Moyamoya syndrome causing stroke in young women with type 1 diabetes

Jing W Hughes; Jennifer A Wyckoff; Abby S Hollander; Colin P Derdeyn; Janet B McGill

doi:10.1016/j.jdiacomp.2016.08.004

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Moyamoya syndrome causing stroke in young women with type 1 diabetes

Journal article

Peer reviewed

Moyamoya syndrome causing stroke in young women with type 1 diabetes

Jing W Hughes, Jennifer A Wyckoff, Abby S Hollander, Colin P Derdeyn and Janet B McGill

Journal of diabetes and its complications, Vol.30(8), pp.1640-1642

11/2016

DOI: 10.1016/j.jdiacomp.2016.08.004

PMCID: PMC5050134

PMID: 27592246

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https://www.ncbi.nlm.nih.gov/pmc/articles/5050134View

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Abstract

Moyamoya syndrome is an idiopathic brain vasculopathy characterized by stenosis of major intracranial arteries. It often presents in patients with type 1 diabetes or thyroid disease and may have an autoimmune etiology. Moyamoya-related stroke poses a diagnostic challenge as initial symptoms and deficits vary greatly from classic ischemic stroke to encephalopathy, psychiatric, or seizure disorder. We report 4 patients with type 1 diabetes and other autoimmune diseases who developed moyamoya-related stroke at a young age. Despite having long-term diabetes, these patients exhibited no evidence of dyslipidemia or other typical risk factors for atherosclerosis which might contribute to premature stroke. Three of the four patients underwent revascularization surgery while one patient received conservative management. All patients had improved neurologic function after treatment, some with residual deficits. We highlight the importance of recognizing moyamoya syndrome in patients with pre-existing autoimmune diseases such as type 1 diabetes, as prompt diagnosis and treatment can have major impact on patient outcome and quality of life.

Autoimmunity

Stroke

Vasculopathy

Type 1 diabetes

Moyamoya

Details

Title: Subtitle: Moyamoya syndrome causing stroke in young women with type 1 diabetes
Creators: Jing W Hughes - Division of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA
Jennifer A Wyckoff - Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, USA
Abby S Hollander - Division of Pediatric Endocrinology and Metabolism, Washington University School of Medicine, St. Louis, MO, USA
Colin P Derdeyn - Division of Diagnostic Radiology, Neuroradiology Section, Washington University School of Medicine, St. Louis, MO, USA
Janet B McGill - Division of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA
Resource Type: Journal article
Publication Details: Journal of diabetes and its complications, Vol.30(8), pp.1640-1642
DOI: 10.1016/j.jdiacomp.2016.08.004
PMID: 27592246
PMCID: PMC5050134
NLM abbreviation: J Diabetes Complications
ISSN: 1056-8727
eISSN: 1873-460X
Publisher: Elsevier Inc
Grant note: DOI: 10.13039/100000002, name: NIH, award: R01NS51631
Language: English
Date published: 11/2016
Academic Unit: Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
Record Identifier: 9984013205802771

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