Journal article
Multilineage hemopoietic stem cell defects in Budd Chiari syndrome
Journal of hepatology, Vol.26(2), pp.293-297
1997
DOI: 10.1016/S0168-8278(97)80044-X
Abstract
Background/Aims: Erythropoietin-independent endogenous growth of erythroid colony from bone marrow cells has been shown in many patients with Budd Chiari syndrome in earlier studies. In another report, increased megakaryocyte colony growth has also been documented in this disease. However, defects in granulocyte-macrophage cell lines in Budd Chiari syndrome have yet to be reported in the literature.
Methods: Both
in vitro erythroid and granulocyte-macrophage colony cultures from peripheral blood mononuclear cells with and without erythropoietin or granulocyte-macrophage colony stimulating factor, respectively, were studied in 32 patients with Budd Chiari syndrome, along with 20 normal healthy controls and ten patient controls with portal hypertension (five patients each with noncirrhotic portal fibrosis and liver cirrhosis). In 18 patients the occlusion was only in the inferior vena cava, in five patients only in hepatic veins, and in nine patients both inferior vena cava and hepatic veins were blocked.
Result: Endogenous erythroid or granulocyte-macrophage colony growth was not observed in any of the normal healthy controls or in patient controls with portal hypertension. However, 22 of the 32 (68.8%) patients showed endogenous erythroid colony growth. Moreover, four of them also showed endogenous growth of granulocyte-macrophage colony, not previously reported in Budd Chiari syndrome.
Conclusion: It may be inferred that stem cell defects affecting all three hemopoietic cell lines (erythroid, megakaryocyte and granulocyte-macrophage) occur in Budd Chiari syndrome, which may be the primary defect responsible for the pro-thrombotic state causing venous thrombosis in them.
Details
- Title: Subtitle
- Multilineage hemopoietic stem cell defects in Budd Chiari syndrome
- Creators
- Sanjana Dayal - University of Iowa, Internal MedicineHara Prasad PatiGirish Kumar Pande - Gastro-Intestinal Surgery, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, IndiaMahesh Prakash Sharma - Gastroenterology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, IndiaAnil Kumar Saraya
- Resource Type
- Journal article
- Publication Details
- Journal of hepatology, Vol.26(2), pp.293-297
- Publisher
- Elsevier B.V
- DOI
- 10.1016/S0168-8278(97)80044-X
- ISSN
- 0168-8278
- eISSN
- 1600-0641
- Language
- English
- Date published
- 1997
- Academic Unit
- Internal Medicine; Hematology, Oncology, and Blood & Marrow Transplantation; Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984065494102771
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