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Multifaceted hemolytic uremic syndrome in pediatrics
Journal article   Open access   Peer reviewed

Multifaceted hemolytic uremic syndrome in pediatrics

Carla M Nester
Blood purification, Vol.35(1-3), pp.86-92
2013
DOI: 10.1159/000346486
PMID: 23343552
url
https://doi.org/10.1159/000346486View
Published (Version of record) Open Access

Abstract

Hemolytic uremic syndromes can have devastating consequences in childhood. The common feature of a microangiopathic hemolytic anemia and thrombocytopenia associated with varying degrees of renal injury often creates diagnostic confusion. The inability to arrive at a definitive diagnosis quickly can lead to a delay in initiating renal-preserving and sometimes life-saving treatment. Currently, both the treatment plan and the prognosis vary substantially according to the presumed diagnosis. The availability of anti-complement therapy makes differentiating the cause of the hemolytic uremic syndrome particularly critical. Therefore, it is imperative that consideration be given to each of the possible syndromes at presentation in order to facilitate correct diagnosis and development of an appropriate treatment strategy for both the acute phase and for the long-term care of the patient.
Fluid Therapy Analgesics - pharmacology Prognosis Kidney - pathology Humans Antibodies, Monoclonal - therapeutic use Long-Term Care Diarrhea - pathology Hemolytic-Uremic Syndrome - pathology Diarrhea - microbiology Blood Transfusion Hemolytic-Uremic Syndrome - microbiology Hemolytic-Uremic Syndrome - therapy Hemolytic-Uremic Syndrome - diagnosis Child Shiga-Toxigenic Escherichia coli - pathogenicity Analgesics - therapeutic use Kidney - drug effects Antibodies, Monoclonal - pharmacology Renal Replacement Therapy Delayed Diagnosis Shiga-Toxigenic Escherichia coli - drug effects Shiga-Toxigenic Escherichia coli - growth & development Diagnostic Tests, Routine Diarrhea - diagnosis Diarrhea - therapy

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