Journal article
Mucus Plugs Persist in Asthma, and Changes in Mucus Plugs Associate with Changes in Airflow over Time
American journal of respiratory and critical care medicine, Vol.205(9), pp.1036-1045
05/01/2022
DOI: 10.1164/rccm.202110-2265OC
PMCID: PMC9851493
PMID: 35104436
Abstract
Cross-sectional analysis of mucus plugs in computed tomography (CT) lung scans in the Severe Asthma Research Program (SARP)-3 showed a high mucus plug phenotype.
To determine if mucus plugs are a persistent asthma phenotype and if changes in mucus plugs over time associate with changes in lung function.
In a longitudinal analysis of baseline and Year 3 CT lung scans in SARP-3 participants, radiologists generated mucus plug scores to assess mucus plug persistence over time. Changes in mucus plug score were analyzed in relation to changes in lung function and CT air trapping measures.
In 164 participants, the mean (range) mucus plug score was similar at baseline and Year 3 (3.4 [0-20] vs. 3.8 [0-20]). Participants and bronchopulmonary segments with a baseline plug were more likely to have plugs at Year 3 than those without baseline plugs (risk ratio, 2.8; 95% confidence interval [CI], 2.0-4.1;
< 0.001; and risk ratio, 5.0; 95% CI, 4.5-5.6;
< 0.001, respectively). The change in mucus plug score from baseline to Year 3 was significantly negatively correlated with change in FEV
% predicted (
= -0.35;
< 0.001) and with changes in CT air trapping measures (all
values < 0.05).
Mucus plugs identify a persistent asthma phenotype, and susceptibility to mucus plugs occurs at the subject and the bronchopulmonary segment level. The association between change in mucus plug score and change in airflow over time supports a causal role for mucus plugs in mechanisms of airflow obstruction in asthma.
Details
- Title: Subtitle
- Mucus Plugs Persist in Asthma, and Changes in Mucus Plugs Associate with Changes in Airflow over Time
- Creators
- Monica Tang - University of California, San FranciscoBrett M Elicker - University of California, San FranciscoTravis Henry - Duke UniversityDavid S Gierada - Washington University in St. Louis School of MedicineMark L Schiebler - University of Wisconsin–MadisonBrendan K Huang - University of California, San FranciscoMichael C Peters - University of California, San FranciscoMario Castro - University of KansasEric A Hoffman - University of IowaSean B Fain - University of IowaSamuel Y Ash - Brigham and Women's HospitalJiwoong Choi - University of KansasChase Hall - University of KansasBrenda R Phillips - Pennsylvania State UniversityDavid T Mauger - Penn State Milton S. Hershey Medical CenterLoren C Denlinger - University of Wisconsin–MadisonNizar N Jarjour - University of Wisconsin–MadisonElliot Israel - Brigham and Women's HospitalWanda Phipatanakul - Boston Children's HospitalBruce D Levy - Brigham and Women's HospitalSally E Wenzel - University of PittsburghEugene R Bleecker - University of ArizonaPrescott G Woodruff - University of California, San FranciscoJohn V Fahy - University of California, San FranciscoEleanor M Dunican - University College Dublin
- Resource Type
- Journal article
- Publication Details
- American journal of respiratory and critical care medicine, Vol.205(9), pp.1036-1045
- DOI
- 10.1164/rccm.202110-2265OC
- PMID
- 35104436
- PMCID
- PMC9851493
- ISSN
- 1073-449X
- eISSN
- 1535-4970
- Grant note
- U10 HL109086 / NHLBI NIH HHS U10 HL109146 / NHLBI NIH HHS U01 HL146002 / NHLBI NIH HHS U10 HL109257 / NHLBI NIH HHS U10 HL109168 / NHLBI NIH HHS U10 HL109164 / NHLBI NIH HHS P01 HL107202 / NHLBI NIH HHS R01 HL080414 / NHLBI NIH HHS U10 HL109152 / NHLBI NIH HHS U10 HL109172 / NHLBI NIH HHS
- Language
- English
- Date published
- 05/01/2022
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health and Human Physiology; Mechanical Engineering; Internal Medicine
- Record Identifier
- 9984274952902771
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