Multiscale image-based modeling and simulation of gas flow and particle transport in the human lungs

Ching-Long Lin; Merryn H Tawhai; Eric A Hoffman

doi:10.1002/wsbm.1234

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Multiscale image-based modeling and simulation of gas flow and particle transport in the human lungs

Journal article

Open access

Multiscale image-based modeling and simulation of gas flow and particle transport in the human lungs

Ching-Long Lin, Merryn H Tawhai and Eric A Hoffman

Wiley interdisciplinary reviews. Systems biology and medicine, Vol.5(5), pp.643-655

09/2013

DOI: 10.1002/wsbm.1234

PMCID: PMC3763693

PMID: 23843310

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Abstract

Improved understanding of structure and function relationships in the human lungs in individuals and subpopulations is fundamentally important to the future of pulmonary medicine. Image-based measures of the lungs can provide sensitive indicators of localized features, however to provide a better prediction of lung response to disease, treatment, and environment, it is desirable to integrate quantifiable regional features from imaging with associated value-added high-level modeling. With this objective in mind, recent advances in computational fluid dynamics (CFD) of the bronchial airways-from a single bifurcation symmetric model to a multiscale image-based subject-specific lung model-will be reviewed. The interaction of CFD models with local parenchymal tissue expansion-assessed by image registration-allows new understanding of the interplay between environment, hot spots where inhaled aerosols could accumulate, and inflammation. To bridge ventilation function with image-derived central airway structure in CFD, an airway geometrical modeling method that spans from the model 'entrance' to the terminal bronchioles will be introduced. Finally, the effects of turbulent flows and CFD turbulence models on aerosol transport and deposition will be discussed.

Biological Transport

Gases - metabolism

Models, Biological

Humans

Hydrodynamics

Pulmonary Disease, Chronic Obstructive - diagnostic imaging

Tomography, X-Ray Computed

Lung - diagnostic imaging

Lung - physiopathology

Pulmonary Disease, Chronic Obstructive - physiopathology

Details

Title: Subtitle: Multiscale image-based modeling and simulation of gas flow and particle transport in the human lungs
Creators: Ching-Long Lin - Mechanical and Industrial Engineering, University of Iowa, Iowa City, IA, USA
Merryn H Tawhai
Eric A Hoffman
Resource Type: Journal article
Publication Details: Wiley interdisciplinary reviews. Systems biology and medicine, Vol.5(5), pp.643-655
DOI: 10.1002/wsbm.1234
PMID: 23843310
PMCID: PMC3763693
NLM abbreviation: Wiley Interdiscip Rev Syst Biol Med
ISSN: 1939-5094
eISSN: 1939-005X
Publisher: United States
Grant note: R01-HL-094315 / NHLBI NIH HHS P30 ES005605 / NIEHS NIH HHS R01 HL094315 / NHLBI NIH HHS S10-RR-022421 / NCRR NIH HHS R01 HL112986 / NHLBI NIH HHS S10 RR022421 / NCRR NIH HHS
Language: English
Date published: 09/2013
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Mechanical Engineering; Internal Medicine
Record Identifier: 9984051989202771

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