Multiscale imaging and registration-driven model for pulmonary acinar mechanics in the mouse

Haribalan Kumar; Dragos M Vasilescu; Youbing Yin; Eric A Hoffman; Merryn H Tawhai; Ching-Long Lin

doi:10.1152/japplphysiol.01136.2012

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Multiscale imaging and registration-driven model for pulmonary acinar mechanics in the mouse

Journal article

Open access

Peer reviewed

Multiscale imaging and registration-driven model for pulmonary acinar mechanics in the mouse

Haribalan Kumar, Dragos M Vasilescu, Youbing Yin, Eric A Hoffman, Merryn H Tawhai and Ching-Long Lin

Journal of applied physiology (1985), Vol.114(8), pp.971-978

04/2013

DOI: 10.1152/japplphysiol.01136.2012

PMCID: PMC4073897

PMID: 23412896

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Abstract

A registration-based multiscale method to obtain a deforming geometric model of mouse acinus is presented. An intact mouse lung was fixed by means of vascular perfusion at a hydrostatic inflation pressure of 20 cmH(2)O. Microcomputed tomography (μCT) scans were obtained at multiple resolutions. Substructural morphometric analysis of a complete acinus was performed by computing a surface-to-volume (S/V) ratio directly from the 3D reconstruction of the acinar geometry. A geometric similarity is observed to exist in the acinus where S/V is approximately preserved anywhere in the model. Using multiscale registration, the shape of the acinus at an elevated inflation pressure of 25 cmH(2)O is estimated. Changes in the alveolar geometry suggest that the deformation within the acinus is not isotropic. In particular, the expansion of the acinus (from 20 to 25 cmH(2)O) is accompanied by an increase in both surface area and volume in such a way that the S/V ratio is not significantly altered. The developed method forms a useful tool in registration-driven fluid and solid mechanics studies as displacement of the alveolar wall becomes available in a discrete sense.

Computer Graphics

Animals

Computer Simulation

Mice, Inbred C57BL

Mice

Imaging, Three-Dimensional

Pulmonary Alveoli - diagnostic imaging

Radiographic Image Interpretation, Computer-Assisted

X-Ray Microtomography

Pulmonary Alveoli - blood supply

Models, Anatomic

Details

Title: Subtitle: Multiscale imaging and registration-driven model for pulmonary acinar mechanics in the mouse
Creators: Haribalan Kumar - Department of Mechanical and Industrial Engineering, The University of Iowa, Iowa City, IA 52242-1527, USA
Dragos M Vasilescu
Youbing Yin
Eric A Hoffman
Merryn H Tawhai
Ching-Long Lin
Resource Type: Journal article
Publication Details: Journal of applied physiology (1985), Vol.114(8), pp.971-978
DOI: 10.1152/japplphysiol.01136.2012
PMID: 23412896
PMCID: PMC4073897
NLM abbreviation: J Appl Physiol (1985)
ISSN: 8750-7587
eISSN: 1522-1601
Publisher: United States
Grant note: R01-HL-080285 / NHLBI NIH HHS P30 ES005605 / NIEHS NIH HHS R01-HL094315 / NHLBI NIH HHS R01-EB-005823 / NIBIB NIH HHS S10-RR019242 / NCRR NIH HHS R01 HL112986 / NHLBI NIH HHS S10-RR022421 / NCRR NIH HHS
Language: English
Date published: 04/2013
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Mechanical Engineering; Internal Medicine
Record Identifier: 9984051525902771

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