Journal article
Multiomic signals associated with maternal epidemiological factors contributing to preterm birth in low- and middle-income countries
Science advances, Vol.9(21), p.eade7692
05/26/2023
DOI: 10.1126/sciadv.ade7692
PMCID: PMC10208584
PMID: 37224249
Abstract
Preterm birth (PTB) is the leading cause of death in children under five, yet comprehensive studies are hindered by its multiple complex etiologies. Epidemiological associations between PTB and maternal characteristics have been previously described. This work used multiomic profiling and multivariate modeling to investigate the biological signatures of these characteristics. Maternal covariates were collected during pregnancy from 13,841 pregnant women across five sites. Plasma samples from 231 participants were analyzed to generate proteomic, metabolomic, and lipidomic datasets. Machine learning models showed robust performance for the prediction of PTB (AUROC = 0.70), time-to-delivery (
= 0.65), maternal age (
= 0.59), gravidity (
= 0.56), and BMI (
= 0.81). Time-to-delivery biological correlates included fetal-associated proteins (e.g., ALPP, AFP, and PGF) and immune proteins (e.g., PD-L1, CCL28, and LIFR). Maternal age negatively correlated with collagen COL9A1, gravidity with endothelial NOS and inflammatory chemokine CXCL13, and BMI with leptin and structural protein FABP4. These results provide an integrated view of epidemiological factors associated with PTB and identify biological signatures of clinical covariates affecting this disease.
Details
- Title: Subtitle
- Multiomic signals associated with maternal epidemiological factors contributing to preterm birth in low- and middle-income countries
- Creators
- Camilo A Espinosa - Stanford University School of MedicineWaqasuddin Khan - Department of Pediatrics and Child Health, Faculty of Health Sciences, Medical College, The Aga Khan University, Karachi, PakistanRasheda Khanam - Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USASayan Das - Centre for Public Health Kinetics, New Delhi, Delhi, IndiaJavairia Khalid - Department of Pediatrics and Child Health, Faculty of Health Sciences, Medical College, The Aga Khan University, Karachi, PakistanJesmin Pervin - International Centre for Diarrhoeal Disease ResearchMargaret P Kasaro - University of North Carolina School of MedicineKévin Contrepois - Stanford University School of MedicineAlan L Chang - Stanford University School of MedicineThanaphong Phongpreecha - Stanford University School of MedicineBasil Michael - Stanford University School of MedicineMathew Ellenberger - Stanford University School of MedicineUsma Mehmood - Department of Pediatrics and Child Health, Faculty of Health Sciences, Medical College, The Aga Khan University, Karachi, PakistanAneeta Hotwani - Department of Pediatrics and Child Health, Faculty of Health Sciences, Medical College, The Aga Khan University, Karachi, PakistanAmbreen Nizar - Department of Pediatrics and Child Health, Faculty of Health Sciences, Medical College, The Aga Khan University, Karachi, PakistanFurqan Kabir - Department of Pediatrics and Child Health, Faculty of Health Sciences, Medical College, The Aga Khan University, Karachi, PakistanRonald J Wong - Stanford University School of MedicineMartin Becker - Stanford University School of MedicineEloise Berson - Stanford University School of MedicineAnthony Culos - Columbia UniversityDavide De Francesco - Stanford University School of MedicineSamson Mataraso - Stanford University School of MedicineNeal Ravindra - Stanford University School of MedicineMelan Thuraiappah - Stanford University School of MedicineMaria Xenochristou - Stanford University School of MedicineIna A Stelzer - Stanford University School of MedicineIvana Marić - Stanford University School of MedicineArup Dutta - Centre for Public Health Kinetics, New Delhi, Delhi, IndiaRubhana Raqib - International Centre for Diarrhoeal Disease ResearchSalahuddin Ahmed - Projahnmo Research Foundation, Dhaka, BangladeshSayedur Rahman - Projahnmo Research Foundation, Dhaka, BangladeshA S M Tarik Hasan - Projahnmo Research Foundation, Dhaka, BangladeshSaid M Ali - Public Health Laboratory Ivo de CarneriMohamed H Juma - Public Health Laboratory Ivo de CarneriMonjur Rahman - International Centre for Diarrhoeal Disease ResearchShaki Aktar - International Centre for Diarrhoeal Disease ResearchSaikat Deb - Public Health Laboratory Ivo de CarneriJoan T Price - University of ZambiaPaul H Wise - Stanford University School of MedicineVirginia D Winn - Stanford University School of MedicineMaurice L Druzin - Stanford University School of MedicineRonald S Gibbs - Stanford University School of MedicineGary L Darmstadt - Stanford University School of MedicineJeffrey C Murray - University of IowaJeffrey S A Stringer - University of North Carolina School of MedicineBrice Gaudilliere - Stanford University School of MedicineMichael P Snyder - Stanford University School of MedicineMartin S Angst - Stanford University School of MedicineAnisur Rahman - International Centre for Diarrhoeal Disease ResearchAbdullah H Baqui - Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USAFyezah Jehan - Department of Pediatrics and Child Health, Faculty of Health Sciences, Medical College, The Aga Khan University, Karachi, PakistanMuhammad Imran Nisar - Department of Pediatrics and Child Health, Faculty of Health Sciences, Medical College, The Aga Khan University, Karachi, PakistanBellington Vwalika - University of ZambiaSunil Sazawal - Johns Hopkins UniversityGary M Shaw - Stanford University School of MedicineDavid K Stevenson - Stanford University School of MedicineNima Aghaeepour - Stanford University School of Medicine
- Resource Type
- Journal article
- Publication Details
- Science advances, Vol.9(21), p.eade7692
- DOI
- 10.1126/sciadv.ade7692
- PMID
- 37224249
- PMCID
- PMC10208584
- NLM abbreviation
- Sci Adv
- ISSN
- 2375-2548
- eISSN
- 2375-2548
- Grant note
- R35 GM138353 / NIGMS NIH HHS
- Language
- English
- Date published
- 05/26/2023
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9985035880502771
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