Multiscale Model Predicts Tissue-Level Failure From Collagen Fiber-Level Damage

Mohammad F Hadi; Edward A Sander; Victor H Barocas

doi:10.1115/1.4007097

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Multiscale Model Predicts Tissue-Level Failure From Collagen Fiber-Level Damage

Journal article

Open access

Peer reviewed

Multiscale Model Predicts Tissue-Level Failure From Collagen Fiber-Level Damage

Mohammad F Hadi, Edward A Sander and Victor H Barocas

Journal of biomechanical engineering, Vol.134(9), pp.0910051-09100510

09/2012

DOI: 10.1115/1.4007097

PMCID: PMC3717320

PMID: 22938372

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https://doi.org/10.1115/1.4007097View

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Abstract

Excessive tissue-level forces communicated to the microstructure and extracellular matrix of soft tissues can lead to damage and failure through poorly understood physical processes that are multiscale in nature. In this work, we propose a multiscale mechanical model for the failure of collagenous soft tissues that incorporates spatial heterogeneity in the microstructure and links the failure of discrete collagen ﬁbers to the material response of the tissue. The model, which is based on experimental failure data derived from different collagen gel geometries, was able to predict the mechanical response and failure of type I collagen gels, and it demonstrated that a ﬁber-based rule (at the micro-meter scale) for discrete failure can strongly shape the macroscale failure response of the gel (at the millimeter scale). The model may be a useful tool in predicting the macro-scale failure conditions for soft tissues and engineered tissue analogs. In addition, the multiscale model provides a framework for the study of failure in complex ﬁber-based mechanical systems in general.

collagen

Research Papers

multiscale modeling

biomechanics

biomaterials

tissue failure

Details

Title: Subtitle: Multiscale Model Predicts Tissue-Level Failure From Collagen Fiber-Level Damage
Creators: Mohammad F Hadi - Department of Biomedical Engineering
Edward A Sander - Department of Biomedical Engineering
Victor H Barocas - Department of Biomedical Engineering
Resource Type: Journal article
Publication Details: Journal of biomechanical engineering, Vol.134(9), pp.0910051-09100510
DOI: 10.1115/1.4007097
PMID: 22938372
PMCID: PMC3717320
NLM abbreviation: J Biomech Eng
ISSN: 0148-0731
eISSN: 1528-8951
Publisher: American Society of Mechanical Engineers
Language: English
Date published: 09/2012
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Orthopedics and Rehabilitation; Craniofacial Anomalies Research Center; Chemical and Biochemical Engineering
Record Identifier: 9984064205602771

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