Journal article
Multicenter Study of Outcomes Among Persons With HIV Who Presented to US Emergency Departments With Suspected SARS-CoV-2
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, Vol.88(4), pp.406-413
12/01/2021
DOI: 10.1097/QAI.0000000000002795
PMCID: PMC8547584
PMID: 34483295
Abstract
Background: There is a need to characterize patients with HIV with suspected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Setting: Multicenter registry of patients from 116 emergency departments in 27 US states. Methods: Planned secondary analysis of patients with suspected SARS-CoV-2, with (n = 415) and without (n = 25,306) HIV. Descriptive statistics were used to compare patient information and clinical characteristics by SARS-CoV-2 and HIV status. Unadjusted and multivariable models were used to explore factors associated with death, intubation, and hospital length of stay. Kaplan-Meier curves were used to estimate survival by SARS-CoV-2 and HIV infection status. Results: Patients with both SARS-CoV-2 and HIV and patients with SARS-CoV-2 but without HIV had similar admission rates (62.7% versus 58.6%, P = 0.24), hospitalization characteristics [eg, rates of admission to the intensive care unit from the emergency department (5.0% versus 6.3%, P = 0.45) and intubation (10% versus 13.3%, P = 0.17)], and rates of death (13.9% versus 15.1%, P = 0.65). They also had a similar cumulative risk of death (log-rank P = 0.72). However, patients with both HIV and SARS-CoV-2 infections compared with patients with HIV but without SAR-CoV-2 had worsened outcomes, including increased mortality (13.9% versus 5.1%, P < 0.01, log-rank P < 0.0001) and their deaths occurred sooner (median 11.5 versus 34 days, P < 0.01). Conclusions: Among emergency department patients with HIV, clinical outcomes associated with SARS-CoV-2 infection are not worse when compared with patients without HIV, but SARS-CoV-2 infection increased the risk of death in patients with HIV.
Details
- Title: Subtitle
- Multicenter Study of Outcomes Among Persons With HIV Who Presented to US Emergency Departments With Suspected SARS-CoV-2
- Creators
- Christopher L. Bennett - The Ohio State University Wexner Medical CenterEmmanuel Ogele - John H. Stroger, Jr. Hospital of Cook CountyNicholas R. Pettit - Indiana UniversityJason J. Bischof - The Ohio State University Wexner Medical CenterTong Meng - Stanford University School of MedicinePrasanthi Govindarajan - Stanford UniversityKristen Nordenholz - University of Colorado DenverCarlos A Camargo Jr - Harvard Medical SchoolJeffrey A. Kline - Indiana UniversityRECOVER Investigators
- Contributors
- Hans House (Contributor) - University of Iowa, Emergency Medicine
- Resource Type
- Journal article
- Publication Details
- JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, Vol.88(4), pp.406-413
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1097/QAI.0000000000002795
- PMID
- 34483295
- PMCID
- PMC8547584
- ISSN
- 1525-4135
- eISSN
- 2331-6993
- Number of pages
- 8
- Grant note
- Department of Emergency Medicine at Indiana University School of Medicine
- Language
- English
- Date published
- 12/01/2021
- Academic Unit
- Emergency Medicine
- Record Identifier
- 9984297141102771
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