Mucosal vaccines against respiratory syncytial virus

Kejian Yang; Steven M Varga

doi:10.1016/j.coviro.2014.03.009

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Mucosal vaccines against respiratory syncytial virus

Journal article

Peer reviewed

Mucosal vaccines against respiratory syncytial virus

Kejian Yang and Steven M Varga

Current opinion in virology, Vol.6(1), pp.78-84

06/2014

DOI: 10.1016/j.coviro.2014.03.009

PMCID: PMC4079457

PMID: 24794644

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https://www.ncbi.nlm.nih.gov/pmc/articles/4079457View

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Abstract

Respiratory syncytial virus (RSV) is a leading cause of severe respiratory disease in infants, young children, immune-compromised and elderly populations worldwide. Natural RSV infection in young children does not elicit long-lasting immunity and individuals remain susceptible to repeated RSV infections throughout life. Because RSV infection is restricted to the respiratory tract, an RSV vaccine should elicit mucosal immunity at upper and lower respiratory tracts in order to most effectively prevent RSV reinfection. Although there is no safe and effective RSV vaccine available, significant progress has been recently made in basic RSV research and vaccine development. This review will discuss recent advances in the identification of a new neutralizing antigenic site within the RSV fusion (F) protein, understanding the importance of mucosal immune responses against RSV infection, and the development of novel mucosal vaccination strategies.

Immunization

Respiratory Syncytial Virus Vaccines - immunology

Mucous Membrane - virology

Humans

Respiratory Syncytial Viruses - immunology

Immunity, Mucosal

Respiratory Syncytial Virus Infections - immunology

Antigens, Viral - immunology

Animals

Mucous Membrane - immunology

Respiratory Syncytial Virus Vaccines - administration & dosage

Respiratory Syncytial Virus Infections - prevention & control

Respiratory Syncytial Virus Infections - virology

Details

Title: Subtitle: Mucosal vaccines against respiratory syncytial virus
Creators: Kejian Yang - Biomedical Research Models Inc., 10 New Bond Street, Worcester, MA 01606, USA. Electronic address: KYang@biomere.com
Steven M Varga - Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA; Department of Pathology, University of Iowa, Iowa City, IA 52242, USA; Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
Resource Type: Journal article
Publication Details: Current opinion in virology, Vol.6(1), pp.78-84
DOI: 10.1016/j.coviro.2014.03.009
PMID: 24794644
PMCID: PMC4079457
NLM abbreviation: Curr Opin Virol
ISSN: 1879-6257
eISSN: 1879-6265
Grant note: CCR922413 / PHS HHS R01 AI063520 / NIAID NIH HHS R56 AI106776 / NIAID NIH HHS AI063820 / NIAID NIH HHS R43 AI063820 / NIAID NIH HHS AI102292 / NIAID NIH HHS R43 AI102292 / NIAID NIH HHS CCR924378 / PHS HHS R44 AI063820 / NIAID NIH HHS
Language: English
Date published: 06/2014
Academic Unit: Graduate College Admin and Gen; Microbiology and Immunology; Pathology
Record Identifier: 9984083878902771

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