Journal article
Multimodal imaging of repetition priming: Using fMRI, MEG, and intracranial EEG to reveal spatiotemporal profiles of word processing
NeuroImage (Orlando, Fla.), Vol.53(2), pp.707-717
2010
DOI: 10.1016/j.neuroimage.2010.06.069
PMCID: PMC2930128
PMID: 20620212
Abstract
Repetition priming is a core feature of memory processing whose anatomical correlates remain poorly understood. In this study, we use advanced multimodal imaging (functional magnetic resonance imaging (fMRI) and magnetoencephalography; MEG) to investigate the spatiotemporal profile of repetition priming. We use intracranial electroencephalography (iEEG) to validate our fMRI/MEG measurements. Twelve controls completed a semantic judgment task with fMRI and MEG that included words presented once (new, ‘N’) and words that repeated (old, ‘O’). Six patients with epilepsy completed the same task during iEEG recordings. Blood-oxygen level dependent (BOLD) responses for N vs. O words were examined across the cortical surface and within regions of interest. MEG waveforms for N vs. O words were estimated using a noise-normalized minimum norm solution, and used to interpret the timecourse of fMRI. Spatial concordance was observed between fMRI and MEG repetition effects from 350 to 450
ms within bilateral occipitotemporal and medial temporal, left prefrontal, and left posterior temporal cortex. Additionally, MEG revealed widespread sources within left temporoparietal regions, whereas fMRI revealed bilateral reductions in occipitotemporal and left superior frontal, and increases in inferior parietal, precuneus, and dorsolateral prefrontal activity. BOLD suppression in left posterior temporal, left inferior prefrontal, and right occipitotemporal cortex correlated with MEG repetition-related reductions. IEEG responses from all three regions supported the timecourse of MEG and localization of fMRI. Furthermore, iEEG decreases to repeated words were associated with decreased gamma power in several regions, providing evidence that gamma oscillations are tightly coupled to cognitive phenomena and reflect regional activations seen in the BOLD signal.
► MEG, FMRI, and iEEG recordings can unveil the timing, location, and spectral features of repetition priming effects. ► BOLD suppression in left perisylvian regions shows strong spatial concordance to MEG N400 reductions. ► Gamma oscillations seen in iEEG recordings reflect regional activations in the BOLD signal.
Details
- Title: Subtitle
- Multimodal imaging of repetition priming: Using fMRI, MEG, and intracranial EEG to reveal spatiotemporal profiles of word processing
- Creators
- Carrie R McDonald - Department of Psychiatry, University of California, San Diego, CA, USAThomas Thesen - Multimodal Imaging Laboratory, University of California, San Diego, CA, USAChad Carlson - Comprehensive Epilepsy Center, Department of Neurology, New York University, New York, NY, USAMark Blumberg - Comprehensive Epilepsy Center, Department of Neurology, New York University, New York, NY, USAHolly M Girard - Multimodal Imaging Laboratory, University of California, San Diego, CA, USAAmy Trongnetrpunya - Comprehensive Epilepsy Center, Department of Neurology, New York University, New York, NY, USAJason S Sherfey - Multimodal Imaging Laboratory, University of California, San Diego, CA, USAOrrin Devinsky - Comprehensive Epilepsy Center, Department of Neurology, New York University, New York, NY, USARubin Kuzniecky - Comprehensive Epilepsy Center, Department of Neurology, New York University, New York, NY, USAWerner K Dolye - Department of Neurosurgery, New York University, New York, NY, USASydney S Cash - Multimodal Imaging Laboratory, University of California, San Diego, CA, USAMatthew K Leonard - Multimodal Imaging Laboratory, University of California, San Diego, CA, USADonald J Hagler - Multimodal Imaging Laboratory, University of California, San Diego, CA, USAAnders M Dale - Multimodal Imaging Laboratory, University of California, San Diego, CA, USAEric Halgren - Multimodal Imaging Laboratory, University of California, San Diego, CA, USA
- Resource Type
- Journal article
- Publication Details
- NeuroImage (Orlando, Fla.), Vol.53(2), pp.707-717
- DOI
- 10.1016/j.neuroimage.2010.06.069
- PMID
- 20620212
- PMCID
- PMC2930128
- NLM abbreviation
- Neuroimage
- ISSN
- 1053-8119
- eISSN
- 1095-9572
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2010
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute; Biology
- Record Identifier
- 9984070615102771
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