance-Related Disorders - therapy

Affect

Substance-Related Disorders - physiopathology

Mothers - psychology

Young Adult

Magnetic Resonance Imaging

Brain Mapping

Substance-Related Disorders - psychology

Adult

Female

Reward

Substance-Related Disorders - diagnostic imaging

Details

Title: Subtitle: Mothers with substance addictions show reduced reward responses when viewing their own infant's face
Creators: Sohye Kim - Center for Reproductive Psychiatry, Pavilion for Women, Texas Children's Hospital, Houston, Texas, United States
Udita Iyengar - Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom
Linda C Mayes - Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut, United States
Marc N Potenza - Connecticut Mental Health Center, New Haven, Connecticut, United States
Helena J V Rutherford - Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut, United States
Lane Strathearn - Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States
Resource Type: Journal article
Publication Details: Human brain mapping, Vol.38(11), pp.5421-5439
DOI: 10.1002/hbm.23731
PMID: 28746733
PMCID: PMC5763911
NLM abbreviation: Hum Brain Mapp
ISSN: 1065-9471
eISSN: 1097-0193
Publisher: United States
Grant note: K23 HD043097 / NICHD NIH HHS R03 HD080998 / NICHD NIH HHS UL1 TR001863 / NCATS NIH HHS R01 DA006025 / NIDA NIH HHS R01 DA039136 / NIDA NIH HHS R01 HD065819 / NICHD NIH HHS R01 DA026437 / NIDA NIH HHS
Language: English
Date published: 11/2017
Academic Unit: Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Developmental and Behavioral Pediatrics; Neuroscience and Pharmacology
Record Identifier: 9984040353902771

Metrics

9 Record Views

56 Times Cited - Web of Science