Journal article
Multicenter Repeatability and Reproducibility of MR Fingerprinting in Phantoms and in Prostatic Tissue
Magnetic resonance in medicine, Vol.88(4), pp.1818-1827
10/2022
DOI: 10.1002/mrm.29264
PMCID: PMC9469467
PMID: 35713379
Abstract
Purpose To evaluate multicenter repeatability and reproducibility of T-1 and T-2 maps generated using MR fingerprinting (MRF) in the International Society for Magnetic Resonance in Medicine/National Institute of Standards and Technology MRI system phantom and in prostatic tissues. Methods MRF experiments were performed on 5 different 3 Tesla MRI scanners at 3 different institutions: University Hospitals Cleveland Medical Center (Cleveland, OH), Brigham and Women's Hospital (Boston, MA) in the United States, and Diagnosticos da America (Rio de Janeiro, RJ) in Brazil. Raw MRF data were reconstructed using a Gadgetron-based MRF online reconstruction pipeline to yield quantitative T-1 and T-2 maps. The repeatability of T-1 and T-2 values over 6 measurements in the International Society for Magnetic Resonance in Medicine/National Institute of Standards and Technology MRI system phantom was assessed to demonstrate intrascanner variation. The reproducibility between the 4 clinical scanners was assessed to demonstrate interscanner variation. The same-day test-retest normal prostate mean T-1 and T-2 values from peripheral zone and transitional zone were also compared using the intraclass correlation coefficient and Bland-Altman analysis. Results The intrascanner variation of values measured using MRF was less than 2% for T-1 and 4.7% for T-2 for relaxation values, within the range of 307.7 to 2360 ms for T-1 and 19.1 to 248.5 ms for T-2. Interscanner measurements showed that the T-1 variation was less than 4.9%, and T-2 variation was less than 8.1% between multicenter scanners. Both T-1 and T-2 values in in vivo prostatic tissue demonstrated high test-retest reliability (intraclass correlation coefficient > 0.92) and strong linear correlation (R-2 > 0.840). Conclusion Prostate MRF measurements of T-1 and T-2 are repeatable and reproducible between MRI scanners at different centers on different continents for the above measurement ranges.
Details
- Title: Subtitle
- Multicenter Repeatability and Reproducibility of MR Fingerprinting in Phantoms and in Prostatic Tissue
- Creators
- Wei-Ching Lo - Case Western Reserve UniversityLeonardo Kayat Bittencourt - Case Western Reserve UniversityAnanya Panda - Mayo ClinicYun Jiang - University of MichiganJunichi Tokuda - Harvard UniversityRavi Seethamraju - Siemens Healthcare (United States)Clare Tempany-Afdhal - Harvard UniversityVerena Obmann - University Hospital of BernKatherine Wright - University of MichiganMark Griswold - Case Western Reserve UniversityNicole Seiberlich - University of MichiganVikas Gulani - University of Michigan
- Resource Type
- Journal article
- Publication Details
- Magnetic resonance in medicine, Vol.88(4), pp.1818-1827
- DOI
- 10.1002/mrm.29264
- PMID
- 35713379
- PMCID
- PMC9469467
- NLM abbreviation
- Magn Reson Med
- ISSN
- 0740-3194
- eISSN
- 1522-2594
- Publisher
- Wiley
- Number of pages
- 10
- Grant note
- 1C06RR12463-01 / National Center for Research Resources; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) P41 EB 015898 / National Institute of Biomedical Imaging and Bioengineering; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Biomedical Imaging & Bioengineering (NIBIB) 1R01CA208236; 1R01EB016728; R01DK098503; R01EB020667; R01HL094557 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Siemens Healthineers
- Language
- English
- Date published
- 10/2022
- Academic Unit
- Radiology
- Record Identifier
- 9984697728302771
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