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Multicenter collaboration in observational research: improving generalizability and efficiency
Journal article   Peer reviewed

Multicenter collaboration in observational research: improving generalizability and efficiency

Sheila Sprague, Joel M Matta, Mohit Bhandari, David Dodgin, Charles R Clark, Phil Kregor, Gary Bradley and Lester Little
Journal of bone and joint surgery. American volume, Vol.91 Suppl 3(Supplement_3 Suppl 3), pp.80-86
05/2009
DOI: 10.2106/JBJS.H.01623
PMID: 19411504

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Abstract

Utilizing a multicenter approach in observational clinical research allows for improved generalizability of the results, a larger sample size, and, consequently, improved efficiency. This paper highlights important issues with regard to the organization of multicenter observational studies in orthopaedic research. Specifically, we emphasize the development of trial committees, stress the importance of having a methods center for the purpose of coordinating day-to-day study activities, and describe the roles of the participating clinical sites. The successful conduct of multicenter studies requires careful study organization, a dedicated and experienced methods center, and motivated participating surgeons and study staff at the clinical sites. To illustrate the organization of a multicenter initiative, we use the example of a total hip arthroplasty collaborative.
 Multicenter Studies as Topic Humans Orthopedics Cooperative Behavior Observation Biomedical Research - methods Clinical Trials as Topic Research Design

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