Multiple Nonspecific Sites of Joint Pain Outside the Knees Develop in Persons With Knee Pain

David T Felson; Jingbo Niu; Emily K Quinn; Tuhina Neogi; Cara Lewis; Cora E Lewis; Laura Frey Law; Chuck McCulloch; Michael Nevitt; Michael LaValley

doi:10.1002/art.39848

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Multiple Nonspecific Sites of Joint Pain Outside the Knees Develop in Persons With Knee Pain

Journal article

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Multiple Nonspecific Sites of Joint Pain Outside the Knees Develop in Persons With Knee Pain

David T Felson, Jingbo Niu, Emily K Quinn, Tuhina Neogi, Cara Lewis, Cora E Lewis, Laura Frey Law, Chuck McCulloch, Michael Nevitt and Michael LaValley

Arthritis & rheumatology (Hoboken, N.J.), Vol.69(2), pp.335-342

02/2017

DOI: 10.1002/art.39848

PMCID: PMC5292971

PMID: 27589036

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Abstract

Objective Many persons with knee pain have joint pain outside the knee, but despite the impact and high frequency of this pain, its distribution and causes have not been studied. We undertook this study to test the hypothesis of those studying gait abnormalities who have suggested that knee pain causes pain in adjacent joints but that pain adaptation strategies are highly individualized. Methods We studied persons ages 50–79 years with or at high risk of knee osteoarthritis who were recruited from 2 community‐based cohorts, the Multicenter Osteoarthritis Study and the Osteoarthritis Initiative, and we followed them up for 5–7 years. We excluded those with knee pain at baseline and compared those who had developed knee pain at the first follow‐up examination (the index visit) with those who had not. We examined pain on most days at joint regions outside the knee in examinations after the index visit. Logistic regression analyses examined the risk of joint‐specific pain adjusted for age, sex, body mass index, and symptoms of depression, and we performed sensitivity analyses excluding those with widespread pain. Results In the combined cohorts, 693 persons had knee pain at the index visit and 2,793 did not. A total of 79.6% of those with bilateral knee pain and 63.8% of those with unilateral knee pain had pain during follow‐up in a joint region outside the knee, compared with 49.9% of those without knee pain. There was an increased risk of pain at most extremity joint sites, without a predilection for specific sites. Results were unchanged when those with widespread pain were excluded. Conclusion Persons with chronic knee pain are at increased risk of pain in multiple joints in no specific pattern.

Details

Title: Subtitle: Multiple Nonspecific Sites of Joint Pain Outside the Knees Develop in Persons With Knee Pain
Creators: David T Felson - Boston University School of Medicine, Boston, Massachusetts, and University of Manchester and Central Manchester NHS Foundation Trust
Jingbo Niu - Boston University School of Medicine
Emily K Quinn - Boston University School of Public Health
Tuhina Neogi - Boston University School of Medicine
Cara Lewis - Boston University School of Medicine
Cora E Lewis - University of Alabama School of Medicine
Laura Frey Law - University of Iowa
Chuck McCulloch - University of California
Michael Nevitt - University of California
Michael LaValley - Boston University School of Public Health
Resource Type: Journal article
Publication Details: Arthritis & rheumatology (Hoboken, N.J.), Vol.69(2), pp.335-342
DOI: 10.1002/art.39848
PMID: 27589036
PMCID: PMC5292971
NLM abbreviation: Arthritis Rheumatol
ISSN: 2326-5191
eISSN: 2326-5205
Number of pages: 8
Grant note: NIHR (Musculoskeletal Biomedical Research Unit) NIH (AR‐47785) National Institute on Aging (U01‐AG‐18820, U01‐AG‐18832, U01‐AG‐18947, and U01‐AG‐19069)
Language: English
Date published: 02/2017
Academic Unit: Nursing; Physical Therapy and Rehabilitation Science
Record Identifier: 9984047646202771

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