Journal article
Multiple-Domain Predictors of Problematic Alcohol Use in Young Adulthood
Journal of studies on alcohol and drugs, Vol.69(5), pp.649-659
09/2008
DOI: 10.15288/jsad.2008.69.649
PMCID: PMC2575389
PMID: 18781239
Abstract
Objective: The goal of this study was to identify predictors of problematic young adult alcohol use. Method: The sample consisted of 141 subjects (81 females) participating in a national study of genetic risk factors for alcoholism. All subjects were evaluated first as children or adolescents, then approximately 5 years later as young adults. Outcome consisted of the number of alcohol symptoms (0-10) endorsed at this second time point. Predictors of outcome were drawn from five domains representing: (1) Demographic Characteristics, (2) Child/Adolescent Problematic Alcohol Use, (3) Biological Risk, (4) Externalizing Behaviors, and (5) Family Environment. A two-stage analytic strategy was used in which (1) separate multiple regression analyses were conducted within each of the five domains and (2) statistically significant predictors of problematic alcohol use from each domain were combined into one regression model to determine which remained significant. Results: In the final model, 31% of the variance in the number of alcohol symptoms in young adulthood was predicted by a high number of alcohol symptoms in childhood and adolescence, low initial sensitivity to alcohol, and a negative child/adolescent relationship with the father. Conclusions: These results demonstrated that GABRA2—originally associated with a diagnosis of alcohol dependence in adults—also predicted the onset of symptoms among subjects in their 20s, confirmed specific hypotheses about three other predictors in the final model, and suggested the utility of incorporating biological and nonbiological predictors to optimally predict young adult alcohol problems.
Details
- Title: Subtitle
- Multiple-Domain Predictors of Problematic Alcohol Use in Young Adulthood
- Creators
- John R Kramer - Department of Psychiatry, Medical Education Building, University of Iowa School of Medicine, 500 Newton Road, Iowa City, Iowa 52242-1000Grace Chan - Department of Psychiatry, Medical Education Building, University of Iowa School of Medicine, 500 Newton Road, Iowa City, Iowa 52242-1000Danielle M Dick - Department of Psychiatry, Medical Education Building, University of Iowa School of Medicine, 500 Newton Road, Iowa City, Iowa 52242-1000Samuel Kuperman - Department of Psychiatry, Medical Education Building, University of Iowa School of Medicine, 500 Newton Road, Iowa City, Iowa 52242-1000Kathleen K Bucholz - Department of Psychiatry, Medical Education Building, University of Iowa School of Medicine, 500 Newton Road, Iowa City, Iowa 52242-1000Howard J Edenberg - Department of Psychiatry, Medical Education Building, University of Iowa School of Medicine, 500 Newton Road, Iowa City, Iowa 52242-1000Linnea A Polgreen - Department of Psychiatry, Medical Education Building, University of Iowa School of Medicine, 500 Newton Road, Iowa City, Iowa 52242-1000Victor M Hesselbrock - Department of Psychiatry, Medical Education Building, University of Iowa School of Medicine, 500 Newton Road, Iowa City, Iowa 52242-1000Marc A Schuckit - Department of Psychiatry, Medical Education Building, University of Iowa School of Medicine, 500 Newton Road, Iowa City, Iowa 52242-1000John I Nurnberger - Department of Psychiatry, Medical Education Building, University of Iowa School of Medicine, 500 Newton Road, Iowa City, Iowa 52242-1000Ellen S Kapp - Department of Psychiatry, Medical Education Building, University of Iowa School of Medicine, 500 Newton Road, Iowa City, Iowa 52242-1000Bernice Porjesz - Department of Psychiatry, Medical Education Building, University of Iowa School of Medicine, 500 Newton Road, Iowa City, Iowa 52242-1000Laura J Bierut - Department of Psychiatry, Medical Education Building, University of Iowa School of Medicine, 500 Newton Road, Iowa City, Iowa 52242-1000
- Resource Type
- Journal article
- Publication Details
- Journal of studies on alcohol and drugs, Vol.69(5), pp.649-659
- DOI
- 10.15288/jsad.2008.69.649
- PMID
- 18781239
- PMCID
- PMC2575389
- NLM abbreviation
- J Stud Alcohol Drugs
- ISSN
- 1937-1888
- eISSN
- 1938-4114
- Publisher
- Rutgers University
- Language
- English
- Date published
- 09/2008
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics; Economics; Pharmacy Practice and Science
- Record Identifier
- 9984003442702771
Metrics
13 Record Views