Journal article
MuDeRN: Multi-category classification of breast histopathological image using deep residual networks
Artificial intelligence in medicine, Vol.88, pp.14-24
06/2018
DOI: 10.1016/j.artmed.2018.04.005
PMID: 29705552
Abstract
•MuDeRN is a framework using deep residual network for classifying H&E breast digital.•MuDeRN classifies patients as benign or cancer with accuracy of 98.77%.•It classifies benign images into four subtypes with accuracy of adenosis, fibroadenoma, phyllodes tumor, or tubular adenoma.•It classifies malignant images as ductal carcinoma, lobular carcinoma, mucinous carcinoma, or papillary carcinoma.•MuDeRN achieved patient-level accuracy of 96.25% for eight-class categorization.
Identifying carcinoma subtype can help to select appropriate treatment options and determining the subtype of benign lesions can be beneficial to estimate the patients’ risk of developing cancer in the future. Pathologists’ assessment of lesion subtypes is considered as the gold standard, however, sometimes strong disagreements among pathologists for distinction among lesion subtypes have been previously reported in the literature.
To propose a framework for classifying hematoxylin-eosin stained breast digital slides either as benign or cancer, and then categorizing cancer and benign cases into four different subtypes each.
We used data from a publicly available database (BreakHis) of 81 patients where each patient had images at four magnification factors (×40, ×100, ×200, and ×400) available, for a total of 7786 images. The proposed framework, called MuDeRN (MUlti-category classification of breast histopathological image using DEep Residual Networks) consisted of two stages. In the first stage, for each magnification factor, a deep residual network (ResNet) with 152 layers has been trained for classifying patches from the images as benign or malignant. In the next stage, the images classified as malignant were subdivided into four cancer subcategories and those categorized as benign were classified into four subtypes. Finally, the diagnosis for each patient was made by combining outputs of ResNets’ processed images in different magnification factors using a meta-decision tree.
For the malignant/benign classification of images, MuDeRN’s first stage achieved correct classification rates (CCR) of 98.52%, 97.90%, 98.33%, and 97.66% in ×40, ×100, ×200, and ×400 magnification factors respectively. For eight-class categorization of images based on the output of MuDeRN’s both stages, CCRs in four magnification factors were 95.40%, 94.90%, 95.70%, and 94.60%. Finally, for making patient-level diagnosis, MuDeRN achieved a CCR of 96.25% for eight-class categorization.
MuDeRN can be helpful in the categorization of breast lesions.
Details
- Title: Subtitle
- MuDeRN: Multi-category classification of breast histopathological image using deep residual networks
- Creators
- Ziba Gandomkar - Image Optimisation and Perception, Discipline of Medical Imaging and Radiation Sciences, Faculty of Health Sciences, University of Sydney, Sydney, NSW, AustraliaPatrick C Brennan - Image Optimisation and Perception, Discipline of Medical Imaging and Radiation Sciences, Faculty of Health Sciences, University of Sydney, Sydney, NSW, AustraliaClaudia Mello-Thoms - Image Optimisation and Perception, Discipline of Medical Imaging and Radiation Sciences, Faculty of Health Sciences, University of Sydney, Sydney, NSW, Australia
- Resource Type
- Journal article
- Publication Details
- Artificial intelligence in medicine, Vol.88, pp.14-24
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.artmed.2018.04.005
- PMID
- 29705552
- ISSN
- 0933-3657
- eISSN
- 1873-2860
- Language
- English
- Date published
- 06/2018
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology
- Record Identifier
- 9984051720902771
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