Multiscale AM-FM Methods for Diabetic Retinopathy Lesion Detection

C Agurto; V Murray; E Barriga; S Murillo; M Pattichis; H Davis; S Russell; M Abramoff; P Soliz

doi:10.1109/TMI.2009.2037146

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Journal article

Multiscale AM-FM Methods for Diabetic Retinopathy Lesion Detection

C Agurto, V Murray, E Barriga, S Murillo, M Pattichis, H Davis, S Russell, M Abramoff and P Soliz

IEEE Transactions on Medical Imaging, Vol.29(2), pp.502-512

02/2010

DOI: 10.1109/TMI.2009.2037146

PMCID: PMC2825390

PMID: 20129850

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https://www.ncbi.nlm.nih.gov/pmc/articles/2825390View

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Abstract

In this paper, we propose the use of multiscale amplitude-modulation-frequency-modulation (AM-FM) methods for discriminating between normal and pathological retinal images. The method presented in this paper is tested using standard images from the early treatment diabetic retinopathy study. We use 120 regions of 40 × 40 pixels containing four types of lesions commonly associated with diabetic retinopathy (DR) and two types of normal retinal regions that were manually selected by a trained analyst. The region types included microaneurysms, exudates, neovascularization on the retina, hemorrhages, normal retinal background, and normal vessels patterns. The cumulative distribution functions of the instantaneous amplitude, the instantaneous frequency magnitude, and the relative instantaneous frequency angle from multiple scales are used as texture feature vectors. We use distance metrics between the extracted feature vectors to measure interstructure similarity. Our results demonstrate a statistical differentiation of normal retinal structures and pathological lesions based on AM-FM features. We further demonstrate our AM-FM methodology by applying it to classification of retinal images from the MESSIDOR database. Overall, the proposed methodology shows significant capability for use in automatic DR screening.

Pathology

Diabetes

Retinopathy

Retina

Automatic screening

Frequency

Feature extraction

multiscale amplitude-modulation-frequency-modulation (AM-FM) methods

Lesions

Hemorrhaging

Testing

Distribution functions

diabetic retinopathy (DR)

Details

Title: Subtitle: Multiscale AM-FM Methods for Diabetic Retinopathy Lesion Detection
Creators: C Agurto - Dept. of Electr. & Comput. Eng., Univ. of New Mexico, Albuquerque, NM, USA
V Murray - Dept. of Electr. & Comput. Eng., Univ. of New Mexico, Albuquerque, NM, USA
E Barriga - VisionQuest Biomed., Albuquerque, NM, USA
S Murillo - Dept. of Electr. & Comput. Eng., Univ. of New Mexico, Albuquerque, NM, USA
M Pattichis - Dept. of Electr. & Comput. Eng., Univ. of New Mexico, Albuquerque, NM, USA
H Davis - VisionQuest Biomedical (United States)
S Russell - Dept. of Ophtalmology & Visual Sci., Univ. of Iowa Hosp. & Clinics, Iowa City, IA, USA
M Abramoff - Dept. of Ophtalmology & Visual Sci., Univ. of Iowa Hosp. & Clinics, Iowa City, IA, USA
P Soliz - VisionQuest Biomed., Albuquerque, NM, USA
Resource Type: Journal article
Publication Details: IEEE Transactions on Medical Imaging, Vol.29(2), pp.502-512
DOI: 10.1109/TMI.2009.2037146
PMID: 20129850
PMCID: PMC2825390
NLM abbreviation: IEEE Trans Med Imaging
ISSN: 0278-0062
eISSN: 1558-254X
Publisher: IEEE
Language: English
Date published: 02/2010
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Ophthalmology and Visual Sciences
Record Identifier: 9983806370002771

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