Journal article
Multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii: resistance mechanisms and implications for therapy
Expert review of anti-infective therapy, Vol.8(1), pp.71-93
01/01/2010
DOI: 10.1586/eri.09.108
PMID: 20014903
Abstract
Pseudomonas aeruginosa and Acinetobacter baumannii are major nosocomial pathogens worldwide. Both are intrinsically resistant to many drugs and are able to become resistant to virtually any antimicrobial agent. An increasing prevalence of infections caused by multidrug-resistant (MDR) isolates has been reported in many countries. The resistance mechanisms of P. aeruginosa and A. baumannii include the production of -lactamases, efflux pumps, and target-site or outer membrane modifications. Resistance to multiple drugs is usually the result of the combination of different mechanisms in a single isolate or the action of a single potent resistance mechanism. There are many challenges in the treatment of MDR P. aeruginosa and A. baumannii, especially considering the absence of new antimicrobials in the drug-development pipeline. In this review, we present the major resistance mechanisms of P. aeruginosa and A. baumannii, and discuss how they can affect antimicrobial therapy, considering recent clinical, microbiological, pharmacokinetic and pharmacodynamic findings of the main drugs used to treat MDR isolates.
Details
- Title: Subtitle
- Multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii: resistance mechanisms and implications for therapy
- Creators
- Alexandre P Zavascki - Universidade Federal do Rio GrandeCecília G Carvalhaes - Universidade Federal de São PauloRenata C Picão - Universidade Federal de São PauloAna C Gales - Universidade Federal de São Paulo
- Resource Type
- Journal article
- Publication Details
- Expert review of anti-infective therapy, Vol.8(1), pp.71-93
- DOI
- 10.1586/eri.09.108
- PMID
- 20014903
- NLM abbreviation
- Expert Rev Anti Infect Ther
- ISSN
- 1478-7210
- eISSN
- 1744-8336
- Publisher
- Informa Healthcare
- Language
- English
- Date published
- 01/01/2010
- Academic Unit
- Pathology
- Record Identifier
- 9984185176102771
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