Journal article
Multiple forebrain systems converge on motor neurons innervating the thyroarytenoid muscle
Neuroscience, Vol.162(2), pp.501-524
08/18/2009
DOI: 10.1016/j.neuroscience.2009.05.005
PMCID: PMC2752708
PMID: 19426785
Abstract
The present study investigated the central connections of motor neurons innervating the thyroarytenoid laryngeal muscle that is active in swallowing, respiration and vocalization. In both intact and sympathectomized rats, the pseudorabies virus (PRV) was inoculated into the muscle. After initial infection of laryngomotor neurons in the ipsilateral loose division of the nucleus ambiguous (NA) by 3 days post-inoculation., PRV spread to the ipsilateral compact portion of the NA, the central and intermediate divisions of the nucleus tractus solitarii (NTS), the Botzinger complex, and the parvocellular reticular formation by 4 days. Infection was subsequently expanded to include the ipsilateral granular and dysgranular parietal insular cortex, the ipsilateral medial division of the central nucleus of the amygdala, the lateral, paraventricular, ventrolateral and medial preoptic nuclei of the hypothalamus (generally bilaterally), the lateral periaqueductal gray, the A7 and oral and caudal pontine nuclei. At the latest time points sampled post-inoculation (5 days), infected neurons were identified in the ipsilateral agranular insular cortex, the caudal parietal insular cortex, the anterior cingulate cortex, and the contralateral motor cortex. In the amygdala, infection had spread to the lateral central nucleus and the parvocellular portion of the basolateral nucleus. Hypothalamic infection was largely characterized by an increase in the number of infected cells in earlier infected regions though the posterior, dorsomedial, tuberomammillary and mammillary nuclei contained infected cells. Comparison with previous connectional data suggest PRV followed three interconnected systems originating in the forebrain; a bilateral system including the ventral anterior cingulate cortex, periaqueductal gray and ventral respiratory group; an ipsilateral system involving the parietal insular cortex, central nucleus of the amygdala and parvicellular reticular formation, and a minor contralateral system originating in motor cortex. Hypothalamic innervation involved several functionally specific nuclei. Overall, the data imply complex central nervous system control over the multi-functional thyroarytenoid muscle.[297 words]
Details
- Title: Subtitle
- Multiple forebrain systems converge on motor neurons innervating the thyroarytenoid muscle
- Creators
- Douglas J Van Daele - Department of Otolaryngology-Head and Neck Surgery, University of IowaMartin D Cassell - Department of Anatomy and Cell Biology, University of Iowa
- Resource Type
- Journal article
- Publication Details
- Neuroscience, Vol.162(2), pp.501-524
- DOI
- 10.1016/j.neuroscience.2009.05.005
- PMID
- 19426785
- PMCID
- PMC2752708
- NLM abbreviation
- Neuroscience
- ISSN
- 0306-4522
- eISSN
- 1873-7544
- Language
- English
- Date published
- 08/18/2009
- Academic Unit
- Anatomy and Cell Biology; Radiation Oncology; Medicine Administration; Otolaryngology
- Record Identifier
- 9984006338302771
Metrics
31 Record Views