Journal article
Multiple Luteinizing Hormone/Chorionic Gonadotropin Receptor Messenger Ribonucleic Acid Transcripts
Endocrinology (Philadelphia), Vol.129(1), pp.133-138
07/1991
DOI: 10.1210/endo-129-1-133
PMID: 2055178
Abstract
It has previously been shown that multiple messenger RNA (mRNA) species can be identified in gonadal tissues by probes specific for the LH/CG receptor. Here we show that the sizes and relative abundancies of gonadal LH/CG receptor transcripts are quite variable between such closely related species as rat and mouse. These patterns of LH/CG receptor mRNAs are yet different from that observed in human embryonic kidney 293 cells that have been transfected with a cDNA encoding for the rat luteal LH/CG receptor. In spite of the diversity in the number and sizes of LH/CG receptor mRNA transcripts, however, our data also show that the size of the cell surface receptor expressed in these three cells/tissues is identical. We further show that the most abundant LH/CG receptor mRNA present in MA-10 cells, a clonal strain of cultured Leydig tumor cells, is a 1.2 kilobase transcript which encodes for a truncated version of the LH/CG receptor corresponding to the extracellular hormone-binding domain. It does not appear, however, that this transcript is translated into a functional protein.
Details
- Title: Subtitle
- Multiple Luteinizing Hormone/Chorionic Gonadotropin Receptor Messenger Ribonucleic Acid Transcripts
- Creators
- HAIYUN WANGMARIO ASCOLIDEBORAH L SEGALOFF
- Resource Type
- Journal article
- Publication Details
- Endocrinology (Philadelphia), Vol.129(1), pp.133-138
- DOI
- 10.1210/endo-129-1-133
- PMID
- 2055178
- ISSN
- 0013-7227
- eISSN
- 1945-7170
- Language
- English
- Date published
- 07/1991
- Academic Unit
- Molecular Physiology and Biophysics; Obstetrics and Gynecology; Neuroscience and Pharmacology
- Record Identifier
- 9984083216002771
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