Mucinous tumors of the ovary: interobserver diagnostic variability and utility of sectioning protocols

S S Raab; R A Robinson; C S Jensen; D Ozkutlu; P O O'Reilly; V H Savell; P A Thomas

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Mucinous tumors of the ovary: interobserver diagnostic variability and utility of sectioning protocols

Journal article

Peer reviewed

Mucinous tumors of the ovary: interobserver diagnostic variability and utility of sectioning protocols

S S Raab, R A Robinson, C S Jensen, D Ozkutlu, P O O'Reilly, V H Savell and P A Thomas

Archives of pathology & laboratory medicine (1976), Vol.121(11), pp.1192-1198

11/1997

PMID: 9372748

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Abstract

To determine the interobserver variability of the subclassification of ovarian mucinous tumors and the utility of different sectioning protocols. Six pathologists retrospectively reclassified 73 mucinous tumors (30 adenomas, 22 low malignant potential tumors, and 21 carcinomas). Using probabilities, the accuracy of limited sectioning protocols was compared with that of a one section per centimeter protocol. The mean kappa statistic was 0.56, indicating only good agreement. Although a limited sectioning protocol would result in misdiagnosing cases of stage IA carcinoma as a low malignant potential tumor, the overall prognosis of patients with low malignant potential tumors would not markedly change. The prognosis of a patient with a low malignant potential tumor using limited sectioning was within the prognostic range owing to interobserver variability alone. We conclude that extensive sectioning of ovarian mucinous tumors has limited benefit.

Diagnosis, Differential

Prognosis

Adenocarcinoma, Mucinous - pathology

Humans

Middle Aged

Ovarian Neoplasms - pathology

Probability

Random Allocation

Tissue Embedding

Adenocarcinoma, Mucinous - epidemiology

Ovarian Neoplasms - epidemiology

Cystadenoma, Mucinous - pathology

Ovarian Neoplasms - classification

Adult

Female

Aged

Cystadenoma, Mucinous - epidemiology

Retrospective Studies

Adenocarcinoma, Mucinous - classification

Cystadenoma, Mucinous - classification

Observer Variation

Details

Title: Subtitle: Mucinous tumors of the ovary: interobserver diagnostic variability and utility of sectioning protocols
Creators: S S Raab - Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City 52241-1009, USA
R A Robinson
C S Jensen
D Ozkutlu
P O O'Reilly
V H Savell
P A Thomas
Resource Type: Journal article
Publication Details: Archives of pathology & laboratory medicine (1976), Vol.121(11), pp.1192-1198
Publisher: United States
PMID: 9372748
ISSN: 0003-9985
eISSN: 1543-2165
Language: English
Date published: 11/1997
Academic Unit: Oral Pathology, Radiology and Medicine; Pathology
Record Identifier: 9984046807102771

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11 Times Cited - Web of Science