Journal article
Mouse allergen exposure and decreased risk of allergic rhinitis in school-aged children
Annals of allergy, asthma, & immunology, Vol.113(6), pp.614-618.e2
12/2014
DOI: 10.1016/j.anai.2014.09.007
PMCID: PMC4256145
PMID: 25304339
Abstract
Little is known about exposure to mouse allergen (Mus m 1) and allergic rhinitis (AR).
To evaluate the association between mouse allergen exposure and AR in children.
We examined the relation between mouse allergen level in house dust and AR in 511 children aged 6 to 14 years in San Juan, Puerto Rico. Study participants were chosen from randomly selected households using a multistage probability sample design. The study protocol included questionnaires, allergy skin testing, and collection of blood and dust samples. AR was defined as current rhinitis symptoms and skin test reactivity to at least one allergen.
In the multivariate analyses, mouse allergen level was associated with a 25% decreased odds of AR in participating children (95% confidence interval, 0.62-0.92). Although endotoxin and mouse allergen levels were significantly correlated (r = 0.184, P < .001), the observed inverse association between Mus m 1 and AR was not explained by levels of endotoxin or other markers of microbial or fungal exposure (peptidoglycan and glucan).
Mouse allergen exposure is associated with decreased odds of AR in Puerto Rican school-aged children.
Details
- Title: Subtitle
- Mouse allergen exposure and decreased risk of allergic rhinitis in school-aged children
- Creators
- Tammy S Jacobs - Division of Pediatric Pulmonary Medicine, Allergy and Immunology, Children's Hospital of Pittsburgh of University of Pittsburgh, Pittsburgh, PennsylvaniaErick Forno - Division of Pediatric Pulmonary Medicine, Allergy and Immunology, Children's Hospital of Pittsburgh of University of Pittsburgh, Pittsburgh, PennsylvaniaJohn M Brehm - Division of Pediatric Pulmonary Medicine, Allergy and Immunology, Children's Hospital of Pittsburgh of University of Pittsburgh, Pittsburgh, PennsylvaniaEdna Acosta-Pérez - Behavioral Sciences Research Institute, University of Puerto Rico, San Juan, Puerto RicoYueh-Ying Han - Division of Pediatric Pulmonary Medicine, Allergy and Immunology, Children's Hospital of Pittsburgh of University of Pittsburgh, Pittsburgh, PennsylvaniaJoshua Blatter - Division of Pediatric Pulmonary Medicine, Allergy and Immunology, Children's Hospital of Pittsburgh of University of Pittsburgh, Pittsburgh, PennsylvaniaPeter Thorne - Department of Occupational and Environmental Health, University of Iowa College of Public Health, University of Iowa, Iowa City, IowaNervana Metwali - Department of Occupational and Environmental Health, University of Iowa College of Public Health, University of Iowa, Iowa City, IowaAngel Colón-Semidey - Behavioral Sciences Research Institute, University of Puerto Rico, San Juan, Puerto RicoMaría Alvarez - Behavioral Sciences Research Institute, University of Puerto Rico, San Juan, Puerto RicoGlorisa Canino - Behavioral Sciences Research Institute, University of Puerto Rico, San Juan, Puerto RicoJuan C Celedón - Division of Pediatric Pulmonary Medicine, Allergy and Immunology, Children's Hospital of Pittsburgh of University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address: juan.celedon@chp.edu
- Resource Type
- Journal article
- Publication Details
- Annals of allergy, asthma, & immunology, Vol.113(6), pp.614-618.e2
- DOI
- 10.1016/j.anai.2014.09.007
- PMID
- 25304339
- PMCID
- PMC4256145
- NLM abbreviation
- Ann Allergy Asthma Immunol
- ISSN
- 1081-1206
- eISSN
- 1534-4436
- Publisher
- Elsevier BV; United States
- Grant note
- HL079966 / NHLBI NIH HHS R01 HL079966 / NHLBI NIH HHS R01 HL117191 / NHLBI NIH HHS HD052892 / NICHD NIH HHS HL117191 / NHLBI NIH HHS K12 HD052892 / NICHD NIH HHS
- Language
- English
- Date published
- 12/2014
- Academic Unit
- Civil and Environmental Engineering; Occupational and Environmental Health
- Record Identifier
- 9983997448502771
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