Journal article
Motor Abnormalities in Premanifest Persons with Huntington’s Disease: The PREDICT-HD Study
Movement disorders, Vol.24(12), pp.1763-1772
09/15/2009
DOI: 10.1002/mds.22601
PMCID: PMC3048804
PMID: 19562761
Abstract
The PREDICT-HD study seeks to identify clinical and biological markers of Huntington's disease in premanifest individuals who have undergone predictive genetic testing. We compared baseline motor data between gene-expansion carriers (cases) and nongene-expansion carriers (controls) using t-tests and Chi-square. Cases were categorized as near, mid, or far from diagnosis using a CAG-based formula. Striatal volumes were calculated using volumetric magnetic resonance imaging measurements. Multiple linear regression associated total motor score, motor domains, and individual motor items with estimated diagnosis and striatal volumes. Elevated total motor scores at baseline were associated with higher genetic probability of disease diagnosis in the near future (partial R(2) 0.14, P < 0.0001) and smaller striatal volumes (partial R(2) 0.15, P < 0.0001). Nearly all motor domain scores showed greater abnormality with increasing proximity to diagnosis, although bradykinesia and chorea were most highly associated with diagnostic immediacy. Among individual motor items, worse scores on finger tapping, tandem gait, Luria, saccade initiation, and chorea show unique association with diagnosis probability. Even in this premanifest population, subtle motor abnormalities were associated with a higher probability of disease diagnosis and smaller striatal volumes. Longitudinal assessment will help inform whether motor items will be useful measures in preventive clinical trials.
Details
- Title: Subtitle
- Motor Abnormalities in Premanifest Persons with Huntington’s Disease: The PREDICT-HD Study
- Creators
- Kevin M Biglan - Kessler Medical Rehabilitation Research & Education Center, West Orange, New JerseyChristopher A Ross - Kessler Medical Rehabilitation Research & Education Center, West Orange, New JerseyDouglas R Langbehn - Kessler Medical Rehabilitation Research & Education Center, West Orange, New JerseyElizabeth H Aylward - Kessler Medical Rehabilitation Research & Education Center, West Orange, New JerseyJulie C Stout - Kessler Medical Rehabilitation Research & Education Center, West Orange, New JerseySarah Queller - Kessler Medical Rehabilitation Research & Education Center, West Orange, New JerseyNoelle E Carlozzi - Kessler Medical Rehabilitation Research & Education Center, West Orange, New JerseyKevin Duff - Kessler Medical Rehabilitation Research & Education Center, West Orange, New JerseyLeigh J Beglinger - Kessler Medical Rehabilitation Research & Education Center, West Orange, New JerseyJane S Paulsen - Kessler Medical Rehabilitation Research & Education Center, West Orange, New JerseyHuntington Study Group
- Contributors
- Hans J Johnson (Contributor) - University of Iowa, Electrical and Computer Engineering
- Resource Type
- Journal article
- Publication Details
- Movement disorders, Vol.24(12), pp.1763-1772
- DOI
- 10.1002/mds.22601
- PMID
- 19562761
- PMCID
- PMC3048804
- NLM abbreviation
- Mov Disord
- ISSN
- 0885-3185
- eISSN
- 1531-8257
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: NS40068; name: CHDI, Inc; name: Douglas Langbehn at The University of Iowa
- Language
- English
- Date published
- 09/15/2009
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; The Iowa Institute for Biomedical Imaging; The Iowa Initiative for Artificial Intelligence; Iowa Informatics Initiative
- Record Identifier
- 9984003423402771
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