Journal article
Motor neuron disease and plasma cell dyscrasia
Neurology, Vol.36(11), pp.1429-1436
1986
DOI: 10.1212/WNL.36.11.1429
PMID: 3762961
Abstract
In the years 1977 to 1984, 10 of 206 patients (4.8%) with motor neuron disease (MND) had M proteins; 4 had IgM and 6 had IgG. Among 100 control patients with other neurologic diseases, only 1 had an M protein. We later added six cases of MND and M proteins, as well as three with polyclonal IgM elevations and two with Bence-Jones proteins. Including other reports, there are now 37 known cases of MND with monoclonal and 5 with polyclonal gammopathy. There is evidence that plasma cell dyscrasia is often undetected; the actual incidence of serum immunoglobulin abnormality in patients with MND may be greater than our figure.
Details
- Title: Subtitle
- Motor neuron disease and plasma cell dyscrasia
- Creators
- M. E SHY - Columbia univ., coll. physicians surgeons, United StatesL. P ROWLAND - Columbia univ., coll. physicians surgeons, United StatesT SMITH - Columbia univ., coll. physicians surgeons, United StatesW TROJABORG - Columbia univ., coll. physicians surgeons, United StatesN LATOV - Columbia univ., coll. physicians surgeons, United StatesW SHERMAN - Columbia univ., coll. physicians surgeons, United StatesM. A PESCE - Columbia univ., coll. physicians surgeons, United StatesR. E LOVELACE - Columbia univ., coll. physicians surgeons, United StatesE. F OSSERMAN - Columbia univ., coll. physicians surgeons, United States
- Resource Type
- Journal article
- Publication Details
- Neurology, Vol.36(11), pp.1429-1436
- Publisher
- Lippincott Williams & Wilkins; Hagerstown, MD
- DOI
- 10.1212/WNL.36.11.1429
- PMID
- 3762961
- ISSN
- 0028-3878
- eISSN
- 1526-632X
- Language
- English
- Date published
- 1986
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
- Record Identifier
- 9984020994402771
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