Multi-site characterization of an fMRI working memory paradigm: Reliability of activation indices

Anastasia Yendiki; Douglas N Greve; Stuart Wallace; Mark Vangel; Jeremy Bockholt; Bryon A Mueller; Vince Magnotta; Nancy Andreasen; Dara S Manoach; Randy L Gollub

doi:10.1016/j.neuroimage.2010.02.084

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Multi-site characterization of an fMRI working memory paradigm: Reliability of activation indices

Journal article

Peer reviewed

Multi-site characterization of an fMRI working memory paradigm: Reliability of activation indices

Anastasia Yendiki, Douglas N Greve, Stuart Wallace, Mark Vangel, Jeremy Bockholt, Bryon A Mueller, Vince Magnotta, Nancy Andreasen, Dara S Manoach and Randy L Gollub

NeuroImage (Orlando, Fla.), Vol.53(1), pp.119-131

10/15/2010

DOI: 10.1016/j.neuroimage.2010.02.084

PMCID: PMC3810293

PMID: 20451631

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Abstract

Neuroimaging studies are facilitated significantly when it is possible to recruit subjects and acquire data at multiple sites. However, the use of different scanners and acquisition protocols is a potential source of variability in multi-site data. In this work we present a multi-site study of the reliability of fMRI activation indices, where 10 healthy volunteers were scanned at 4 different sites while performing a working memory paradigm. Our results indicate that, even with different scanner manufacturers and field strengths, activation variability due to site differences is small compared to variability due to subject differences in this cognitive task, provided we choose an appropriate activation measure.

fMRI

Multi-center studies

SIRP

Reliability

Details

Title: Subtitle: Multi-site characterization of an fMRI working memory paradigm: Reliability of activation indices
Creators: Anastasia Yendiki - Athinoula A. Martinos Center for Biomedical Imaging, Dept. of Radiology, MGH, Dept. of Radiology, Harvard Medical School, USA
Douglas N Greve - Athinoula A. Martinos Center for Biomedical Imaging, Dept. of Radiology, MGH, Dept. of Radiology, Harvard Medical School, USA
Stuart Wallace - Athinoula A. Martinos Center for Biomedical Imaging, Dept. of Radiology, MGH, Dept. of Radiology, Harvard Medical School, USA
Mark Vangel - Athinoula A. Martinos Center for Biomedical Imaging, Dept. of Radiology, MGH, Dept. of Radiology, Harvard Medical School, USA
Jeremy Bockholt - University of New Mexico, Albuquerque, NM, USA
Bryon A Mueller - Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA
Vince Magnotta - University of Iowa, Iowa City, IA, USA
Nancy Andreasen - University of Iowa, Iowa City, IA, USA
Dara S Manoach - Athinoula A. Martinos Center for Biomedical Imaging, Dept. of Radiology, MGH, Dept. of Radiology, Harvard Medical School, USA
Randy L Gollub - Athinoula A. Martinos Center for Biomedical Imaging, Dept. of Radiology, MGH, Dept. of Radiology, Harvard Medical School, USA
Resource Type: Journal article
Publication Details: NeuroImage (Orlando, Fla.), Vol.53(1), pp.119-131
DOI: 10.1016/j.neuroimage.2010.02.084
PMID: 20451631
PMCID: PMC3810293
NLM abbreviation: Neuroimage
ISSN: 1053-8119
eISSN: 1095-9572
Publisher: Elsevier Inc
Language: English
Date published: 10/15/2010
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984003971302771

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