Multiple cutaneous lymphoproliferative disorders showing a retained tumor clone by T-cell receptor gene rearrangement analysis: a case series of four patients and review of the literature

Anne M Stowman; Ling-Lun Hsia; William A Kanner; Mani S Mahadevan; Grant C Bullock; James W Patterson

doi:10.1111/ijd.12847

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Multiple cutaneous lymphoproliferative disorders showing a retained tumor clone by T-cell receptor gene rearrangement analysis: a case series of four patients and review of the literature

Journal article

Peer reviewed

Multiple cutaneous lymphoproliferative disorders showing a retained tumor clone by T-cell receptor gene rearrangement analysis: a case series of four patients and review of the literature

Anne M Stowman, Ling-Lun Hsia, William A Kanner, Mani S Mahadevan, Grant C Bullock and James W Patterson

International journal of dermatology, Vol.55(2), pp.e62-e71

02/2016

DOI: 10.1111/ijd.12847

PMID: 26266670

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Abstract

Mycosis fungoides (MF) is the most common primary cutaneous T-cell lymphoma (CTCL), followed by CD30+ lymphoproliferative disorders, including lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large cell lymphoma (pcALCL). The objective was to report on a series of patients with different types of CTCL at different times in their clinical course, with a focus on clonality studies. Four patients with multiple diagnoses of CTCLs were identified. The clinical information, treatment interventions, and histopathology were reviewed. T-cell receptor (TCR) gene rearrangement studies were performed on all available specimens. The four patients carried diagnoses of: (1) pcALCL and MF; (2) pcALCL, LyP, and pcALCL; (3) LyP, MF, and pcALCL; (4) LyP, pcALCL, and MF; each with characteristic presentation and histopathologic findings. The results of the TCR polymerase chain reaction showed that all tumors expressed and retained a TCR clone(s) as follows: (1) biallelic clone; (2) single clone; (3) biallelic clone with additional clone; and (4) single clone, respectively. We report a series of four cases of individual patients with coexisting diagnoses of some combination of MF, LyP, and pcALCL, whose lesions presented in nontraditional sequence and demonstrated a retained clone by gene rearrangement analysis.

Aged, 80 and over

Alleles

Female

Gene Rearrangement

Genes, T-Cell Receptor

Humans

Ki-1 Antigen - analysis

Lymphoma, Primary Cutaneous Anaplastic Large Cell - chemistry

Lymphoma, Primary Cutaneous Anaplastic Large Cell - genetics

Lymphoma, Primary Cutaneous Anaplastic Large Cell - pathology

Lymphomatoid Papulosis - genetics

Lymphomatoid Papulosis - metabolism

Lymphomatoid Papulosis - pathology

Male

Middle Aged

Mycosis Fungoides - chemistry

Mycosis Fungoides - genetics

Mycosis Fungoides - pathology

Neoplasms, Second Primary - chemistry

Neoplasms, Second Primary - genetics

Neoplasms, Second Primary - pathology

Skin Neoplasms - chemistry

Skin Neoplasms - genetics

Skin Neoplasms - pathology

Young Adult

Details

Title: Subtitle: Multiple cutaneous lymphoproliferative disorders showing a retained tumor clone by T-cell receptor gene rearrangement analysis: a case series of four patients and review of the literature
Creators: Anne M Stowman - University of Virginia Health System
Ling-Lun Hsia - East Carolina University
William A Kanner - University of South Carolina
Mani S Mahadevan - University of Virginia Health System
Grant C Bullock - University of Pittsburgh
James W Patterson - University of Virginia Health System
Resource Type: Journal article
Publication Details: International journal of dermatology, Vol.55(2), pp.e62-e71
DOI: 10.1111/ijd.12847
PMID: 26266670
ISSN: 0011-9059
eISSN: 1365-4632
Language: English
Date published: 02/2016
Academic Unit: Pathology
Record Identifier: 9984697643302771

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