Journal article
Mucocutaneous Granulomatous Disease in a Patient With Hermansky-Pudlak Syndrome
JAMA dermatology (Chicago, Ill.), Vol.150(10), pp.1083-1087
10/01/2014
DOI: 10.1001/jamadermatol.2014.147
PMID: 24989352
Abstract
IMPORTANCE Hermansky-Pudlak syndrome (HPS) is a rare genodermatosis characterized by oculocutaneous albinism, platelet dysfunction, and in some patients, pulmonary fibrosis and granulomatous colitis. The granulomatous inflammation in the bowel of patients with HPS can be indistinguishable clinically and histologically from that of Crohn disease (CD); however, mucocutaneous granulomatous lesions have not been considered among the typical skin findings of HPS.
\OBSERVATIONS We report a case of an albino woman in her 40s with a history of CD and pulmonary fibrosis who presented with ulcers, plaques, and nodules in the vulva, perineum, inguinal creases, and left axilla. These cutaneous findings had the typical clinical and histologic findings of metastatic cutaneous CD. However, she also had a genetically confirmed diagnosis of HPS.
CONCLUSIONS AND RELEVANCE It is unclear whether our patient's cutaneous findings were due to CD or secondary to HPS. This report reviews the features of HPS and CD, 2 entities characterized by a granulomatous inflammatory reaction pattern but with unique genetic and clinical features, and discusses the possible overlap between the 2 diagnoses.
Details
- Title: Subtitle
- Mucocutaneous Granulomatous Disease in a Patient With Hermansky-Pudlak Syndrome
- Creators
- Heather L. Salvaggio - Bassett Healthcare NetworkKristen E. Graeber - Pennsylvania State UniversityLoren E. Clarke - Dermatology Unit, Myriad Genetics Inc, Salt Lake City, Utah.Bethanee J. Schlosser - Northwestern UniversitySeth J. Orlow - New York UniversityJennie T. Clarke - Penn State Milton S. Hershey Medical Center
- Resource Type
- Journal article
- Publication Details
- JAMA dermatology (Chicago, Ill.), Vol.150(10), pp.1083-1087
- Publisher
- Amer Medical Assoc
- DOI
- 10.1001/jamadermatol.2014.147
- PMID
- 24989352
- ISSN
- 2168-6068
- eISSN
- 2168-6084
- Number of pages
- 5
- Language
- English
- Date published
- 10/01/2014
- Academic Unit
- Dermatology; Stead Family Department of Pediatrics
- Record Identifier
- 9984296308702771
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