Multidrug resistance in fungi

Kailash Gulshan; W Scott Moye-Rowley

doi:10.1128/EC.00254-07

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Journal article

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Peer reviewed

Multidrug resistance in fungi

Kailash Gulshan and W Scott Moye-Rowley

Eukaryotic cell, Vol.6(11), pp.1933-1942

11/2007

DOI: 10.1128/EC.00254-07

PMCID: PMC2168405

PMID: 17873085

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Abstract

Multidrug resistance is a problem in chemotherapy in situations ranging from bacterial infections to cancer. Fungal drug resistance is an especially acute issue due to the limited number of antifungal compounds (60). Understanding the regulation and function of multidrug resistance pathways in fungi is still very much a work in progress, but its importance continues to grow with the increasing number of immunocompromised patients worldwide and their increasing reliance on chemotherapy to control fungal infections (see references 84 and 118 for recent reviews). Much of our current understanding of the molecular basis of fungal multidrug resistance springs from work in the typically nonpathogenic yeast S. cerevisiae. However, rapid advances in the experimental tractability of pathogenic fungi such as the Candida and Aspergillus species will bring the pathways in these clinically important organisms into focus. This is an important goal since the systems used for drug resistance in these pathogens share some similarity with those in S. cerevisiae but have important differences that can only be uncovered in the native organism. Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Drug Resistance, Multiple, Fungal

Fungi - genetics

Fungi - metabolism

Gene Expression Regulation, Fungal

Homeostasis

Membrane Transport Proteins - metabolism

Sphingolipids - metabolism

Details

Title: Subtitle: Multidrug resistance in fungi
Creators: Kailash Gulshan - University of Iowa
W Scott Moye-Rowley - University of Iowa
Resource Type: Journal article
Publication Details: Eukaryotic cell, Vol.6(11), pp.1933-1942
DOI: 10.1128/EC.00254-07
PMID: 17873085
PMCID: PMC2168405
NLM abbreviation: Eukaryot Cell
ISSN: 1535-9778
eISSN: 1535-9786
Publisher: American Society for Microbiology
Grant note: GM75120 / NIGMS NIH HHS R01 GM049825 / NIGMS NIH HHS GM49825 / NIGMS NIH HHS R01 GM075120 / NIGMS NIH HHS
Language: English
Date published: 11/2007
Academic Unit: Molecular Physiology and Biophysics; Internal Medicine
Record Identifier: 9984297605902771

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