Multifaceted characterization of antibacterial resin composites: A scoping review on efficacy, properties, and in vivo performance

Reinaldo Adelino de Sales-Junior; Mariana Silva de Bessa; Francisca Jennifer Duarte de Oliveira; Bárbara Faria de Sá Barbosa; Kaiza de Sousa Santos; Michael Owen; Victor Pinheiro Feitosa; Boniek Castillo Dutra Borges

doi:10.1016/j.jdsr.2025.05.003

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Multifaceted characterization of antibacterial resin composites: A scoping review on efficacy, properties, and in vivo performance

Journal article

Open access

Peer reviewed

Multifaceted characterization of antibacterial resin composites: A scoping review on efficacy, properties, and in vivo performance

Reinaldo Adelino de Sales-Junior, Mariana Silva de Bessa, Francisca Jennifer Duarte de Oliveira, Bárbara Faria de Sá Barbosa, Kaiza de Sousa Santos, Michael Owen, Victor Pinheiro Feitosa and Boniek Castillo Dutra Borges

The Japanese dental science review, Vol.61, pp.112-137

12/01/2025

DOI: 10.1016/j.jdsr.2025.05.003

PMCID: PMC12169695

PMID: 40524950

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https://doi.org/10.1016/j.jdsr.2025.05.003View

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Abstract

This scoping review aimed to collect, analyze, synthesize, and interpret the current data concerning antibacterial resin-based composites. The study followed the recommendations of the Joanna Briggs Institute and PRISMA Extension for Scoping Reviews. The searches were conducted in the PubMed, Embase, Web of Science, and Scopus databases. Studies evaluating efficacy, physical and chemical properties, cytotoxicity, and preventive effect against recurrent caries lesions provided by antibacterial resin-based composites published in the last 5 years and without language restriction were included. Fifty-three papers were analyzed. Only in vitro, in situ, and animal studies were published. The DMAHDM (dimethylaminohexadecyl methacrylate) was the most prevalent antibacterial agent in the resin composites and showed efficacy, did not increase cytotoxicity, nor jeopardize chemical and physical properties. The most used biofilm model and the test to evaluate the antibacterial effect was Streptococcus Mutans and the Colony Forming Unit Count. Antibacterial resin-based composites have performed exceedingly well in the large number of in vitro studies evaluated. However, clinical trials assessing the prevention of recurrent caries are absent and need to be further conducted to assure that using an antibacterial resin composite is a valid way to avoid restoration replacement due to recurrent caries.

Dental Caries

Antibacterial

Resin composite

Scoping review

Details

Title: Subtitle: Multifaceted characterization of antibacterial resin composites: A scoping review on efficacy, properties, and in vivo performance
Creators: Reinaldo Adelino de Sales-Junior - Universidade Federal do Rio Grande do Norte
Mariana Silva de Bessa - Universidade Federal do Rio Grande do Norte
Francisca Jennifer Duarte de Oliveira - Universidade Federal do Rio Grande do Norte
Bárbara Faria de Sá Barbosa - Universidade Federal do Rio Grande do Norte
Kaiza de Sousa Santos - Universidade Federal do Rio Grande do Norte
Michael Owen - Department of Operative Dentistry, College of Dentistry, University of Iowa, Iowa City, IA, United States
Victor Pinheiro Feitosa - University of Iowa
Boniek Castillo Dutra Borges - Universidade Federal do Rio Grande do Norte
Resource Type: Journal article
Publication Details: The Japanese dental science review, Vol.61, pp.112-137
DOI: 10.1016/j.jdsr.2025.05.003
PMID: 40524950
PMCID: PMC12169695
NLM abbreviation: Jpn Dent Sci Rev
ISSN: 1882-7616
eISSN: 2213-6851
Publisher: ELSEVIER SCI LTD
Language: English
Date published: 12/01/2025
Academic Unit: Operative Dentistry
Record Identifier: 9984827334402771

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