Journal article
Multiple Roles for Src in a PDGF-Stimulated Cell
Experimental cell research, Vol.253(1), pp.271-279
11/25/1999
DOI: 10.1006/excr.1999.4669
PMID: 10579928
Abstract
The observation that platelet-derived growth factor (PDGF) increases the catalytic activity of Src family members (Src) suggests that they contribute to PDGF-dependent responses. The role of Src in PDGF-dependent cell cycle progression, phosphorylation of proteins, and chemotaxis has been tested by investigators using a variety of cell types and approaches, and it appears that the contribution of Src is highly variable. This idea is perhaps best illustrated by the finding that Src plays radically different roles downstream of the PDGF α- and β-receptor subunits. Hence, Src is a versatile signal relay enzyme, whose contribution to a signaling cascade depends on variables such as the nature of the receptor via which the cell is activated, as well as the cell type itself.
Details
- Title: Subtitle
- Multiple Roles for Src in a PDGF-Stimulated Cell
- Creators
- Kris A DeMali - Schepens Eye Research Institute, Harvard Medical School, 20 Staniford Street, Boston, Massachusetts, 02114Stephen L Godwin - Department of Pharmacology, University of Colorado Health Sciences Center, 4200 E. Ninth Avenue, Denver, Colorado, 80262Stephen P Soltoff - Department of Pharmacology, University of Colorado Health Sciences Center, 4200 E. Ninth Avenue, Denver, Colorado, 80262Andrius Kazlauskas - Schepens Eye Research Institute, Harvard Medical School, 20 Staniford Street, Boston, Massachusetts, 02114
- Resource Type
- Journal article
- Publication Details
- Experimental cell research, Vol.253(1), pp.271-279
- Publisher
- Elsevier Inc
- DOI
- 10.1006/excr.1999.4669
- PMID
- 10579928
- ISSN
- 0014-4827
- eISSN
- 1090-2422
- Language
- English
- Date published
- 11/25/1999
- Academic Unit
- Dermatology; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology
- Record Identifier
- 9984025297402771
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