Journal article
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
Nature communications, Vol.11(1), pp.2542-2542
05/21/2020
DOI: 10.1038/s41467-020-15706-x
PMCID: PMC7242331
PMID: 32439900
Abstract
The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N = 293,051) genome-wide association meta-analysis for the PR interval, discovering 202 loci of which 141 have not previously been reported. Variants at identified loci increase the percentage of heritability explained, from 33.5% to 62.6%. We observe enrichment for cardiac muscle developmental/contractile and cytoskeletal genes, highlighting key regulation processes for atrioventricular conduction. Additionally, 8 loci not previously reported harbor genes underlying inherited arrhythmic syndromes and/or cardiomyopathies suggesting a role for these genes in cardiovascular pathology in the general population. We show that polygenic predisposition to PR interval duration is an endophenotype for cardiovascular disease, including distal conduction disease, AF, and atrioventricular pre-excitation. These findings advance our understanding of the polygenic basis of cardiac conduction, and the genetic relationship between PR interval duration and cardiovascular disease.
Details
- Title: Subtitle
- Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
- Creators
- Ioanna Ntalla - William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UKLu-Chen Weng - Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USAJames H Cartwright - William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UKAmelia Weber Hall - Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USAGardar Sveinbjornsson - deCODE genetics/Amgen, Inc., Reykjavik, IcelandNathan R Tucker - Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USASeung Hoan Choi - Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USAMark D Chaffin - Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USACarolina Roselli - Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The NetherlandsMichael R Barnes - National Institute for Health Research, Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UKBorbala Mifsud - College of Health and Life Sciences, Hamad Bin Khalifa University, Education City, Doha, QatarHelen R Warren - National Institute for Health Research, Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UKCaroline Hayward - Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UKJonathan Marten - Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UKJames J Cranley - William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UKMaria Pina Concas - Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, ItalyPaolo Gasparini - Department of Medicine, Surgery and Health Science, University of Trieste, Trieste, ItalyThibaud Boutin - Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UKIvana Kolcic - University of Split School of Medicine, Split, CroatiaOzren Polasek - Psychiatric Hospital Sveti Ivan, Zagreb, CroatiaIgor Rudan - Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UKNathalia M Araujo - Departamento de Biologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, BrazilMaria Fernanda Lima-Costa - Rene Rachou Reserch Institute, Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais, BrazilAntonio Luiz P Ribeiro - Hospital das Clínicas e Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, BrazilRenan P Souza - Departamento de Biologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, BrazilEduardo Tarazona-Santos - Departamento de Biologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, BrazilVilmantas Giedraitis - Department of Public Health, Geriatrics, Uppsala University, Uppsala, SwedenErik Ingelsson - Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, SwedenAnubha Mahajan - Wellcome Centre for Human Genetics, University of Oxford, Oxford, UKAndrew P Morris - Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UKFabiola Del Greco M - Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, ItalyLuisa Foco - Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, ItalyMartin Gögele - Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, ItalyAndrew A Hicks - Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, ItalyJames P Cook - Department of Biostatistics, University of Liverpool, Liverpool, UKLars Lind - Medical Sciences, Uppsala University Hospital, Uppsala, SwedenCecilia M Lindgren - The Broad Institute of MIT and Harvard, Cambridge, MA, USAJohan Sundström - Department of Medical Sciences, Uppsala University, Uppsala, SwedenChristopher P Nelson - NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Groby Road, Leicester, UKMuhammad B Riaz - NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Groby Road, Leicester, UKNilesh J Samani - NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Groby Road, Leicester, UKGianfranco Sinagra - Cardiovascular Department, Azienda Ospedaliera Universitaria Integrata of Trieste, Trieste, ItalySheila Ulivi - Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, ItalyMika Kähönen - Department of Clinical Physiology, Faculty of Medicine and Health Technology, Finnish Cardiovascular Research Center Tampere University, Tampere, FinlandPashupati P Mishra - Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Finnish Cardiovascular Research Center, Tampere University, Tampere, FinlandNina Mononen - Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Finnish Cardiovascular Research Center, Tampere University, Tampere, FinlandKjell Nikus - Department of Cardiology, Finnish Cardiovascular Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandMark J Caulfield - National Institute for Health Research, Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UKAnna Dominiczak - Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UKSandosh Padmanabhan - Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UKMay E Montasser - Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USAJeff R O'Connell - Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USAKathleen Ryan - Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USAAlan R Shuldiner - Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USAStefanie Aeschbacher - Cardiology Division, University Hospital, Basel, SwitzerlandDavid Conen - Population Health Research Institute, McMaster University, Hamilton, ON, CanadaLorenz Risch - Private University of the Principality of Liechtenstein, Triesen, LiechtensteinSébastien Thériault - Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University, Quebec, QC, CanadaNina Hutri-Kähönen - Department of Pediatrics, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandTerho Lehtimäki - Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Finnish Cardiovascular Research Center, Tampere University, Tampere, FinlandLeo-Pekka Lyytikäinen - Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, FinlandOlli T Raitakari - Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, FinlandCatriona L K Barnes - Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UKHarry Campbell - Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UKPeter K Joshi - Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UKJames F Wilson - Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UKAaron Isaacs - CARIM School for Cardiovascular Diseases, Maastricht Center for Systems Biology (MaCSBio), Department of Biochemistry, and Department of Physiology, Maastricht University, Maastricht, The NetherlandsJan A Kors - Department of Medical Informatics Erasmus MC, University Medical Center Rotterdam, Rotterdam, The NetherlandsCornelia M van Duijn - Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The NetherlandsPaul L Huang - Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USAVilmundur Gudnason - Faculty of Medicine, University of Iceland, Reykjavik, IcelandTamara B Harris - Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD, USALenore J Launer - Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD, USAAlbert V Smith - School of Public Health, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USAErwin P Bottinger - The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USARuth J F Loos - The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USAGirish N Nadkarni - The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USAMichael H Preuss - The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USAAdolfo Correa - Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USAHao Mei - Department of Data Science, University of Mississippi Medical Center, Jackson, MS, USAJames Wilson - Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USAThomas Meitinger - Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München, Munich, GermanyMartina Müller-Nurasyid - Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich, GermanyAnnette Peters - Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, GermanyMelanie Waldenberger - Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, GermanyMassimo Mangino - NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UKTimothy D Spector - Department of Twin Research and Genetic Epidemiology, Kings College London, London, UKMichiel Rienstra - Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The NetherlandsYordi J van de Vegte - Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The NetherlandsPim van der Harst - Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The NetherlandsNiek Verweij - Genomics plc, Oxford, UKStefan Kääb - Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich, GermanyKatharina Schramm - Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich, GermanyMoritz F Sinner - Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich, GermanyKonstantin Strauch - IBE, Faculty of Medicine, LMU Munich, Munich, GermanyMichael J Cutler - Intermountain Heart Institute, Intermountain Medical Center, Murray, UT, USADiane Fatkin - St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Kensington, NSW, AustraliaBarry London - Department of Cardiovascular Medicine, University of Iowa, Iowa City, IA, USAMorten Olesen - Department of Biomedical Sciences, University of Copenhagen, Copenhagen, DenmarkDan M Roden - Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USAM Benjamin Shoemaker - Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USAJ Gustav Smith - Department of Cardiology, Clinical Sciences, Wallenberg Center for Molecular Medicine, Lund University Diabetes Center, Lund University and Skane University Hospital, Lund, SwedenMary L Biggs - Department of Biostatistics, University of Washington, Seattle, WA, USAJoshua C Bis - Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USAJennifer A Brody - Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USABruce M Psaty - Kaiser Permanente Washington Health Research Institute, Seattle, WA, USAKenneth Rice - Department of Biostatistics, University of Washington, Seattle, WA, USANona Sotoodehnia - Cardiology Division, University of Washington, Seattle, WA, USAAlessandro De Grandi - Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, ItalyChristian Fuchsberger - Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, ItalyCristian Pattaro - Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, ItalyPeter P Pramstaller - Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, ItalyIan Ford - Robertson Center for Biostatistics, University of Glasgow, Glasgow, UKJ Wouter Jukema - Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The NetherlandsPeter W Macfarlane - Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UKStella Trompet - Department of Internal Medicine, section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The NetherlandsMarcus Dörr - Department of Internal Medicine B - Cardiology, Pneumology, Infectious Diseases, Intensive Care Medicine, University Medicine Greifswald, Greifswald, GermanyStephan B Felix - Department of Internal Medicine B - Cardiology, Pneumology, Infectious Diseases, Intensive Care Medicine, University Medicine Greifswald, Greifswald, GermanyUwe Völker - Interfaculty Institute for Genetics and Functional Genomics; Department of Functional Genomics; University Medicine and University of Greifswald, Greifswald, GermanyStefan Weiss - Interfaculty Institute for Genetics and Functional Genomics; Department of Functional Genomics; University Medicine and University of Greifswald, Greifswald, GermanyAki S Havulinna - Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, FinlandAntti Jula - Finnish Institute for Health and Welfare, Helsinki, FinlandKatri Sääksjärvi - Finnish Institute for Health and Welfare, Helsinki, FinlandVeikko Salomaa - Finnish Institute for Health and Welfare, Helsinki, FinlandXiuqing Guo - Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USASusan R Heckbert - Cardiovascular Health Research Unit and Department of Epidemiology, University of Washington, Seattle, WA, USAHenry J Lin - Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USAJerome I Rotter - Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USAKent D Taylor - Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USAJie Yao - Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USARenée de Mutsert - Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The NetherlandsArie C Maan - Department of Cardiology, Leiden University Medical Center, Leiden, The NetherlandsDennis O Mook-Kanamori - Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The NetherlandsRaymond Noordam - Department of Internal Medicine, section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The NetherlandsFrancesco Cucca - Department of Biomedical Sciences, University of Sassari, Sassari, ItalyJun Ding - Laboratory of Genetics and Genomics, NIA/NIH, Baltimore, MD, USAEdward G Lakatta - Laboratory of Cardiovascular Science, NIA/NIH, Baltimore, MD, USAYong Qian - Laboratory of Genetics and Genomics, NIA/NIH, Baltimore, MD, USAKirill V Tarasov - Laboratory of Cardiovascular Science, NIA/NIH, Baltimore, MD, USADaniel Levy - National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USAHonghuang Lin - Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USAChristopher H Newton-Cheh - Center for Human Genetic Research and Cardiovascular Research Center, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USAKathryn L Lunetta - Department of Biostatistics, Boston University School of Public Health, Boston, MA, USAAlison D Murray - The Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, UKDavid J Porteous - Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UKBlair H Smith - Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UKBruno H Stricker - Department of Epidemiology Erasmus MC, University Medical Center Rotterdam, Rotterdam, The NetherlandsAndré Uitterlinden - Human Genotyping Facility Erasmus MC University Medical Center Rotterdam, Rotterdam, The NetherlandsMarten E van den Berg - Department of Epidemiology Erasmus MC, University Medical Center Rotterdam, Rotterdam, The NetherlandsJeffrey Haessler - Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USARebecca D Jackson - Division of Endocrinology, Diabetes and Metabolism, Ohio State University, Columbus, OH, USACharles Kooperberg - Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USAUlrike Peters - Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USAAlexander P Reiner - Department of Epidemiology, University of Washington, Seattle, WA, USAEric A Whitsel - Departments of Epidemiology and Medicine, Gillings School of Global Public Health and School of Medicine, University of North Carolina, Chapel Hill, NC, USAAlvaro Alonso - Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USADan E Arking - McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USAEric Boerwinkle - Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USAGeorg B Ehret - Cardiology, Geneva University Hospitals, Geneva, SwitzerlandElsayed Z Soliman - Epidemiological Cardiology Research Center, Wake Forest School of Medicine, Winston-Salem, NC, USAChristy L Avery - Carolina Population Center, University of North Carolina, Chapel Hill, NC, USAStephanie M Gogarten - Department of Biostatistics, University of Washington, Seattle, WA, USAKathleen F Kerr - Department of Biostatistics, University of Washington, Seattle, WA, USACathy C Laurie - Department of Biostatistics, University of Washington, Seattle, WA, USAAmanda A Seyerle - Division of Pharmaceutical Outcomes and Policy, University of North Carolina, Chapel Hill, NC, USAAdrienne Stilp - Department of Biostatistics, University of Washington, Seattle, WA, USASolmaz Assa - Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The NetherlandsM Abdullah Said - Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The NetherlandsM Yldau van der Ende - Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The NetherlandsPier D Lambiase - Institute of Cardiovascular Science, University College London, London, UKMichele Orini - Department of Mechanical Engineering, University College London, London, UKJulia Ramirez - Institute of Cardiovascular Science, University College London, London, UKStefan Van Duijvenboden - Institute of Cardiovascular Science, University College London, London, UKDavid O Arnar - Department of Medicine, Landspitali University Hospital, Reykjavik, IcelandDaniel F Gudbjartsson - School of Engineering and Natural Sciences, University of Iceland, Reykjavik, IcelandHilma Holm - deCODE genetics/Amgen, Inc., Reykjavik, IcelandPatrick Sulem - deCODE genetics/Amgen, Inc., Reykjavik, IcelandGudmar Thorleifsson - deCODE genetics/Amgen, Inc., Reykjavik, IcelandRosa B Thorolfsdottir - Faculty of Medicine, University of Iceland, Reykjavik, IcelandUnnur Thorsteinsdottir - Faculty of Medicine, University of Iceland, Reykjavik, IcelandEmelia J Benjamin - Department of Epidemiology, Boston University School of Public Health, Boston, MA, USAAndrew Tinker - National Institute for Health Research, Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UKKari Stefansson - Faculty of Medicine, University of Iceland, Reykjavik, IcelandPatrick T Ellinor - Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, MA, USAYalda Jamshidi - Genetics Research Centre, Molecular and Clinical Sciences Institute, St George's, University of London, London, UKSteven A Lubitz - Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, MA, USA. slubitz@mgh.harvard.eduPatricia B Munroe - National Institute for Health Research, Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK. p.b.munroe@qmul.ac.uk
- Resource Type
- Journal article
- Publication Details
- Nature communications, Vol.11(1), pp.2542-2542
- DOI
- 10.1038/s41467-020-15706-x
- PMID
- 32439900
- PMCID
- PMC7242331
- NLM abbreviation
- Nat Commun
- ISSN
- 2041-1723
- eISSN
- 2041-1723
- Publisher
- England
- Grant note
- U01 HL130114 / NHLBI NIH HHS MC_UU_00007/10 / Medical Research Council PG/17/59/33139 / British Heart Foundation R01 HL139731 / NHLBI NIH HHS MR/N025083/1 / Medical Research Council R01 HL105756 / NHLBI NIH HHS K24 HL148521 / NHLBI NIH HHS G9521010 / Medical Research Council
- Language
- English
- Date published
- 05/21/2020
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984066335202771
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