Multiscale Mechanical Simulations of Cell Compacted Collagen Gels

Maziar Aghvami; V. H Barocas; E. A Sander

doi:10.1115/1.4024460

Back

Multiscale Mechanical Simulations of Cell Compacted Collagen Gels

Journal article

Open access

Peer reviewed

Multiscale Mechanical Simulations of Cell Compacted Collagen Gels

Maziar Aghvami, V. H Barocas and E. A Sander

Journal of biomechanical engineering, Vol.135(7), pp.71004-71004

07/01/2013

DOI: 10.1115/1.4024460

PMCID: PMC3705867

PMID: 23720151

Files and links (1)

url

https://doi.org/10.1115/1.4024460View

Published (Version of record) Open Access

Abstract

Engineered tissues are commonly stretched or compressed (i.e., conditioned) during culture to stimulate extracellular matrix (ECM) production and to improve the mechanical properties of the growing construct. The relationships between mechanical stimulation and ECM remodeling, however, are complex, interdependent, and dynamic. Thus, theoretical models are required for understanding the underlying phenomena so that the conditioning process can be optimized to produce functional engineered tissues. Here, we continue our development of multiscale mechanical models by simulating the effect of cell tractions on developing isometric tension and redistributing forces in the surrounding fibers of a collagen gel embedded with explants. The model predicted patterns of fiber reorganization that were similar to those observed experimentally. Furthermore, the inclusion of cell compaction also changed the distribution of fiber strains in the gel compared to the acellular case, particularly in the regions around the cells where the highest strains were found.

Details

Title: Subtitle: Multiscale Mechanical Simulations of Cell Compacted Collagen Gels
Creators: Maziar Aghvami - Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242
V. H Barocas - Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455
E. A Sander - Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242 e-mail
Resource Type: Journal article
Publication Details: Journal of biomechanical engineering, Vol.135(7), pp.71004-71004
DOI: 10.1115/1.4024460
PMID: 23720151
PMCID: PMC3705867
NLM abbreviation: J Biomech Eng
ISSN: 0148-0731
eISSN: 1528-8951
Language: English
Date published: 07/01/2013
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Orthopedics and Rehabilitation; Craniofacial Anomalies Research Center; Chemical and Biochemical Engineering
Record Identifier: 9984064571602771

Metrics

16 Record Views

40 Times Cited - Web of Science