Multifunctional carbon nanospheres with magnetic and luminescent probes: probable brain theranostic agents

Piyush Chaturbedy; Snehajyoti Chatterjee; Ruthrotha B Selvi; Akshay Bhat; M K Kavitha; Vivek Tiwari; Anant B Patel; Tapas K Kundu; Tapas K Maji; M Eswaramoothy

doi:10.1039/c2tb00134a

Journal article

Multifunctional carbon nanospheres with magnetic and luminescent probes: probable brain theranostic agents

Piyush Chaturbedy, Snehajyoti Chatterjee, Ruthrotha B Selvi, Akshay Bhat, M K Kavitha, Vivek Tiwari, Anant B Patel, Tapas K Kundu, Tapas K Maji and M Eswaramoothy

Journal of materials chemistry. B, Materials for biology and medicine, Vol.1(7), pp.939-945

02/21/2013

DOI: 10.1039/c2tb00134a

PMID: 32262358

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Abstract

Multi-functional carbon nanospheres with magnetic Prussian blue nanoparticles and luminescent lanthanide ions have been prepared. The negatively charged surface of the glucose derived carbon sphere facilitates the nucleation of Prussian blue nanoparticles on its surface. The luminescent lanthanide probes were attached to the surface of the carbon sphere through a benzene tricarboxylic acid linker. These multifunctional hybrid organic-inorganic composites are superparamagnetic and show enhanced luminescent properties. Their ability to cross the blood-brain barrier (enter the brain cell nucleus with no animal toxicity) in a mouse model indicate that these nanocomposites are promising theranostic agents for the treatment of brain diseases.

Details

Title: Subtitle: Multifunctional carbon nanospheres with magnetic and luminescent probes: probable brain theranostic agents
Creators: Piyush Chaturbedy - Jawaharlal Nehru Centre for Advanced Scientific Research
Snehajyoti Chatterjee - Jawaharlal Nehru Centre for Advanced Scientific Research
Ruthrotha B Selvi - Jawaharlal Nehru Centre for Advanced Scientific Research
Akshay Bhat - Jawaharlal Nehru Centre for Advanced Scientific Research
M K Kavitha - Jawaharlal Nehru Centre for Advanced Scientific Research
Vivek Tiwari - Centre for Cellular and Molecular Biology
Anant B Patel - Centre for Cellular and Molecular Biology
Tapas K Kundu - Jawaharlal Nehru Centre for Advanced Scientific Research
Tapas K Maji - Jawaharlal Nehru Centre for Advanced Scientific Research
M Eswaramoothy - Jawaharlal Nehru Centre for Advanced Scientific Research
Resource Type: Journal article
Publication Details: Journal of materials chemistry. B, Materials for biology and medicine, Vol.1(7), pp.939-945
DOI: 10.1039/c2tb00134a
PMID: 32262358
NLM abbreviation: J Mater Chem B
ISSN: 2050-7518
eISSN: 2050-7518
Language: English
Date published: 02/21/2013
Academic Unit: Iowa Neuroscience Institute; Neuroscience and Pharmacology
Record Identifier: 9984303742402771

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