Mucosal Leishmaniasis in Travelers with Leishmania braziliensis Complex Returning to Israel

Michal Solomon; Nadav Sahar; Felix Pavlotzky; Aviv Barzilai; Charles L. Jaffe; Abedelmajeed Nasereddin; Eli Schwartz

doi:10.3201/eid2504.180239

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Mucosal Leishmaniasis in Travelers with Leishmania braziliensis Complex Returning to Israel

Journal article

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Mucosal Leishmaniasis in Travelers with Leishmania braziliensis Complex Returning to Israel

Michal Solomon, Nadav Sahar, Felix Pavlotzky, Aviv Barzilai, Charles L. Jaffe, Abedelmajeed Nasereddin and Eli Schwartz

Emerging infectious diseases, Vol.25(4), pp.642-648

04/01/2019

DOI: 10.3201/eid2504.180239

PMCID: PMC6433024

PMID: 30882319

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Abstract

Mucosal leishmaniasis (ML) is a complication of New World cutaneous leishmaniasis (CL) caused mainly by Leishmania (Viannia) braziliensis. This retrospective study investigated all cases of ML caused by L. (V) braziliensis in a tertiary medical center in Israel, evaluating the risk factors, clinical presentations, diagnosis, treatment, and outcome of mucosal involvement in ML caused by L. (V) braziliensis in travelers returning to Israel. During 1993-2015, a total of 145 New World CL cases were seen in travelers returning from Bolivia; among them, 17 (11.7%) developed ML. Nasopharyngeal symptoms developed 0-3 years (median 8 months) after exposure. The only significant risk factor for developing ML was the absence of previous systemic treatment. Among untreated patients, 41% developed ML, compared with only 3% of treated patients (p = 0.005). Systemic treatment for CL seems to be a protective factor against developing ML.

Immunology

Infectious Diseases

Life Sciences & Biomedicine

Science & Technology

Details

Title: Subtitle: Mucosal Leishmaniasis in Travelers with Leishmania braziliensis Complex Returning to Israel
Creators: Michal Solomon - Sheba Medical Center
Nadav Sahar - Sheba Medical Center
Felix Pavlotzky - Sheba Medical Center
Aviv Barzilai - Sheba Medical Center
Charles L. Jaffe - Hebrew University of Jerusalem
Abedelmajeed Nasereddin - Hebrew University of Jerusalem
Eli Schwartz - Sheba Medical Center
Resource Type: Journal article
Publication Details: Emerging infectious diseases, Vol.25(4), pp.642-648
DOI: 10.3201/eid2504.180239
PMID: 30882319
PMCID: PMC6433024
NLM abbreviation: Emerg Infect Dis
ISSN: 1080-6040
eISSN: 1080-6059
Publisher: Centers Disease Control & Prevention
Number of pages: 7
Grant note: Michael and Penny Feiwel Chair of Dermatology
Language: English
Date published: 04/01/2019
Academic Unit: Gastroenterology and Hepatology; Internal Medicine
Record Identifier: 9984359862902771

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