Journal article
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
Nature communications, Vol.10(1), pp.376-376
01/22/2019
DOI: 10.1038/s41467-018-08008-w
PMCID: PMC6342931
PMID: 30670697
Abstract
Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels.
Details
- Title: Subtitle
- Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
- Creators
- Tuomas O Kilpeläinen - Department of Environmental Medicine and Public Health, The Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA. tuomas.kilpelainen@sund.ku.dkAmy R Bentley - Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, 20892, MD, USARaymond Noordam - Internal Medicine, Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2300 RC, The NetherlandsYun Ju Sung - Division of Biostatistics, Washington University School of Medicine, St. Louis, 63110, MO, USAKaren Schwander - Division of Biostatistics, Washington University School of Medicine, St. Louis, 63110, MO, USAThomas W Winkler - Department of Genetic Epidemiology, University of Regensburg, Regensburg, 93051, GermanyHermina Jakupović - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, DenmarkDaniel I Chasman - Harvard Medical School, Boston, 02131, MA, USAAlisa Manning - Department of Medicine, Harvard Medical School, Boston, 02115, MA, USAIoanna Ntalla - Clinical Pharmacology, William Harvey Research Instititute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UKHugues Aschard - Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Institut Pasteur, Paris, 75015, FranceMichael R Brown - Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, 77030, TX, USALisa de Las Fuentes - Cardiovascular Division, Department of Medicine, Washington University, St. Louis, 63110, MO, USANora Franceschini - Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, 27514, NC, USAXiuqing Guo - The Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, 90502, CA, USADina Vojinovic - Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CE, The NetherlandsStella Aslibekyan - Department of Epidemiology, University of Alabama at Birmingham, Birmingham, 35294, AL, USAMary F Feitosa - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, 63108, MO, USAMinjung Kho - Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, 48109, MI, USASolomon K Musani - Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, 39213, MS, USAMelissa Richard - Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, 77030, TX, USAHeming Wang - Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, 02115, MA, USAZhe Wang - The University of Texas Health Science Center at HoustonTraci M Bartz - Cardiovascular Health Research Unit, Biostatistics and Medicine, University of Washington, Seattle, 98101, WA, USALawrence F Bielak - Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, 48109, MI, USAArchie Campbell - Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UKRajkumar Dorajoo - Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, 138672, SingaporeVirginia Fisher - Biostatistics, Boston University School of Public Health, Boston, 02118, MA, USAFernando P Hartwig - Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UKAndrea R V R Horimoto - Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, 01246903, SP, BrazilChangwei Li - Epidemiology and Biostatistics, University of Giorgia at Athens College of Public Health, Athens, 30602, GA, USAKurt K Lohman - Public Health Sciences, Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, 27157, NC, USAJonathan Marten - Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UKXueling Sim - Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, 117549, SingaporeAlbert V Smith - Department of Biostatistics, University of Michigan, Ann Arbor, 48109, MI, USASalman M Tajuddin - Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, 21224, MD, USAMaris Alver - Estonian Genome Center, University of Tartu, Tartu, 51010, EstoniaMarzyeh Amini - Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The NetherlandsMathilde Boissel - CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, 59000, FranceJin Fang Chai - Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, 117549, SingaporeXu Chen - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, 17177, SwedenJasmin Divers - Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, 27157, NC, USAEvangelos Evangelou - Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, 45110, GreeceChuan Gao - Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston-Salem, 27157, NC, USAMariaelisa Graff - Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, 27514, NC, USASarah E Harris - Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, EH8 9JZ, UKMeian He - Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, ChinaFang-Chi Hsu - Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, 27157, NC, USAAnne U Jackson - Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, 48109, MI, USAJing Hua Zhao - MRC Epidemiology Unit, University of Cambridge, Cambridge, CB2 0QQ, UKAldi T Kraja - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, 63108, MO, USABrigitte Kühnel - Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764, GermanyFederica Laguzzi - Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, 17177, SwedenLeo-Pekka Lyytikäinen - Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, 33014, FinlandIlja M Nolte - Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The NetherlandsRainer Rauramaa - Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, FinlandMuhammad Riaz - College of Medicine, Biological Sciences and Psychology, Health Sciences, The Infant Mortality and Morbidity Studies (TIMMS), Leicester, LE1 7RH, UKAntonietta Robino - Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Trieste, 34137, ItalyRico Rueedi - Swiss Institute of Bioinformatics, 1015, Lausanne, SwitzerlandHeather M Stringham - Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, 48109, MI, USAFumihiko Takeuchi - Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, 1628655, JapanPeter J van der Most - Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The NetherlandsTibor V Varga - Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, 20502, SwedenNiek Verweij - University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, 9700 RB, The NetherlandsErin B Ware - Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, 48104, MI, USAWanqing Wen - Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, 37203, TN, USAXiaoyin Li - Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, 44106, OH, USALisa R Yanek - Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, 21287, MD, USANajaf Amin - Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CE, The NetherlandsDonna K Arnett - Dean's Office, University of Kentucky College of Public Health, Lexington, 40536, KY, USAEric Boerwinkle - Human Genome Sequencing Center, Baylor College of Medicine, Houston, 77030, TX, USAMarco Brumat - Department of Medical Sciences, University of Trieste, Trieste, 34137, ItalyBrian Cade - Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, 02115, MA, USAMickaël Canouil - CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, 59000, FranceYii-Der Ida Chen - The Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, 90502, CA, USAMaria Pina Concas - Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Trieste, 34137, ItalyJohn Connell - Ninewells Hospital & Medical School, University of Dundee, Dundee, DD1 9SY, Scotland, UKRenée de Mutsert - Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, NetherlandsH Janaka de Silva - Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, 11600, Sri LankaPaul S de Vries - Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, 77030, TX, USAAyşe Demirkan - Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CE, The NetherlandsJingzhong Ding - Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, 27157, NC, USACharles B Eaton - Department of Family Medicine and Epidemiology, Alpert Medical School of Brown University, Providence, 02860, RI, USAJessica D Faul - Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, 48104, MI, USAYechiel Friedlander - Braun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem, 91120, IsraelKelley P Gabriel - Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Austin, Austin, 78712, TX, USAMohsen Ghanbari - Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, 91778-99191, IranFranco Giulianini - Preventive Medicine, Brigham and Women's Hospital, Boston, 02215, MA, USAChi Charles Gu - Division of Biostatistics, Washington University School of Medicine, St. Louis, 63110, MO, USADongfeng Gu - Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100006, ChinaTamara B Harris - Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, 20892, MD, USAJiang He - Medicine, Tulane University School of Medicine, New Orleans, 70112, LA, USASami Heikkinen - Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, 70210, FinlandChew-Kiat Heng - Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, 119228, SingaporeSteven C Hunt - Department of Genetic Medicine, Weill Cornell Medicine, Doha, 24144, QatarM Arfan Ikram - Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, 3015 GD, The NetherlandsJost B Jonas - Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, ChinaWoon-Puay Koh - Health Services and Systems Research, Duke-NUS Medical School, Singapore, 169857, SingaporePirjo Komulainen - Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, FinlandJose E Krieger - Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, 01246903, SP, BrazilStephen B Kritchevsky - Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, 27157, NC, USAZoltán Kutalik - Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, 1010, SwitzerlandJohanna Kuusisto - Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, 70210, FinlandCarl D Langefeld - Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, 27157, NC, USAClaudia Langenberg - MRC Epidemiology Unit, University of Cambridge, Cambridge, CB2 0QQ, UKLenore J Launer - Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, 20892, MD, USAKarin Leander - Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, 17177, SwedenRozenn N Lemaitre - Cardiovascular Health Research Unit, Medicine, University of Washington, Seattle, 98101, WA, USACora E Lewis - Division of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham, School of Medicine, Birmingham, 35294, AL, USAJingjing Liang - Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, 44106, OH, USAJianjun Liu - Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, SingaporeReedik Mägi - Estonian Genome Center, University of Tartu, Tartu, 51010, EstoniaAni Manichaikul - Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, 22908, VA, USAThomas Meitinger - Institute of Human Genetics, Technische Universität München, Munich, 80333, GermanyAndres Metspalu - Estonian Genome Center, University of Tartu, Tartu, 51010, EstoniaYuri Milaneschi - Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, 1081 HV, The NetherlandsKaren L Mohlke - Department of Genetics, University of North Carolina, Chapel Hill, 27514, NC, USAThomas H Mosley Jr - Geriatrics, Medicine, University of Mississippi, Jackson, 39216, MS, USAMike A Nalls - Data Tecnica International, Glen Echo, 20812, MD, USAEi-Ei Khaing Nang - Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, 117549, SingaporeChristopher P Nelson - NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, LE3 9QD, UKSotoodehnia Nona - Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, 98101, WA, USAJill M Norris - Department of Epidemiology, University of Colorado Denver, Aurora, 80045, CO, USAChiamaka Vivian Nwuba - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, DenmarkJeff O'Connell - Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, 21201, MD, USANicholette D Palmer - Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, 27157, NC, USAGeorge J Papanicolau - Epidemiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, 20892, MD, USARaha Pazoki - Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UKNancy L Pedersen - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, 17177, SwedenAnnette Peters - DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Neuherberg, 85764, GermanyPatricia A Peyser - Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, 48109, MI, USAOzren Polasek - Gen-Info Ltd., 10000, Zagreb, CroatiaDavid J Porteous - Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, EH8 9JZ, UKAlaitz Poveda - Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, 20502, SwedenOlli T Raitakari - Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, 20520, FinlandStephen S Rich - Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, 22908, VA, USANeil Risch - Institute for Human Genetics, Department of Epidemiology and Biostatistics, University of California, San Francisco, 94143, CA, USAJennifer G Robinson - Department of Epidemiology and Medicine, University of Iowa, Iowa City, 52242, IA, USALynda M Rose - Preventive Medicine, Brigham and Women's Hospital, Boston, 02215, MA, USAIgor Rudan - Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH16 4UX, UKPamela J Schreiner - Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, 55454, MN, USARobert A Scott - MRC Epidemiology Unit, University of Cambridge, Cambridge, CB2 0QQ, UKStephen S Sidney - Kaiser Permanente Washington, Health Research Institute, Seattle, 98101, WA, USAMario Sims - Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, 39213, MS, USAJennifer A Smith - Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, 48104, MI, USAHarold Snieder - Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The NetherlandsTamar Sofer - Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, 02115, MA, USAJohn M Starr - Alzheimer Scotland Dementia Research Centre, The University of Edinburgh, Edinburgh, EH8 9JZ, UKBarbara Sternfeld - Kaiser Permanente Washington, Health Research Institute, Seattle, 98101, WA, USAKonstantin Strauch - Institute of Medical Informatics Biometry and Epidemiology, Ludwig-Maximilians-Universitat Munchen, Munich, 81377, GermanyHua Tang - Department of Genetics, Stanford University, Stanford, 94305, CA, USAKent D Taylor - The Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, 90502, CA, USAMichael Y Tsai - Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, 55455, MN, USAJaakko Tuomilehto - Diabetes Research Group, King Abdulaziz University, Jeddah, 21589, Saudi ArabiaAndré G Uitterlinden - Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, 3015 CE, The NetherlandsM Yldau van der Ende - University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, 9700 RB, The NetherlandsDiana van Heemst - Internal Medicine, Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2300 RC, The NetherlandsTrudy Voortman - Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CE, The NetherlandsMelanie Waldenberger - Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764, GermanyPatrik Wennberg - Department of Public Health & Clinical Medicine, Umeå University, Umeå, 90185, Västerbotten, SwedenGregory Wilson - Jackson Heart Study, School of Public Health, Jackson State University, Jackson, 39213, MS, USAYong-Bing Xiang - State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200000, ChinaJie Yao - The Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, 90502, CA, USAJian-Min Yuan - Division of Cancer Control and Population Sciences, UPMC Hillman Cancer, University of Pittsburgh, Pittsburgh, 15232, PA, USAWei Zhao - Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, 48109, MI, USAAlan B Zonderman - Behavioral Epidemiology Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, 21224, MD, USADiane M Becker - Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, 21287, MD, USAMichael Boehnke - Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, 48109, MI, USADonald W Bowden - Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, 27157, NC, USAUlf de Faire - Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, 17177, SwedenIan J Deary - Psychology, The University of Edinburgh, Edinburgh, EH8 9JZ, UKPaul Elliott - MRC-PHE Centre for Environment and Health, Imperial College London, London, W2 1PG, UKTõnu Esko - Broad Institute of the Massachusetts Institute of Technology and Harvard University, Boston, 02142, MA, USABarry I Freedman - Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, 27157, NC, USAPhilippe Froguel - Department of Genomics of Common Disease, Imperial College London, London, W12 0NN, UKPaolo Gasparini - Department of Medical Sciences, University of Trieste, Trieste, 34137, ItalyChristian Gieger - German Center for Diabetes Research (DZD e.V.), Neuherberg, 85764, GermanyNorihiro Kato - Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, 1628655, JapanMarkku Laakso - Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, 70210, FinlandTimo A Lakka - Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, 70210, FinlandTerho Lehtimäki - Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, 33014, FinlandPatrik K E Magnusson - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, 17177, SwedenAlbertine J Oldehinkel - Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, The NetherlandsBrenda W J H Penninx - Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, 1081 HV, The NetherlandsNilesh J Samani - NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, LE3 9QD, UKXiao-Ou Shu - Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, 37203, TN, USAPim van der Harst - Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, 1105 AZ, The NetherlandsJana V Van Vliet-Ostaptchouk - Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, The NetherlandsPeter Vollenweider - Internal Medicine, Department of Medicine, Lausanne University Hospital, Lausanne, 1011, SwitzerlandLynne E Wagenknecht - Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, 27157, NC, USAYa X Wang - Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, ChinaNicholas J Wareham - MRC Epidemiology Unit, University of Cambridge, Cambridge, CB2 0QQ, UKDavid R Weir - Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, 48104, MI, USATangchun Wu - Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, ChinaWei Zheng - Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, 37203, TN, USAMichele K Evans - Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, 21224, MD, USAPaul W Franks - OCDEM, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 7LE, UKVilmundur Gudnason - Faculty of Medicine, University of Iceland, Reykjavik, 101, IcelandCaroline Hayward - Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UKBernardo L Horta - Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, 96020220, RS, BrazilTanika N Kelly - Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, 70112, LA, USAYongmei Liu - Public Health Sciences, Epidemiology and Prevention, Wake Forest University Health Sciences, Winston-Salem, 27157, NC, USAKari E North - Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, 27514, NC, USAAlexandre C Pereira - Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, 01246903, SP, BrazilPaul M Ridker - Harvard Medical School, Boston, 02131, MA, USAE Shyong Tai - Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, SingaporeRob M van Dam - Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, SingaporeErvin R Fox - Cardiology, Medicine, University of Mississippi Medical Center, Jackson, 39216, MS, USASharon L R Kardia - Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, 48109, MI, USAChing-Ti Liu - Biostatistics, Boston University School of Public Health, Boston, 02118, MA, USADennis O Mook-Kanamori - Public Health and Primary Care, Leiden University Medical Center, Leiden, 2300 RC, The NetherlandsMichael A Province - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, 63108, MO, USASusan Redline - Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, 02115, MA, USACornelia M van Duijn - Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CE, The NetherlandsJerome I Rotter - The Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, 90502, CA, USACharles B Kooperberg - Fred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, 98109, WA, USAW James Gauderman - Biostatistics, Preventive Medicine, University of Southern California, Los Angeles, 90032, CA, USABruce M Psaty - Cardiovascular Health Research Unit, Epidemiology, Medicine and Health Services, University of Washington, Seattle, 98101, WA, USAPatricia B Munroe - NIHR Barts Cardiovascular Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UKMyriam Fornage - Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, 77030, TX, USAL Adrienne Cupples - NHLBI Framingham Heart Study, Framingham, 01702, MA, USACharles N Rotimi - Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, 20892, MD, USAAlanna C Morrison - Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, 77030, TX, USADabeeru C Rao - Division of Biostatistics, Washington University School of Medicine, St. Louis, 63110, MO, USA. rao@wustl.eduRuth J F Loos - Icahn School of Medicine at Mount Sinai, The Mindich Child Health and Development Institute, New York, 10029, NY, USA. ruth.loos@mssm.eduLifelines Cohort StudyCaizheng Yu - Huazhong University of Science and TechnologyKenneth Rice - University of WashingtonXiaofeng Zhu - Case Western Reserve UniversityAlison D Murray - University of Aberdeen
- Resource Type
- Journal article
- Publication Details
- Nature communications, Vol.10(1), pp.376-376
- DOI
- 10.1038/s41467-018-08008-w
- PMID
- 30670697
- PMCID
- PMC6342931
- NLM abbreviation
- Nat Commun
- ISSN
- 2041-1723
- eISSN
- 2041-1723
- Publisher
- England
- Grant note
- K01 HL135405 / NHLBI NIH HHS R01 AG055406 / NIA NIH HHS R01 DK062370 / NIDDK NIH HHS MR/L01632X/1 / Medical Research Council K01 HL136700 / NHLBI NIH HHS R01 DK072193 / NIDDK NIH HHS R01 DK107786 / NIDDK NIH HHS R56 HG010297 / NHGRI NIH HHS MR/R023484/1 / Medical Research Council P30 DK079626 / NIDDK NIH HHS R01 HL142302 / NHLBI NIH HHS MR/L01341X/1 / Medical Research Council T32 DK091317 / NIDDK NIH HHS P2C HD050924 / NICHD NIH HHS MC_UU_00007/10 / Medical Research Council U01 AG009740 / NIA NIH HHS U01 HG007417 / NHGRI NIH HHS M01 RR000032 / NCRR NIH HHS MC_UU_12015/1 / Medical Research Council R01 DK093757 / NIDDK NIH HHS R01 HL105756 / NHLBI NIH HHS R01 HL118305 / NHLBI NIH HHS R01 DK075787 / NIDDK NIH HHS U01 DK062370 / NIDDK NIH HHS P30 DK020572 / NIDDK NIH HHS P01 CA196569 / NCI NIH HHS MR/K026992/1 / Medical Research Council BB/F019394/1 / Biotechnology and Biological Sciences Research Council P30 DK056341 / NIDDK NIH HHS
- Language
- English
- Date published
- 01/22/2019
- Academic Unit
- Epidemiology; Internal Medicine
- Record Identifier
- 9983995042002771
Metrics
26 Record Views