Journal article
Multiparametric magnetic resonance imaging and positron emission tomography findings in neurodegenerative diseases: Current status and future directions
The neuroradiology journal, Vol.34(4), pp.263-288
08/01/2021
DOI: 10.1177/1971400921998968
PMCID: PMC8447818
PMID: 33666110
Abstract
Neurodegenerative diseases (NDDs) are characterized by progressive neuronal loss, leading to dementia and movement disorders. NDDs broadly include Alzheimer's disease, frontotemporal lobar degeneration, parkinsonian syndromes, and prion diseases. There is an ever-increasing prevalence of mild cognitive impairment and dementia, with an accompanying immense economic impact, prompting efforts aimed at early identification and effective interventions. Neuroimaging is an essential tool for the early diagnosis of NDDs in both clinical and research settings. Structural, functional, and metabolic imaging modalities, including magnetic resonance imaging (MRI) and positron emission tomography (PET), are widely available. They show encouraging results for diagnosis, monitoring, and treatment response evaluation. The current review focuses on the complementary role of various imaging modalities in relation to NDDs, the qualitative and quantitative utility of newer MRI techniques, novel radiopharmaceuticals, and integrated PET/MRI in the setting of NDDs.
Details
- Title: Subtitle
- Multiparametric magnetic resonance imaging and positron emission tomography findings in neurodegenerative diseases: Current status and future directions
- Creators
- Neetu Soni - University of IowaManish Ora - Department of Nuclear Medicine, SGPGIMS, India.Girish Bathla - University of IowaChandana Nagaraj - National Institute of Mental Health and NeurosciencesLaura L. Boles - Univ Iowa Hosp & Clin, PET Imaging Ctr, Iowa City, IA 52242 USAMichael M. Graham - University of Iowa Hospitals and ClinicsJitender Saini - National Institute of Mental Health and NeurosciencesYusuf Menda - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- The neuroradiology journal, Vol.34(4), pp.263-288
- Publisher
- Sage
- DOI
- 10.1177/1971400921998968
- PMID
- 33666110
- PMCID
- PMC8447818
- ISSN
- 1971-4009
- eISSN
- 2385-1996
- Number of pages
- 26
- Language
- English
- Date published
- 08/01/2021
- Academic Unit
- Radiology; Radiation Oncology
- Record Identifier
- 9984313083702771
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