Mouse hepatitis virus does not induce Beta interferon synthesis and does not inhibit its induction by double-stranded RNA

Haixia Zhou; Stanley Perlman

doi:10.1128/JVI.01512-06

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Mouse hepatitis virus does not induce Beta interferon synthesis and does not inhibit its induction by double-stranded RNA

Journal article

Open access

Peer reviewed

Mouse hepatitis virus does not induce Beta interferon synthesis and does not inhibit its induction by double-stranded RNA

Haixia Zhou and Stanley Perlman

Journal of virology, Vol.81(2), pp.568-574

01/2007

DOI: 10.1128/JVI.01512-06

PMCID: PMC1797428

PMID: 17079305

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Abstract

Mouse hepatitis virus (MHV) does not induce interferon (IFN) production in fibroblasts or bone marrow-derived dendritic cells. In this report, we show that the essential IFN-beta transcription factors NF-kappaB and IFN regulatory factor 3 are not activated for nuclear translocation and gene induction during infection. However, MHV was unable to inhibit the activation of these factors and subsequent IFN-beta production induced by poly(I:C). Further, MHV infection did not inhibit IFN-beta production mediated by known host pattern recognition receptors (PRRs) (RIG-I, Mda-5, and TLR3). These results are consistent with the notion that double-stranded RNA, produced during MHV infection, is not accessible to cellular PRRs.

Humans

Transcriptional Activation

NF-kappa B - metabolism

Interferon Regulatory Factor-3 - genetics

Interferon-Induced Helicase, IFIH1

Murine hepatitis virus - immunology

Membrane Proteins - metabolism

RNA, Double-Stranded - metabolism

Toll-Like Receptor 3 - genetics

DEAD-box RNA Helicases - metabolism

Cell Line

Poly I-C - pharmacology

Membrane Proteins - genetics

Gene Expression Regulation

Interferon-beta - biosynthesis

Murine hepatitis virus - pathogenicity

Toll-Like Receptor 3 - metabolism

Nerve Tissue Proteins - genetics

Nerve Tissue Proteins - metabolism

DEAD-box RNA Helicases - genetics

Animals

NF-kappa B - genetics

RNA, Double-Stranded - genetics

RNA, Double-Stranded - immunology

Interferon Regulatory Factor-3 - metabolism

Mice

Murine hepatitis virus - classification

Details

Title: Subtitle: Mouse hepatitis virus does not induce Beta interferon synthesis and does not inhibit its induction by double-stranded RNA
Creators: Haixia Zhou - Department of Microbiology, University of Iowa, Bowen Science Building 3-730, Iowa City, IA 52242, USA
Stanley Perlman
Resource Type: Journal article
Publication Details: Journal of virology, Vol.81(2), pp.568-574
DOI: 10.1128/JVI.01512-06
PMID: 17079305
PMCID: PMC1797428
NLM abbreviation: J Virol
ISSN: 0022-538X
eISSN: 1098-5514
Publisher: United States
Grant note: R01 NS036592 / NINDS NIH HHS NS036592 / NINDS NIH HHS
Language: English
Date published: 01/2007
Academic Unit: Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
Record Identifier: 9983777473802771

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