Journal article
Multiple sclerosis patients exhibit oral dysbiosis with decreased early colonizers and lower hypotaurine level
NPJ biofilms and microbiomes, Vol.11(1), p.199
10/20/2025
DOI: 10.1038/s41522-025-00787-7
PMCID: PMC12537959
PMID: 41115930
Abstract
Although gut microbiome dysbiosis is implicated in the pathobiology of multiple sclerosis (MS), the role of the oral microbiome (OM), the second largest microbiome, remains poorly understood. Additionally, while the salivary metabolome has been linked to other neurodegenerative diseases; its role in people with Relapsing-Remitting MS (pwRRMS), the most prevalent form of MS, is unknown. Combining shotgun metagenomics with untargeted metabolomics, we identified a reduced abundance of several early colonizing species including Streptococcus and Actinomyces in pwRRMS and an enrichment of bacteria with pathogenic potential including Fusobacterium nucleatum, Porphyromonas gingivalis, and several Prevotella species. pwRRMS had an altered metabolite profile including a decreased hypotaurine compared to healthy controls. Thus we report altered oral microbiome and metabolome in pwRRMS which might contribute to MS pathobiology. These findings offer potential microbiome-metabolome based diagnostic biomarkers for MS and pave the way for novel therapeutic interventions to improve disease management and patient outcomes.
Details
- Title: Subtitle
- Multiple sclerosis patients exhibit oral dysbiosis with decreased early colonizers and lower hypotaurine level
- Creators
- Rachel L. Fitzjerrells - University of IowaLeeann Aguilar Meza - Holden Comprehensive Cancer Center, University of IowaMeeta Yadav - University of IowaHeena Olalde - University of IowaJemmie Hoang - University of IowaMishelle Paullus - University of IowaCatherine Cherwin - University of IowaTracey A. Cho - University of IowaGrant Brown - University of Iowa, BiostatisticsSukirth M. Ganesan - University of IowaAshutosh K. Mangalam - Iowa City VA Health Care System
- Resource Type
- Journal article
- Publication Details
- NPJ biofilms and microbiomes, Vol.11(1), p.199
- DOI
- 10.1038/s41522-025-00787-7
- PMID
- 41115930
- PMCID
- PMC12537959
- eISSN
- 2055-5008
- Publisher
- Nature Publishing Group UK
- Grant note
- 1P20NR018081-01 / National Institute of Nursing Research (https://doi.org/10.13039/100000056) F31DE033564; T90DE023520; R03DE030527 / National Institute of Dental and Craniofacial Research (https://doi.org/10.13039/100000072) 1RO1AI137075 / National Institute of Allergy and Infectious Diseases (https://doi.org/10.13039/100000060) Gift from P. Heppelmann and M. Wacek 1I01CX002212 / U.S. Department of Veterans Affairs (https://doi.org/10.13039/100000738) Carver Trust Pilot Grant P30 ES005605 / National Institute of Environmental Health Sciences (https://doi.org/10.13039/100000066)
- Language
- English
- Date published
- 10/20/2025
- Academic Unit
- Neurology; Pathology; Iowa Neuroscience Institute; Biostatistics; Nursing; Medicine Administration; Periodontics
- Record Identifier
- 9985014805902771
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