Journal article
Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions
American journal of epidemiology, Vol.188(6), pp.1033-1054
06/01/2019
DOI: 10.1093/aje/kwz005
PMCID: PMC6545280
PMID: 30698716
Abstract
A person's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multiancestry genome-wide association study of levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. We included 45 studies in stage 1 (genome-wide discovery) and 66 studies in stage 2 (focused follow-up), for a total of 394,584 individuals from 5 ancestry groups. Analyses covered the period July 2014-November 2017. Genetic main effects and interaction effects were jointly assessed by means of a 2-degrees-of-freedom (df) test, and a 1-df test was used to assess the interaction effects alone. Variants at 495 loci were at least suggestively associated (P < 1 × 10-6) with lipid levels in stage 1 and were evaluated in stage 2, followed by combined analyses of stage 1 and stage 2. In the combined analysis of stages 1 and 2, a total of 147 independent loci were associated with lipid levels at P < 5 × 10-8 using 2-df tests, of which 18 were novel. No genome-wide-significant associations were found testing the interaction effect alone. The novel loci included several genes (proprotein convertase subtilisin/kexin type 5 (PCSK5), vascular endothelial growth factor B (VEGFB), and apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 (APOBEC1) complementation factor (A1CF)) that have a putative role in lipid metabolism on the basis of existing evidence from cellular and experimental models.
Details
- Title: Subtitle
- Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions
- Creators
- Traci M Bartz - Cardiovascular Health Research Unit, Biostatistics and Medicine, University of Washington, Seattle, WashingtonLawrence F Bielak - Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MichiganXuan Deng - Biostatistics, Boston University School of Public Health, Boston, MassachusettsRajkumar Dorajoo - Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, SingaporeKurt K Lohman - Public Health Sciences, Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, North CarolinaAlisa K Manning - Department of Medicine, Harvard Medical School, Boston, MassachusettsTuomo Rankinen - Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LouisianaAlbert V Smith - Faculty of Medicine, University of Iceland, Reykjavik, IcelandSalman M Tajuddin - Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MarylandEvangelos Evangelou - Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, GreeceMariaelisa Graff - Epidemiology, University of North Carolina Gilling School of Global Public Health, Chapel Hill, North CarolinaMaris Alver - Estonian Genome Center, University of Tartu, Tartu, EstoniaMathilde Boissel - CNRS UMR 8199, European Genomic Institute for DiabetesJin Fang Chai - Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, SingaporeXu Chen - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, SwedenJasmin Divers - Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North CarolinaIlaria Gandin - Department of Medical Sciences, University of Trieste, Trieste, ItalyChuan Gao - Molecular Genetics and Genomics Program, Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston-Salem, North CarolinaAnuj Goel - Wellcome Centre for Human Genetics, University of Oxford, Oxford, Oxfordshire, United KingdomYanick Hagemeijer - Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The NetherlandsSarah E Harris - Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, United KingdomFernando P Hartwig - Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United KingdomMeian He - Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaAndrea R V R Horimoto - Laboratory of Genetics and Molecular Cardiology, Heart InstituteFang-Chi Hsu - Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North CarolinaAnne U Jackson - Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MichiganAnuradhani Kasturiratne - Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri LankaPirjo Komulainen - Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, FinlandBrigitte Kühnel - Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, GermanyFederica Laguzzi - Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SwedenJoseph H Lee - Sergievsky Center and Taub Institute, Columbia University Medical Center, New York, New YorkJian'an Luan - MRC Epidemiology Unit, University of Cambridge, Cambridge, United KingdomLeo-Pekka Lyytikäinen - Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandNana Matoba - Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama, JapanIlja M Nolte - Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The NetherlandsMaik Pietzner - DZHKMuhammad Riaz - NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United KingdomM Abdullah Said - Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The NetherlandsRobert A Scott - MRC Epidemiology Unit, University of Cambridge, Cambridge, United KingdomTamar Sofer - Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MassachusettsAlena Stančáková - Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, FinlandFumihiko Takeuchi - Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, JapanBamidele O Tayo - Department of Public Health Sciences, Loyola University Chicago, Maywood, IllinoisPeter J van der Most - Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The NetherlandsTibor V Varga - Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, SwedenYajuan Wang - Department of Population and Quantitative Health and Sciences, Case Western Reserve University, Cleveland, OhioErin B Ware - Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MichiganWanqing Wen - Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TennesseeLisa R Yanek - Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MarylandWeihua Zhang - Department of Cardiology, Ealing Hospital, Middlesex, United KingdomJing Hua Zhao - MRC Epidemiology Unit, University of Cambridge, Cambridge, United KingdomSaima Afaq - Department of Epidemiology and Biostatistics, Imperial College London, London, United KingdomNajaf Amin - Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The NetherlandsMarzyeh Amini - Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The NetherlandsDan E Arking - McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MarylandTin Aung - Ophthalmology & Visual Sciences Academic Clinical ProgramChristie Ballantyne - Houston Methodist Debakey Heart and Vascular Center, Houston, TexasEric Boerwinkle - Human Genome Sequencing Center, Baylor College of Medicine, Houston, TexasUlrich Broeckel - Section of Genomic Pediatrics, Department of Pediatrics, Medicine and Physiology, Medical College of Wisconsin, Milwaukee, WisconsinArchie Campbell - Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, United KingdomMickaël Canouil - CNRS UMR 8199, European Genomic Institute for DiabetesHans J Grabe - Department Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, GermanyQing Duan - Department of Genetics, University of North Carolina, Chapel Hill, North CarolinaSabanayagam Charumathi - Centre for Quantitative Medicine, Academic Medicine Research Institute, Ophthalmology & Visual Sciences Academic Clinical ProgramMegan L Grove - Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TexasCharles B Eaton - Department of Family Medicine and Epidemiology, Alpert Medical School of Brown University, Providence, Rhode IslandYii-Der Ida Chen - Genomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LA BioMed at Harbor-UCLA Medical Center, Torrance, CaliforniaC Charles Gu - Division of Biostatistics, Washington University School of Medicine, St. Louis, MissouriCraig Johnson - Collaborative Health Studies Coordinating Center, University of Washington, Seattle, WashingtonJohn M Connell - Ninewells Hospital & Medical School, University of Dundee, Dundee, Scotland, United KingdomTamara B Harris - Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, MarylandRuben N Eppinga - Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The NetherlandsJost Bruno Jonas - Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Capital Medical University, Beijing, ChinaUlf de Faire - Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SwedenSami Heikkinen - Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, FinlandJessica D Faul - Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MichiganLisa de Las Fuentes - Cardiovascular Division, Department of Medicine, Washington University, St. Louis, MissouriChew-Kiat Heng - Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, SingaporeRenée de Mutsert - Clinical Epidemiology, Leiden University Medical Center, Leiden, NetherlandsMakoto Hirata - Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato-ku, JapanCandace M Kammerer - Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PennsylvaniaH Janaka de Silva - Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri LankaJames E Hixson - Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health, Houston, TexasVirginia Fisher - Biostatistics, Boston University School of Public Health, Boston, MassachusettsTomohiro Katsuya - Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, JapanJingzhong Ding - Center on Diabetes, Obesity, and Metabolism, Gerontology and Geriatric Medicine, Wake Forest University Health Sciences, Winston-Salem, North CarolinaBarbara V Howard - Center for Clinical and Translational Sciences and Department of Medicine, Georgetown-Howard Universities, Washington, District of ColumbiaAnna F Dominiczak - Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United KingdomM Arfan Ikram - Department of Neurology, Erasmus University Medical Center, Rotterdam, The NetherlandsTerrence Forrester - Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, JamaicaChiea Chuen Khor - Department of Biochemistry, National University of Singapore, Singapore, SingaporeOscar H Franco - Institute of Social and Preventive MedicineTuomas O Kilpeläinen - Department of Environmental Medicine and Public Health, The Icahn School of Medicine at Mount Sinai, New York, New YorkYechiel Friedlander - Braun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem, IsraelWoon-Puay Koh - Duke-NUS Medical School, Singapore, SingaporeMohsen Ghanbari - Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranHeikki A Koistinen - Minerva Foundation Institute for Medical Research, Helsinki, FinlandFranco GiulianiniIvana KolcicCharles Kooperberg - Fred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, WashingtonJose E Krieger - Laboratory of Genetics and Molecular Cardiology, Heart InstituteSteve B Kritchevsky - Sticht Center for Health Aging and Alzheimer's Prevention, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North CarolinaMichiaki Kubo - Center for Integrative Medical Sciences, RIKEN, Yokohama, JapanJohanna Kuusisto - Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, FinlandTimo A Lakka - Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, FinlandCarl D Langefeld - Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North CarolinaClaudia Langenberg - MRC Epidemiology Unit, University of Cambridge, Cambridge, United KingdomLenore J Launer - Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, MarylandBenjamin Lehne - Department of Epidemiology and Biostatistics, Imperial College London, London, United KingdomRozenn N Lemaitre - Cardiovascular Health Research Unit, Medicine, University of Washington, Seattle, WashingtonJingjing Liang - Department of Population and Quantitative Health and Sciences, Case Western Reserve University, Cleveland, OhioJianjun Liu - Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeKiang Liu - Epidemiology, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IllinoisMarie Loh - Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research, SingaporeTin Louie - Department of Biostatistics, University of Washington, Seattle, WashingtonReedik Mägi - Estonian Genome Center, University of Tartu, Tartu, EstoniaAni W Manichaikul - Biostatistics Section, Center for Public Health Genomics, University of Virginia, School of Medicine, West Complex, Charlottesville, VirginiaColin A McKenzie - Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, JamaicaThomas Meitinger - Institute of Human Genetics, Technische Universität München, Munich, GermanyAndres Metspalu - Estonian Genome Center, University of Tartu, Tartu, EstoniaYuri Milaneschi - Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, The NetherlandsLili Milani - Estonian Genome Center, University of Tartu, Tartu, EstoniaKaren L Mohlke - Department of Genetics, University of North Carolina, Chapel Hill, North CarolinaThomas H Mosley - Geriatrics, Medicine, University of Mississippi Medical Center, Jackson, MississippiKenneth J Mukamal - General Medicine & Primary Care, Medicine, Beth Israel Deaconess Medical Center, Boston, MassachusettsMike A Nalls - Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MarylandMatthias Nauck - DZHKChristopher P Nelson - NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United KingdomNona Sotoodehnia - Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, WashingtonJeff R O'Connell - Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MarylandNicholette D Palmer - Biochemistry, Wake Forest School of Medicine, Winston-Salem, North CarolinaRaha Pazoki - Department of Epidemiology and Biostatistics, Imperial College London, London, United KingdomNancy L Pedersen - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, SwedenAnnette Peters - DZHKPatricia A Peyser - Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MichiganOzren Polasek - Gen-info Ltd, Zagreb, CroatiaNeil Poulter - School of Public Health, Imperial College London, London, United KingdomLeslie J Raffel - Division of Genetic and Genomic Medicine, Department of Pediatrics, University of California, Irvine, CaliforniaYih Chung Tham - Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, SingaporeYik Ying Teo - Department of Statistics and Applied Probability, National University of Singapore, Singapore, SingaporeAlex P Reiner - Fred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, WashingtonTreva K Rice - Division of Biostatistics, Washington University School of Medicine, St. Louis, MissouriAndré G Uitterlinden - Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The NetherlandsStephen S Rich - Center for Public Health Genomics, University of Virginia, School of Medicine, West Complex, Charlottesville, VirginiaDiana van Heemst - Internal Medicine, Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The NetherlandsAntonietta Robino - Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, ItalyDragana Vuckovic - Department of Medical Sciences, University of Trieste, Trieste, ItalyJennifer G Robinson - Department of Epidemiology and Medicine, University of Iowa, Iowa City, IowaMelanie Waldenberger - Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, GermanyLynda M Rose - Preventive Medicine, Brigham and Women's Hospital, Boston, MassachusettsLihua Wang - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MissouriIgor Rudan - Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United KingdomYujie Wang - University of North Carolina at Chapel HillZhe Wang - The University of Texas Health Science Center at HoustonCarsten O Schmidt - Institute for Community Medicine, University Medicine Greifswald, Greifswald, GermanyPamela J Schreiner - Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MinnesotaWen Bin Wei - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, ChinaPeter Sever - National Heart and Lung Institute, Imperial College London, London, United KingdomOlli T Raitakari - Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, FinlandChristine Williams - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MissouriYuan Shi - Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, SingaporeGregory Wilson - Jackson Heart Study, School of Public Health, Jackson State University, Jackson, MississippiStephen Sidney - Division of Research, Kaiser Permanente of Northern California, Oakland, CaliforniaMary K Wojczynski - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MissouriMario Sims - Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MississippiJie Yao - Genomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LA BioMed at Harbor-UCLA Medical Center, Torrance, CaliforniaBlair H Smith - Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, United KingdomJennifer A Smith - Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MichiganHarold Snieder - Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The NetherlandsJian-Min Yuan - Division of Cancer Control and Population Sciences, UPMC Hillman Cancer, University of Pittsburgh, Pittsburgh, PennsylvaniaJohn M Starr - Alzheimer Scotland Dementia Research Centre, The University of Edinburgh, Edinburgh, United KingdomWei Zhao - Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MichiganKonstantin Strauch - Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU, Munich, GermanyAlan B Zonderman - Behavioral Epidemiology Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MarylandNicholas Tan - Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeDiane M Becker - Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MarylandBrenda Penninx - Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, The NetherlandsKent D Taylor - Genomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LA BioMed at Harbor-UCLA Medical Center, Torrance, CaliforniaMichael Boehnke - Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MichiganAmy R Bentley - Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MarylandDonald W Bowden - Biochemistry, Wake Forest School of Medicine, Winston-Salem, North CarolinaAlexandre C Pereira - Laboratory of Genetics and Molecular Cardiology, Heart InstituteJohn C Chambers - NIHR Imperial College Biomedical Research Centre, Imperial College London, London, United KingdomYun J Sung - Division of Biostatistics, Washington University School of Medicine, St. Louis, MissouriIan J Deary - Psychology, The University of Edinburgh, Edinburgh, United KingdomRainer Rauramaa - Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, FinlandTõnu Esko - Broad Institute of the Massachusetts Institute of Technology and Harvard University, Boston, MassachusettsThomas W Winkler - Department of Genetic Epidemiology, University of Regensburg, Regensburg, GermanyMartin Farrall - Wellcome Centre for Human Genetics, University of Oxford, Oxford, Oxfordshire, United KingdomNilesh J Samani - NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United KingdomPaul W Franks - OCDEM, Radcliffe Department of Medicine, University of Oxford, Oxford, United KingdomIoanna Ntalla - Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United KingdomBarry I Freedman - Nephrology, Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North CarolinaXiao-Ou Shu - Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TennesseePhilippe Froguel - Department of Genomics of Common Disease, Imperial College London, London, United KingdomKaren Schwander - Division of Biostatistics, Washington University School of Medicine, St. Louis, MissouriPaolo Gasparini - Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, ItalyMichael R Brown - Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TexasPim van der Harst - Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The NetherlandsChristian Gieger - German Center for Diabetes ResearchAldi T Kraja - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MissouriLynne E Wagenknecht - Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North CarolinaBernardo L Horta - Postgraduate Programme in Epidemiology, Federal University of Pelotas, Pelotas, RS, BrazilYoichiro Kamatani - Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama, JapanXiuqing Guo - Genomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LA BioMed at Harbor-UCLA Medical Center, Torrance, CaliforniaNorihiro Kato - Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, JapanYa Xing Wang - Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, ChinaJaspal S Kooner - NIHR Imperial College Biomedical Research Centre, Imperial College London, London, United KingdomNora Franceschini - Epidemiology, University of North Carolina Gilling School of Global Public Health, Chapel Hill, North CarolinaMarkku Laakso - Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, FinlandNicholas J Wareham - MRC Epidemiology Unit, University of Cambridge, Cambridge, United KingdomKarin Leander - Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SwedenChing-Yu Cheng - Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeHugh Watkins - Wellcome Centre for Human Genetics, University of Oxford, Oxford, Oxfordshire, United KingdomTerho Lehtimäki - Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandDavid R Weir - Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MichiganPaul S de Vries - Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TexasPatrik K E Magnusson - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, SwedenXueling Sim - Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, SingaporeAnanda R Wickremasinghe - Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri LankaDina Vojinovic - Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The NetherlandsJennifer E Huffman - Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United KingdomWei Zheng - Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TennesseeSolomon K Musani - Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MississippiPaul Elliott - UK Dementia Research InstituteChangwei Li - Epidemiology and Biostatistics, University of Georgia at Athens College of Public Health, Athens, GeorgiaKari E North - Carolina Center of Genome Sciences, University of North Carolina, Chapel Hill, North CarolinaMary F Feitosa - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MissouriClaude Bouchard - Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LouisianaMelissa A Richard - Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TexasMichele K Evans - Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MarylandRaymond Noordam - Internal Medicine, Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The NetherlandsVilmundur Gudnason - Faculty of Medicine, University of Iceland, Reykjavik, IcelandChing-Ti Liu - Biostatistics, Boston University School of Public Health, Boston, MassachusettsHugues Aschard - Centre de Bioinformatique, Biostatistique et Biologie IntégrativeYongmei Liu - Public Health Sciences, Epidemiology and Prevention, Wake Forest University Health Sciences, Winston-Salem, North CarolinaBruce M Psaty - Kaiser Permanente Washington, Health Research Institute, Seattle, WashingtonPaul M Ridker - Harvard Medical School, Boston, MassachusettsRob M van Dam - Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeSharon L R Kardia - Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MichiganXiaofeng Zhu - Department of Population and Quantitative Health and Sciences, Case Western Reserve University, Cleveland, OhioCharles N Rotimi - Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MarylandDennis O Mook-Kanamori - Public Health and Primary Care, Leiden University Medical Center, Leiden, LeidenMyriam Fornage - Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TexasTanika N Kelly - Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LouisianaErvin R Fox - Cardiology, Medicine, University of Mississippi Medical Center, Jackson, MississippiCaroline Hayward - Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United KingdomCornelia M van Duijn - Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The NetherlandsE Shyong Tai - Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeTien Yin Wong - Ophthalmology & Visual Sciences Academic Clinical ProgramJingmin Liu - WHI CCC, Fred Hutchinson Cancer Research Center, Seattle, WashingtonJerome I Rotter - Genomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LA BioMed at Harbor-UCLA Medical Center, Torrance, CaliforniaW James Gauderman - Biostatistics, Preventive Medicine, University of Southern California, Los Angeles, CaliforniaMichael A Province - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MissouriPatricia B Munroe - NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, United KingdomKenneth Rice - Department of Biostatistics, University of Washington, Seattle, WashingtonDaniel I Chasman - Harvard Medical School, Boston, MassachusettsL Adrienne Cupples - NHLBI Framingham Heart Study, Framingham, MassachusettsDabeeru C Rao - Division of Biostatistics, Washington University School of Medicine, St. Louis, MissouriAlanna C Morrison - Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TexasWilliam R ScottJames Scott - Imperial College LondonInterAct ConsortiumCaizheng Yu - Huazhong University of Science and TechnologyBing Yu - The University of Texas Health Science Center at HoustonYize Li - Washington University in St. LouisDavid R Jacobs - University of Minnesota
- Resource Type
- Journal article
- Publication Details
- American journal of epidemiology, Vol.188(6), pp.1033-1054
- Publisher
- United States
- DOI
- 10.1093/aje/kwz005
- PMID
- 30698716
- PMCID
- PMC6545280
- ISSN
- 1476-6256
- eISSN
- 1476-6256
- Grant note
- SP/04/002 / British Heart Foundation R01 HL045670 / NHLBI NIH HHS N01HC95169 / NHLBI NIH HHS N01HC65235 / NHLBI NIH HHS R01 DK062370 / NIDDK NIH HHS R01 AG055406 / NIA NIH HHS R01 DK072193 / NIDDK NIH HHS U01 HG004402 / NHGRI NIH HHS ZIA HG000024 / Intramural NIH HHS R01 HL067348 / NHLBI NIH HHS R01 HL085251 / NHLBI NIH HHS R01 HL059684 / NHLBI NIH HHS R01 NS062059 / NINDS NIH HHS R01 HL119443 / NHLBI NIH HHS R03 AG046389 / NIA NIH HHS U10 HL054472 / NHLBI NIH HHS N01HC95163 / NHLBI NIH HHS N01HC95166 / NHLBI NIH HHS R01 HL071025 / NHLBI NIH HHS R01 HL103612 / NHLBI NIH HHS U10 HL054464 / NHLBI NIH HHS MR/K002414/1 / Medical Research Council MC_UP_1605/7 / Medical Research Council N01 AG062106 / NIA NIH HHS U01 AG009740 / NIA NIH HHS HHSN268201300025C / NHLBI NIH HHS G0601966 / Medical Research Council HHSN268201100010C / NHLBI NIH HHS HHSN268201100005C / NHLBI NIH HHS R01 HL059367 / NHLBI NIH HHS Z01 HG200362 / Intramural NIH HHS R01 DK101855 / NIDDK NIH HHS HHSN268201500001I / NHLBI NIH HHS U01 HG004446 / NHGRI NIH HHS U01 HL054495 / NHLBI NIH HHS UM1 CA173640 / NCI NIH HHS R01 HL090682 / NHLBI NIH HHS R01 HL055673 / NHLBI NIH HHS HHSN268201300049C / NHLBI NIH HHS HHSN268201100005I / NHLBI NIH HHS PG/02/128 / British Heart Foundation U01 HG004424 / NHGRI NIH HHS M01 RR007122 / NCRR NIH HHS R01 HL080467 / NHLBI NIH HHS R01 HL049762 / NHLBI NIH HHS U10 HL054497 / NHLBI NIH HHS P30 DK063491 / NIDDK NIH HHS R01 HL087652 / NHLBI NIH HHS U01 HL054509 / NHLBI NIH HHS HHSN271201100004C / NIA NIH HHS Wellcome Trust U01 HL080295 / NHLBI NIH HHS R01 HL120393 / NHLBI NIH HHS BHF/RG/2000004 / British Heart Foundation N01HC95161 / NHLBI NIH HHS R01 HL087698 / NHLBI NIH HHS UM1 CA182876 / NCI NIH HHS N01HC85083 / NHLBI NIH HHS U01 HL054481 / NHLBI NIH HHS HHSN268201100012C / NHLBI NIH HHS R01 DK085175 / NIDDK NIH HHS N01HC65237 / NHLBI NIH HHS N01HC95167 / NHLBI NIH HHS U01 HL054457 / NHLBI NIH HHS R01 HL117078 / NHLBI NIH HHS R01 AG023629 / NIA NIH HHS R01 HL043851 / 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NCATS NIH HHS U01 AG023746 / NIA NIH HHS U10 HL054509 / NHLBI NIH HHS HHSN268200800007C / NHLBI NIH HHS N01HC55222 / NHLBI NIH HHS MC_UU_00007/10 / Medical Research Council N01AG12100 / NIA NIH HHS R01 LM010098 / NLM NIH HHS HHSN268201300029C / NHLBI NIH HHS N01 AG062101 / NIA NIH HHS R01 DK093757 / NIDDK NIH HHS Z01 AG000513 / Intramural NIH HHS R01 HL053353 / NHLBI NIH HHS HHSN268201100008C / NHLBI NIH HHS N01HC65234 / NHLBI NIH HHS R01 CA047988 / NCI NIH HHS R01 HL105756 / NHLBI NIH HHS U01 DK062370 / NIDDK NIH HHS R01 HL087660 / NHLBI NIH HHS U10 HL054457 / NHLBI NIH HHS HHSN268201300028C / NHLBI NIH HHS HHSN268201300050C / NHLBI NIH HHS MR/K026992/1 / Medical Research Council R01 HL087641 / NHLBI NIH HHS R01 HL071205 / NHLBI NIH HHS HHSN268201100009C / NHLBI NIH HHS R01 MD012765 / NIMHD NIH HHS HHSN268201100009I / NHLBI NIH HHS
- Language
- English
- Date published
- 06/01/2019
- Academic Unit
- Epidemiology; Internal Medicine
- Record Identifier
- 9983995127102771
Metrics
76 Record Views