Journal article
Multi-centre normative brain mapping of intracranial EEG lifespan patterns in the human brain
Brain structure & function, Vol.230(7), 138
09/01/2025
DOI: 10.1007/s00429-025-02988-4
PMCID: PMC12370820
PMID: 40839127
Abstract
Understanding healthy human brain function is crucial to identify and map pathological tissue within it. Whilst previous studies have mapped intracranial EEG (icEEG) from non-epileptogenic brain regions, they often neglect age and sex effects. Further, they are limited by small sample sizes due to the modality’s invasive nature. This study substantially expands the subject pool compared to existing literature, to create a multi-centre, normative map of brain activity which considers the effects of age, sex and recording hospital. Using interictal icEEG recordings from
subjects across 15 centres, we constructed a normative map of non-pathological brain activity by regressing age and sex on relative band power in five frequency bands. A linear mixed model was implemented to account for the hospital effect. Variable importance was assessed using standard statistical measures, and regression coefficients (and their standard errors) were analysed at both whole-brain and regional scales. Recording hospital significantly impacted normative icEEG maps in all frequency bands, and age was a more influential predictor of band power than sex. The age effect varied by frequency band, but no spatial patterns were observed at the region-specific level. Certainty about regression coefficients was also frequency band specific and moderately impacted by sample size. The concept of a normative map is well-established in neuroscience research and particularly relevant to the icEEG modality, which does not allow healthy control baselines. Our key results regarding the hospital site and age effect guide future work utilising normative maps in icEEG.
Details
- Title: Subtitle
- Multi-centre normative brain mapping of intracranial EEG lifespan patterns in the human brain
- Creators
- Heather Woodhouse - Newcastle UniversityGerard Hall - Newcastle UniversityCallum Simpson - Newcastle UniversityCsaba Kozma - Newcastle UniversityFrances Turner - Newcastle UniversityGabrielle M. Schroeder - Newcastle UniversityBeate Diehl - National Hospital for Neurology and NeurosurgeryJohn S. Duncan - National Hospital for Neurology and NeurosurgeryJiajie Mo - Beijing Tiantan HospitalKai Zhang - Beijing Tiantan HospitalAswin Chari - Great Ormond Street HospitalMartin Tisdall - Great Ormond Street HospitalFriederike Moeller - Great Ormond Street HospitalChris Petkov - Faculty of Medical Sciences, Newcastle University, University of Iowa Hospitals and ClinicsMatthew A. Howard - University of IowaGeorge M. Ibrahim - Hospital for Sick ChildrenElizabeth Donner - Hospital for Sick ChildrenNebras M. Warsi - Hospital for Sick ChildrenRaheel Ahmed - University of Wisconsin–MadisonPeter N. Taylor - Newcastle UniversityYujiang Wang - Newcastle University
- Resource Type
- Journal article
- Publication Details
- Brain structure & function, Vol.230(7), 138
- DOI
- 10.1007/s00429-025-02988-4
- PMID
- 40839127
- PMCID
- PMC12370820
- NLM abbreviation
- Brain Struct Funct
- ISSN
- 1863-2653
- eISSN
- 1863-2661
- Publisher
- Springer Berlin Heidelberg
- Grant note
- UL1TR002373 / National Center for Advancing Translational Sciences (https://doi.org/10.13039/100006108) MR/Y034104/1; MR/V026569/1 / UK Research and Innovation (https://doi.org/10.13039/100014013) UCLH Biomedical Research Centre (https://doi.org/10.13039/501100012317) EP/L015358/1; EP/L015358/1 / Engineering and Physical Sciences Research Council (https://doi.org/10.13039/501100000266) Epilepsy Research UK (https://doi.org/10.13039/501100000295) Abe Bresver Chair in Functional Neurosurgery at the Hospital for Sick Children
- Language
- English
- Date published
- 09/01/2025
- Academic Unit
- Neurology; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
- Record Identifier
- 9984948117702771
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