Journal article
Multicentre retrospective study of intravascular large B-cell lymphoma treated at academic institutions within the United States
British journal of haematology, Vol.186(2), pp.255-262
07/2019
DOI: 10.1111/bjh.15923
PMCID: PMC8989046
PMID: 31044423
Abstract
Intravascular large B-cell lymphoma (IVLBCL) is a rare entity, with a generally aggressive course that may vary based on geographic presentation. While a United States (US) registry study showed relatively good outcomes with IVLBCL, clinicopathological and treatment data were unavailable. We performed a detailed retrospective review of cases identified at 8 US medical centres, to improve understanding of IVLBCL and inform management. We compiled data retrieved via an Institutional Review Board-approved review of IVLBCL cases identified from 1999 to 2015 at nine academic institutions across the US. We characterized the cohort's clinical status at time of diagnosis, presenting diagnostic and clinical features of the disease, treatment modalities used and overall prognostic data. Our cohort consisted of 54 patients with varying degrees of clinical features. Adjusting for age, better performance status at presentation was associated with increased survival time for the patients diagnosed in vivo (hazard ratio: 2·12, 95% confidence interval 1·28, 3·53). Based on the data we have collected, it would appear that the time interval to diagnosis is a significant contributor to outcomes of patients with IVLBCL.
Details
- Title: Subtitle
- Multicentre retrospective study of intravascular large B-cell lymphoma treated at academic institutions within the United States
- Creators
- Marcus Geer - University of Michigan–Ann ArborEmily Roberts - University of Michigan–Ann ArborMaryann Shango - Swedish Cancer InstituteBrian G Till - Fred Hutch Cancer CenterStephen D Smith - University of WashingtonHashim Abbas - Cleveland ClinicBrian T Hill - Cleveland ClinicJason Kaplan - Northwestern UniversityPaul M Barr - University of RochesterPaolo Caimi - University Hospitals of ClevelandDeborah M Stephens - Huntsman Cancer InstituteEmily Lin - City Of Hope National Medical CenterAlex F Herrera - City Of Hope National Medical CenterEvan Rosenbaum - Columbia UniversityJennifer E Amengual - Columbia University Irving Medical CenterPhilip S Boonstra - University of Michigan–Ann ArborSumana Devata - University of Michigan–Ann ArborRyan A Wilcox - University of Michigan–Ann ArborMark S Kaminski - University of Michigan–Ann ArborTycel J Phillips - University of Michigan–Ann Arbor
- Resource Type
- Journal article
- Publication Details
- British journal of haematology, Vol.186(2), pp.255-262
- DOI
- 10.1111/bjh.15923
- PMID
- 31044423
- PMCID
- PMC8989046
- ISSN
- 0007-1048
- eISSN
- 1365-2141
- Grant note
- P30 CA046592 / NCI NIH HHS
- Language
- English
- Date published
- 07/2019
- Academic Unit
- Biostatistics
- Record Identifier
- 9984274822302771
Metrics
13 Record Views