Journal article
Multi-Site Observational Study to Assess Biomarkers for Susceptibility or Resilience to Chronic Pain: The Acute to Chronic Pain Signatures (A2CPS) Study Protocol
Frontiers in medicine, Vol.9, 849214
04/01/2022
DOI: 10.3389/fmed.2022.849214
PMCID: PMC9082267
PMID: 35547202
Abstract
Chronic pain has become a global health problem contributing to years lived with disability and reduced quality of life. Advances in the clinical management of chronic pain have been limited due to incomplete understanding of the multiple risk factors and molecular mechanisms that contribute to the development of chronic pain. The Acute to Chronic Pain Signatures (A2CPS) Program aims to characterize the predictive nature of biomarkers (brain imaging, high-throughput molecular screening techniques, or “omics,” quantitative sensory testing, patient-reported outcome assessments and functional assessments) to identify individuals who will develop chronic pain following surgical intervention. The A2CPS is a multisite observational study investigating biomarkers and collective biosignatures (a combination of several individual biomarkers) that predict susceptibility or resilience to the development of chronic pain following knee arthroplasty and thoracic surgery. This manuscript provides an overview of data collection methods and procedures designed to standardize data collection across multiple clinical sites and institutions. Pain-related biomarkers are evaluated before surgery and up to 3 months after surgery for use as predictors of patient reported outcomes 6 months after surgery. The dataset from this prospective observational study will be available for researchers internal and external to the A2CPS Consortium to advance understanding of the transition from acute to chronic postsurgical pain.
Details
- Title: Subtitle
- Multi-Site Observational Study to Assess Biomarkers for Susceptibility or Resilience to Chronic Pain: The Acute to Chronic Pain Signatures (A2CPS) Study Protocol
- Creators
- Giovanni Berardi - University of IowaLaura Frey-Law - University of IowaKathleen A. Sluka - University of IowaEmine O. Bayman - University of IowaChristopher S. Coffey - University of IowaDixie Ecklund - University of IowaCarol G. T. Vance - University of IowaDana L. Dailey - Ambrose UniversityJohn Burns - Rush University Medical CenterAsokumar Buvanendran - Rush University Medical CenterRobert J. McCarthy - Rush University Medical CenterJoshua Jacobs - Rush University Medical CenterXiaohong Joe Zhou - University of Illinois ChicagoRichard Wixson - NorthShore University HealthSystemTessa Balach - University of ChicagoChad M. Brummett - University of MichiganDaniel Clauw - University of MichiganDouglas Colquhoun - University of MichiganSteven E. Harte - University of MichiganRichard E. Harris - University of MichiganDavid A. Williams - University of MichiganAndrew C. Chang - University of MichiganJennifer Waljee - University of MichiganKathleen M. Fisch - University of California San DiegoKristen Jepsen - University of California San DiegoLouise C. Laurent - University of California San DiegoMichael Olivier - 8Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United StatesCarl D. Langefeld - 9Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, United StatesTimothy D. Howard - 0Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, United StatesOliver Fiehn - University of California, DavisJon M. Jacobs - Pacific Northwest National LaboratoryPanshak Dakup - Pacific Northwest National LaboratoryWei-Jun Qian - Pacific Northwest National LaboratoryAdam C. Swensen - Pacific Northwest National LaboratoryAnna Lokshin - University of PittsburghMartin Lindquist - Johns Hopkins UniversityBrian S. Caffo - Johns Hopkins UniversityCiprian Crainiceanu - Johns Hopkins UniversityScott Zeger - Johns Hopkins UniversityAri Kahn - The University of Texas at AustinTor Wager - Dartmouth CollegeMargaret Taub - Johns Hopkins UniversityJames Ford - 7Geisel School of Medicine at Dartmouth, Hanover, NH, United StatesStephani P. Sutherland - Johns Hopkins UniversityLaura D. Wandner - National Institutes of Health
- Resource Type
- Journal article
- Publication Details
- Frontiers in medicine, Vol.9, 849214
- DOI
- 10.3389/fmed.2022.849214
- PMID
- 35547202
- PMCID
- PMC9082267
- NLM abbreviation
- Front Med (Lausanne)
- eISSN
- 2296-858X
- Publisher
- Frontiers Media S.A
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: U24NS112873-03S2, U54DA049115, U54DA049116, U54DA09113, UM1NS112874, UM1NS118922, UO1NS077179, UO1NS077352
- Language
- English
- Date published
- 04/01/2022
- Academic Unit
- Iowa Neuroscience Institute; Biostatistics; Nursing; Anesthesia; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology
- Record Identifier
- 9984251313202771
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