Journal article
Multiple Linear Regression Modeling of Furosemide Renal Clearance and Urinary Excretion Rate
Journal of pharmaceutical sciences, Vol.80(11), pp.1084-1091
11/1991
DOI: 10.1002/jps.2600801118
PMID: 1815062
Abstract
Multiple linear regression techniques were utilized to determine models for the renal clearance and urinary excretion rate of furosemide. Models for the renal clearance were formulated based on data collected from the literature. The best model predicted that the weight-normalized renal clearance was a function of the weight-normalized creatinine clearance, with coefficient values dependent on the presence or absence of heart, liver, and/or kidney failure. The predictive performance of this model was evaluated using a separate verification data set, and, prospectively, for a group of cardiac patients. The urinary excretion rate of furosemide is the primary determinate of response. Models for the furosemide excretion rate were formulated from data collected prospectively from a group of patients with cardiac disease. The best model predicted that the dose-normalized morning urinary excretion rate was a function of the blood urea nitrogen concentration (BUN), with modifications for the presence of liver failure and/or decompensated heart failure. The oral dosage required to produce a clinically optimal furosemide excretion rate in cardiac patients without liver disease was dose (mg) = 42.1/(0.925 – 0.0151 BUN).
Details
- Title: Subtitle
- Multiple Linear Regression Modeling of Furosemide Renal Clearance and Urinary Excretion Rate
- Creators
- Laura L Boles Ponto - Department of Radiology, Division of Nuclear Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242Ronald D Schoenwald - Division of Pharmaceutics, College of Pharmacy, University of Iowa, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of pharmaceutical sciences, Vol.80(11), pp.1084-1091
- DOI
- 10.1002/jps.2600801118
- PMID
- 1815062
- NLM abbreviation
- J Pharm Sci
- ISSN
- 0022-3549
- eISSN
- 1520-6017
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 11/1991
- Academic Unit
- Radiology; Pharmacy; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984051977802771
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