Multireader sample size program for diagnostic studies: demonstration and methodology

Stephen L Hillis; Kevin M Schartz

doi:10.1117/1.JMI.5.4.045503

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Multireader sample size program for diagnostic studies: demonstration and methodology

Journal article

Open access

Peer reviewed

Multireader sample size program for diagnostic studies: demonstration and methodology

Stephen L Hillis and Kevin M Schartz

Journal of medical imaging (Bellingham, Wash.), Vol.5(4), pp.045503-045503

10/2018

DOI: 10.1117/1.JMI.5.4.045503

PMCID: PMC6265604

PMID: 30525062

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https://doi.org/10.1117/1.JMI.5.4.045503View

Published (Version of record) Open Access

Abstract

The software “Multireader sample size program for diagnostic studies,” written by Kevin Schartz and Stephen Hillis, performs sample size computations for diagnostic reader-performance studies. The program computes the sample size needed to detect a specified difference in a reader-performance measure between two imaging modalities when using the analysis methods initially proposed by Dorfman, Berbaum, and Metz, and Obuchowski and Rockette, and later unified and improved by Hillis and colleagues. A commonly used reader-performance measure is the area under the receiver-operating-characteristic curve. The program has an easy-to-use step-by-step intuitive interface that walks the user through the entry of the needed information. It can be used with several different study designs, inference procedures, hypotheses, and input and output formats. The program is functional in Windows, OS X, and Linux. The methodology underlying the software is discussed for the most common diagnostic study design, where each reader evaluates each case using each modality.

Dorfman–Berbaum–Metz

reader performance

Image Perception, Observer Performance, and Technology Assessment

Paper

Obuchowski–Rockette

diagnostic radiology

multireader multicase

sample size estimation

Details

Title: Subtitle: Multireader sample size program for diagnostic studies: demonstration and methodology
Creators: Stephen L Hillis - , Departments of Radiology and Biostatistics, Iowa City, Iowa
Kevin M Schartz - , Department of Radiology, Iowa City, Iowa
Resource Type: Journal article
Publication Details: Journal of medical imaging (Bellingham, Wash.), Vol.5(4), pp.045503-045503
Publisher: Society of Photo-Optical Instrumentation Engineers
DOI: 10.1117/1.JMI.5.4.045503
PMID: 30525062
PMCID: PMC6265604
ISSN: 2329-4302
eISSN: 2329-4310
Grant note: R01EB013667; R01EB019967 / National Institute of Biomedical Imaging and Bioengineering
Language: English
Date published: 10/2018
Academic Unit: Radiology; Biostatistics
Record Identifier: 9984051524602771

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