Journal article
Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids
Nature genetics, Vol.51(4), pp.636-648
04/2019
DOI: 10.1038/s41588-019-0378-y
PMCID: PMC6467258
PMID: 30926973
Abstract
The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.
Details
- Title: Subtitle
- Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids
- Creators
- Amy R Bentley - Center for Research on Genomics and Global Health, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA. amy.bentley@nih.govYun J Sung - Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USAMichael R Brown - Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USAThomas W Winkler - Department of Genetic Epidemiology, University of Regensburg, Regensburg, GermanyAldi T Kraja - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USAIoanna Ntalla - Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UKKaren Schwander - Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USADaniel I Chasman - Harvard Medical School, Boston, MA, USAElise Lim - Department of Biostatistics, Boston University School of Public Health, Boston, MA, USAXuan Deng - Boston UniversityXiuqing Guo - Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USAJingmin Liu - Women's Health Initiative Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USAYingchang Lu - Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USAChing-Yu Cheng - Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeXueling Sim - Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, SingaporeDina Vojinovic - Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the NetherlandsJennifer E Huffman - Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UKSolomon K Musani - Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USAChangwei Li - Epidemiology and Biostatistics, University of Georgia at Athens College of Public Health, Athens, GA, USAMary F Feitosa - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USAMelissa A Richard - Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USARaymond Noordam - Internal Medicine, Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the NetherlandsJenna Baker - Center for Research on Genomics and Global Health, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USAGuanjie Chen - Center for Research on Genomics and Global Health, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USAHugues Aschard - Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USATraci M Bartz - Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USAJingzhong Ding - Center on Diabetes, Obesity, and Metabolism, Gerontology and Geriatric Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, USARajkumar Dorajoo - Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, SingaporeAlisa K Manning - Department of Medicine, Harvard Medical School, Boston, MA, USATuomo Rankinen - Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USAAlbert V Smith - Faculty of Medicine, University of Iceland, Reykjavik, IcelandSalman M Tajuddin - Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, US National Institutes of Health, Baltimore, MD, USAWei Zhao - University of MichiganMariaelisa Graff - Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAMaris Alver - Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, EstoniaMathilde Boissel - CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, FranceJin Fang Chai - Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, SingaporeXu Chen - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenJasmin Divers - Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USAEvangelos Evangelou - Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, GreeceChuan Gao - Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston-Salem, NC, USAAnuj Goel - Wellcome Centre for Human Genetics, University of Oxford, Oxford, UKYanick Hagemeijer - University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the NetherlandsSarah E Harris - Medical Genetics Section, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UKFernando P Hartwig - Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UKMeian He - Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaAndrea R V R Horimoto - Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, BrazilFang-Chi Hsu - Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USAYi-Jen Hung - School of Medicine, National Defense Medical Center, Taipei, TaiwanAnne U Jackson - Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USAAnuradhani Kasturiratne - Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri LankaPirjo Komulainen - Foundation for Research in Health, Exercise, and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, FinlandBrigitte Kühnel - Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, GermanyKarin Leander - Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SwedenKeng-Hung Lin - Ophthalmology, Taichung Veterans General Hospital, Taichung, TaiwanJian'an Luan - Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UKLeo-Pekka Lyytikäinen - Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Technology, Tampere University, Tampere, FinlandNana Matoba - Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, JapanIlja M Nolte - University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, the NetherlandsMaik Pietzner - Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, GermanyBram Prins - Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UKMuhammad Riaz - NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UKAntonietta Robino - Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, ItalyM Abdullah Said - University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the NetherlandsNicole Schupf - Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USATamar Sofer - Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USAAlena Stancáková - Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, FinlandFumihiko Takeuchi - Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, JapanBamidele O Tayo - Department of Public Health Sciences, Loyola University Chicago, Maywood, IL, USAPeter J van der Most - University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, the NetherlandsTibor V Varga - Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, SwedenTzung-Dau Wang - Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, TaiwanErin B Ware - Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USAWanqing Wen - Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USAYong-Bing Xiang - SKLORG and Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaLisa R Yanek - Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USAJing Hua Zhao - Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UKAdebowale Adeyemo - Center for Research on Genomics and Global Health, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USASaima Afaq - MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College, London, UKNajaf Amin - Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the NetherlandsMarzyeh Amini - University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, the NetherlandsDan E Arking - McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USAZorayr Arzumanyan - Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USATin Aung - Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, SingaporeChristie Ballantyne - Houston Methodist Debakey Heart and Vascular Center, Houston, TX, USAR Graham Barr - Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY, USALawrence F Bielak - Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USAEric Boerwinkle - Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USAErwin P Bottinger - Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USAUlrich Broeckel - Section of Genomic Pediatrics, Departments of Pediatrics, Medicine, and Physiology, Medical College of Wisconsin, Milwaukee, WI, USAMorris Brown - NIHR Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UKBrian E Cade - Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USAMickaël Canouil - CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, FranceSabanayagam Charumathi - Centre for Quantitative Medicine, Academic Medicine Research Institute, Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, SingaporeYii-Der Ida Chen - Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USAKaare Christensen - Danish Aging Research Center, Institute of Public Health, University of Southern Denmark, Odense, DenmarkMaria Pina Concas - Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, ItalyJohn M Connell - Ninewells Hospital and Medical School, University of Dundee, Dundee, UKLisa de Las Fuentes - Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USAH Janaka de Silva - Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri LankaPaul S de Vries - Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USAAyo Doumatey - Center for Research on Genomics and Global Health, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USAQing Duan - Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USACharles B Eaton - Department of Family Medicine and Epidemiology, Alpert Medical School of Brown University, Providence, RI, USARuben N Eppinga - University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the NetherlandsJessica D Faul - Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USAJames S Floyd - Department of Epidemiology, University of Washington, Seattle, WA, USANita G Forouhi - Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UKTerrence Forrester - UWI Solutions for Developing Countries, University of the West Indies, Kingston, JamaicaYechiel Friedlander - Braun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem, IsraelIlaria Gandin - Department of Medical Sciences, University of Trieste, Trieste, ItalyHe Gao - Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UKMohsen Ghanbari - Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranSina A Gharib - Computational Medicine Core, Center for Lung Biology, UW Medicine Sleep Center, Department of Medicine, University of Washington, Seattle, WA, USABruna Gigante - Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SwedenFranco Giulianini - Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USAHans J Grabe - Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, GermanyChew-Kiat Heng - Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, SingaporeC Charles Gu - Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USAMakoto Hirata - Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, University of Tokyo, Minato-ku, JapanTamara B Harris - Laboratory of Epidemiology and Population Sciences, National Institute on Aging, US National Institutes of Health, Bethesda, MD, USAJames E Hixson - Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USASami Heikkinen - Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, FinlandM Arfan Ikram - Department of Neurology, Erasmus University Medical Center, Rotterdam, the NetherlandsRoby Joehanes - Framingham Heart Study, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, MD, USACraig Johnson - Collaborative Health Studies Coordinating Center, University of Washington, Seattle, WA, USAJost Bruno Jonas - Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing Tongren Eye Center, Capital Medical University, Beijing, ChinaAnne E Justice - Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USATomohiro Katsuya - Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, JapanChiea Chuen Khor - Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, SingaporeTuomas O Kilpeläinen - Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USAWoon-Puay Koh - Duke-NUS Medical School, Singapore, SingaporeIvana Kolcic - Department of Public Health, Department of Medicine, University of Split, Split, CroatiaCharles Kooperberg - Fred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, WA, USAJose E Krieger - Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, BrazilStephen B Kritchevsky - Sticht Center for Healthy Aging and Alzheimer's Prevention, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USAMichiaki Kubo - RIKEN Center for Integrative Medical Sciences, Yokohama, JapanJohanna Kuusisto - Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, FinlandTimo A Lakka - Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, FinlandLenore J Launer - Laboratory of Epidemiology and Population Sciences, National Institute on Aging, US National Institutes of Health, Bethesda, MD, USAClaudia Langenberg - Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UKBenjamin Lehne - Institute of Clinical Sciences, Department of Molecular Sciences, Imperial College, London, UKCora E Lewis - Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USACarl D Langefeld - Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USAJingjing Liang - Department of Population Quantitative and Health Sciences, Case Western Reserve University, Cleveland, OH, USAChing-Ti Liu - Department of Biostatistics, Boston University School of Public Health, Boston, MA, USAJianjun Liu - Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeMarie Loh - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, SingaporeKurt K Lohman - Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USATin Louie - Department of Biostatistics, University of Washington, Seattle, WA, USAAnna Luzzi - Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USAReedik Mägi - Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, EstoniaAnubha Mahajan - Wellcome Centre for Human Genetics, University of Oxford, Oxford, UKAni W Manichaikul - Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USAColin A McKenzie - Tropical Metabolism Research Unit, Caribbean Institute for Health Research, University of the West Indies, Mona, JamaicaThomas Meitinger - Technische Universität München, Munich, GermanyAndres Metspalu - Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, EstoniaYuri Milaneschi - Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam, the NetherlandsLili Milani - Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, EstoniaKaren L Mohlke - Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAYukihide Momozawa - Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, JapanAndrew P Morris - Department of Biostatistics, University of Liverpool, Liverpool, UKAlison D Murray - Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, UKMike A Nalls - Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USAMatthias Nauck - Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, GermanyChristopher P Nelson - NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UKKari E North - Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAJeffrey R O'Connell - Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USANicholette D Palmer - Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USAGeorge J Papanicolau - Epidemiology Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, MD, USANancy L Pedersen - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenAnnette Peters - Epidemiology, Faculty of Medicine, Institute for Medical Information Processing, Biometry, and Epidemiology, Ludwig Maximilian University, Munich, GermanyPatricia A Peyser - Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USAJennifer G Robinson - Department of Epidemiology and Medicine, University of Iowa, Iowa City, IA, USAOzren Polasek - Gen-info, Ltd, Zagreb, CroatiaLynda M Rose - Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USANeil Poulter - School of Public Health, Imperial College, London, UKFrits R Rosendaal - Clinical Epidemiology, Leiden University Medical Center, Leiden, the NetherlandsOlli T Raitakari - Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, FinlandIgor Rudan - Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UKAlex P Reiner - Fred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, WA, USACarsten O Schmidt - Institute for Community Medicine, University Medicine Greifswald, Greifswald, GermanyFrida Renström - Department of Biobank Research, Umeå University, Umeå, SwedenPamela J Schreiner - Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USATreva K Rice - Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USAStephen S Rich - Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USAPeter Sever - National Heart and Lung Institute, Imperial College, London, UKYuan Shi - Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, SingaporeStephen Sidney - Division of Research, Kaiser Permanente Northern California, Oakland, CA, USAMario Sims - Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USAJennifer A Smith - Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USAHarold Snieder - University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, the NetherlandsKonstantin Strauch - Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, GermanyJohn M Starr - Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UKNicholas Y Q Tan - Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, SingaporeHua Tang - Department of Genetics, Stanford University, Stanford, CA, USAKent D Taylor - Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USAYik Ying Teo - NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore, SingaporeHenning Tiemeier - Department of Social and Behavioral Sciences, Harvard T. H. Chan School of Public Health, Boston, MA, USAStephen T Turner - Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USAAndré G Uitterlinden - Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the NetherlandsDiana van Heemst - Internal Medicine, Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the NetherlandsMelanie Waldenberger - Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, GermanyHeming Wang - Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USALan Wang - Department of Biostatistics, Boston University School of Public Health, Boston, MA, USAYih Chung Tham - Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, SingaporeLihua Wang - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USAWen Bin Wei - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, ChinaChristine A Williams - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USAGregory Wilson Sr - Jackson Heart Study, School of Public Health, Jackson State University, Jackson, MS, USAMary K Wojczynski - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USAJie Yao - Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USAKristin Young - Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAJian-Min Yuan - Division of Cancer Control and Population Sciences, UPMC Hillman Cancer, University of Pittsburgh, Pittsburgh, PA, USAJie Zhou - Center for Research on Genomics and Global Health, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USAAlan B Zonderman - Behavioral Epidemiology Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, US National Institutes of Health, Baltimore, MD, USADiane M Becker - Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USAMichael Boehnke - Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USADonald W Bowden - Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USAJohn C Chambers - Imperial College Healthcare NHS Trust, London, UKRichard S Cooper - Department of Public Health Sciences, Loyola University Chicago, Maywood, IL, USAUlf de Faire - Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SwedenIan J Deary - Psychology, University of Edinburgh, Edinburgh, UKPaul Elliott - MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College, London, UKTõnu Esko - Broad Institute of MIT and Harvard, Boston, MA, USAMartin Farrall - Wellcome Centre for Human Genetics, University of Oxford, Oxford, UKPaul W Franks - OCDEM, Radcliffe Department of Medicine, University of Oxford, Oxford, UKBarry I Freedman - Nephrology, Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USAPhilippe Froguel - Department of Genomics of Common Disease, Imperial College, London, UKYoichiro Kamatani - Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, JapanJyh-Ming Jimmy Juang - Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, TaiwanPaolo Gasparini - Department of Medical Sciences, University of Trieste, Trieste, ItalyTerho Lehtimäki - Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Technology, Tampere University, Tampere, FinlandChristian Gieger - German Center for Diabetes Research (DZD), Neuherberg, GermanyBernardo L Horta - Postgraduate Programme in Epidemiology, Federal University of Pelotas, Pelotas, BrazilCandace M Kammerer - Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USAPatrik K E Magnusson - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenNorihiro Kato - Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, JapanAlbertine J Oldehinkel - University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, the NetherlandsBrenda W J H Penninx - Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam, the NetherlandsJaspal S Kooner - Imperial College Healthcare NHS Trust, London, UKRainer Rauramaa - Foundation for Research in Health, Exercise, and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, FinlandMarkku Laakso - Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, FinlandSusan Redline - Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USACathy C Laurie - Department of Biostatistics, University of Washington, Seattle, WA, USANilesh J Samani - NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UKJames Scott - National Heart and Lung Institute, Imperial College, London, UKXiao-Ou Shu - Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USAPim van der Harst - University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, the NetherlandsLynne E Wagenknecht - Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USAYa Xing Wang - Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing Tongren Eye Center, Capital Medical University, Beijing, ChinaNicholas J Wareham - Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UKHugh Watkins - Wellcome Centre for Human Genetics, University of Oxford, Oxford, UKDavid R Weir - Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USAAnanda R Wickremasinghe - Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri LankaTangchun Wu - Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaEleftheria Zeggini - Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, GermanyWei Zheng - Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USAClaude Bouchard - Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USAMichele K Evans - Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, US National Institutes of Health, Baltimore, MD, USAVilmundur Gudnason - Faculty of Medicine, University of Iceland, Reykjavik, IcelandSharon L R Kardia - Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USAYongmei Liu - Public Health Sciences, Epidemiology and Prevention, Wake Forest University Health Sciences, Winston-Salem, NC, USABruce M Psaty - Kaiser Permanente Washington Health Research Institute, Seattle, WA, USAPaul M Ridker - Harvard Medical School, Boston, MA, USARob M van Dam - Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeCaroline Hayward - Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UKDennis O Mook-Kanamori - Public Health and Primary Care, Leiden University Medical Center, Leiden, the NetherlandsMyriam Fornage - Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USACornelia M van Duijn - Nuffield Department of Population Health, University of Oxford, Oxford, UKMichael A Province - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USAE Shyong Tai - Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeTanika N Kelly - Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USATien Yin Wong - Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, SingaporeRuth J F Loos - Mindich Child Health Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USAErvin R Fox - Cardiology, Medicine, University of Mississippi Medical Center, Jackson, MS, USANora Franceschini - Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAJerome I Rotter - Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USALaura J Bierut - Psychiatry, Washington University School of Medicine, St. Louis, MO, USAW James Gauderman - Biostatistics, Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USAKenneth Rice - Department of Biostatistics, University of Washington, Seattle, WA, USAPatricia B Munroe - NIHR Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UKAlanna C Morrison - Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USADabeeru C Rao - Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USACharles N Rotimi - Center for Research on Genomics and Global Health, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA. rotimic@mail.nih.govL Adrienne Cupples - Framingham Heart Study, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, MD, USA. adrienne@bu.eduCOGENT-Kidney ConsortiumYajuan Wang - Case Western Reserve UniversityArchie Campbell - University of EdinburghRobert A Scott - University of CambridgeJun-Sing Wang - National Yang Ming UniversityI-Te Lee - National Yang Ming UniversityWilliam R Scott - Imperial College LondonKiang Liu - Northwestern UniversityYize Li - Washington University in St. LouisShiow Lin - Washington University in St. LouisXiaofeng Zhu - Case Western Reserve UniversityYucheng Jia - University of California, Los AngelesHeather M Stringham - University of MichiganWeihua Zhang - Ealing HospitalAlexandre C Pereira - Universidade de São PauloCaizheng Yu - Huazhong University of Science and Technology
- Resource Type
- Journal article
- Publication Details
- Nature genetics, Vol.51(4), pp.636-648
- DOI
- 10.1038/s41588-019-0378-y
- PMID
- 30926973
- PMCID
- PMC6467258
- NLM abbreviation
- Nat Genet
- ISSN
- 1061-4036
- eISSN
- 1546-1718
- Publisher
- United States
- Grant note
- K01 HL135405 / NHLBI NIH HHS R01 DK062370 / NIDDK NIH HHS MR/L01632X/1 / Medical Research Council R21 HL123677 / NHLBI NIH HHS R01 DK072193 / NIDDK NIH HHS R01 DK107786 / NIDDK NIH HHS Z99 HG999999 / Intramural NIH HHS MR/R023484/1 / Medical Research Council MR/L01341X/1 / Medical Research Council R01 HL142302 / NHLBI NIH HHS MR/K002414/1 / Medical Research Council ZIA HG200362-02 / Intramural NIH HHS MC_UP_1605/7 / Medical Research Council P30 ES007048 / NIEHS NIH HHS P2C HD050924 / NICHD NIH HHS U01 AG009740 / NIA NIH HHS MC_UU_00007/10 / Medical Research Council MC_UU_12015/1 / Medical Research Council R01 DK093757 / NIDDK NIH HHS Z01 HG200362 / Intramural NIH HHS R01 DK117445 / NIDDK NIH HHS R01 HL105756 / NHLBI NIH HHS R01 HL118305 / NHLBI NIH HHS U01 DK062370 / NIDDK NIH HHS P30 DK020572 / NIDDK NIH HHS BB/F019394/1 / Biotechnology and Biological Sciences Research Council R01 HD057194 / NICHD NIH HHS R01 MD012765 / NIMHD NIH HHS
- Language
- English
- Date published
- 04/2019
- Academic Unit
- Epidemiology; Internal Medicine
- Record Identifier
- 9983995166602771
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