Journal article
Multicenter Study of Survival Benefit of Cardiac Resynchronization Therapy in Pediatric and Congenital Heart Disease
JACC. Clinical electrophysiology, Vol.10(3), pp.539-550
03/2024
DOI: 10.1016/j.jacep.2023.11.008
PMID: 38206260
Abstract
Evidence for the efficacy of cardiac resynchronization therapy (CRT) in pediatric and congenital heart disease (CHD) has been limited to surrogate outcomes.
This study aimed to assess the impact of CRT upon the risk of transplantation or death in a retrospective, high-risk, controlled cohort at 5 quaternary referral centers.
Both CRT patients and control patients were <21 years of age or had CHD; had systemic ventricular ejection fraction <45%; symptomatic heart failure; and significant electrical dyssynchrony (QRS duration z score >3 or single-site ventricular pacing >40%) at enrollment. Patients with CRT were matched with control patients via 1:1 propensity score matching. CRT patients were enrolled at CRT implantation; control patients were enrolled at the outpatient clinical encounter where inclusion criteria were first met. The primary endpoint was transplantation or death.
In total, 324 control patients and 167 CRT recipients were identified. Mean follow-up was 4.2 ± 3.7 years. Upon propensity score matching, 139 closely matched pairs were identified (20 baseline indices). Of the 139 matched pairs, 52 (37.0%) control patients and 31 (22.0%) CRT recipients reached the primary endpoint. On both unadjusted and multivariable Cox regression analysis, the risk reduction associated with CRT for the primary endpoint was significant (HR: 0.40; 95% CI: 0.25-0.64; P < 0.001; and HR: 0.44; 95% CI: 0.28-0.71; P = 0.001, respectively). On longitudinal assessment, the CRT group had significantly improved systemic ventricular ejection fraction (P < 0.001) and shorter QRS duration (P = 0.015), sustained to 5 years.
In pediatric and CHD patients with symptomatic systolic heart failure and electrical dyssynchrony, CRT was associated with improved heart transplantation-free survival.
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Details
- Title: Subtitle
- Multicenter Study of Survival Benefit of Cardiac Resynchronization Therapy in Pediatric and Congenital Heart Disease
- Creators
- Henry Chubb - Stanford UniversityDouglas Y. Mah - Harvard UniversityMaully Shah - Children's Hospital of PhiladelphiaKimberly Y. Lin - University of PennsylvaniaDavid M. Peng - University of Michigan–Ann ArborBenjamin W. Hale - C. S. Mott Children's HospitalLindsay May - Primary Children's HospitalSusan Etheridge - Primary Children's HospitalWilliam Goodyer - Stanford UniversityScott R. Ceresnak - Stanford UniversityKara S. Motonaga - Stanford UniversityDavid N. Rosenthal - Stanford UniversityChristopher S. Almond - Stanford UniversityDoff B. McElhinney - Stanford UniversityAnne M. Dubin - Stanford University
- Resource Type
- Journal article
- Publication Details
- JACC. Clinical electrophysiology, Vol.10(3), pp.539-550
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.jacep.2023.11.008
- PMID
- 38206260
- ISSN
- 2405-500X
- eISSN
- 2405-5018
- Number of pages
- 12
- Language
- English
- Date published
- 03/2024
- Academic Unit
- Cardiology; Stead Family Department of Pediatrics
- Record Identifier
- 9984701557102771
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