Journal article
Motor timing variability increases in preclinical Huntington's disease patients as estimated onset of motor symptoms approaches
Journal of the International Neuropsychological Society, Vol.13(3), pp.539-543
05/2007
DOI: 10.1017/S1355617707070671
PMID: 17445303
Abstract
Huntington's disease (HD) is a neurodegenerative disorder
diagnosed clinically with the development of choreiform movements.
However, neuropsychological studies have demonstrated cognitive and
psychiatric changes during the preclinical phase (pre-HD) prior to formal
diagnosis. Previous studies have demonstrated the sensitivity of time
reproduction tasks to basal ganglia pathology, as seen in clinical HD and
Parkinson's disease. In this study, 29 pre-HD participants, ranging
from 3 to 39 years from estimated onset (YEO) of HD based on genetic
testing and chronological age, were administered the paced finger-tapping
task using target intervals of 600 and 1200 ms. Mean inter-response
interval, a measure of timing accuracy, did not systematically deviate
from the target interval as a function of YEO. In contrast, timing
variability increased curvilinearly as a function of YEO, but not with
chronological age alone. Motor timing variability, but not accuracy, may
serve as a marker to define the earliest behavioral changes in HD. The
present study is among the first to examine the relationship between
behavioral measures and YEO in pre-HD. (JINS, 2007, 13,
539–543.)
Details
- Title: Subtitle
- Motor timing variability increases in preclinical Huntington's disease patients as estimated onset of motor symptoms approaches
- Creators
- SEAN C HINTON - Department of Neurology, Medical College of Wisconsin, Milwaukee, WisconsinJANE S PAULSEN - Departments of Psychiatry and Neurology, University of Iowa, Iowa City, IowaRAYMOND G HOFFMANN - Division of Biostatistics, Medical College of Wisconsin, Milwaukee, WisconsinNORMAN C REYNOLDS - Department of Neurology, Medical College of Wisconsin, Milwaukee, WisconsinJANICE L ZIMBELMAN - Department of Neurology, Medical College of Wisconsin, Milwaukee, WisconsinSTEPHEN M RAO - Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin
- Resource Type
- Journal article
- Publication Details
- Journal of the International Neuropsychological Society, Vol.13(3), pp.539-543
- Publisher
- Cambridge University Press
- DOI
- 10.1017/S1355617707070671
- PMID
- 17445303
- ISSN
- 1355-6177
- eISSN
- 1469-7661
- Number of pages
- 5
- Language
- English
- Date published
- 05/2007
- Academic Unit
- Psychiatry; Psychological and Brain Sciences
- Record Identifier
- 9984083204702771
Metrics
14 Record Views