Journal article
Multisystem Dysregulation in Painful Temporomandibular Disorders
Journal of Pain, Vol.14(9), pp.983-996
09/2013
DOI: 10.1016/j.jpain.2013.03.011
PMCID: PMC3770463
PMID: 23721875
Abstract
Multiple physiological and psychological regulatory domains may contribute to the pathophysiology of pain in temporomandibular disorder (TMD) and other bodily pain conditions. The purpose of this study was to evaluate the relationship between multisystem dysregulation and the presence of TMD pain, as well as the presence of different numbers of comorbid pain conditions in TMD. Secondary data analysis was conducted in 131 non-TMD (without comorbid pain) controls, 14 TMD subjects without comorbid pain, 78 TMD subjects with 1 comorbid pain, and 67 TMD subjects with multiple comorbid pain conditions who participated in a TMD genetic study. Twenty markers from sensory, autonomic, inflammatory, and psychological domains were evaluated. The results revealed that 1) overall dysregulation in multiple system domains (OR [odds ratio] = 1.6, 95% confidence interval [CI] = 1.4–1.8), particularly in the sensory (OR = 1.9, 95% CI = 1.3–2.9) and the psychological (OR = 2.1, 95% CI = 2.1–2.7) domains, were associated with increased likelihood of being a painful TMD case; and 2) dysregulations in individual system domains were selectively associated with the increased odds of being a TMD case with different levels of comorbid persistent pain conditions. These outcomes indicate that heterogeneous multisystem dysregulations may exist in painful TMD subgroups, and multidimensional physiological and psychological assessments can provide important information regarding pathophysiology, diagnosis, and management of pain in TMD patients. The concurrent assessment of multiple physiological and psychological systems is critical to our understanding of the pathophysiological processes that contribute to painful TMD and associated comorbid conditions, which will ultimately guide and inform appropriate treatment strategies that address the multisystem dysregulation associated with complex and common persistent pain conditions.
Details
- Title: Subtitle
- Multisystem Dysregulation in Painful Temporomandibular Disorders
- Creators
- Hong Chen - Regional Center for Neurosensory Disorders, University of North Carolina–Chapel Hill, School of Dentistry, Chapel Hill, North CarolinaAndrea Nackley - Regional Center for Neurosensory Disorders, University of North Carolina–Chapel Hill, School of Dentistry, Chapel Hill, North CarolinaVanessa Miller - Regional Center for Neurosensory Disorders, University of North Carolina–Chapel Hill, School of Dentistry, Chapel Hill, North CarolinaLuda Diatchenko - Regional Center for Neurosensory Disorders, University of North Carolina–Chapel Hill, School of Dentistry, Chapel Hill, North CarolinaWilliam Maixner - Regional Center for Neurosensory Disorders, University of North Carolina–Chapel Hill, School of Dentistry, Chapel Hill, North Carolina
- Resource Type
- Journal article
- Publication Details
- Journal of Pain, Vol.14(9), pp.983-996
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.jpain.2013.03.011
- PMID
- 23721875
- PMCID
- PMC3770463
- ISSN
- 1526-5900
- eISSN
- 1528-8447
- Grant note
- DE016558; NS045685; PO1 NS045685-061 A; T32-DE017245; UO1-DE017018 / NIH/NIDCR
- Language
- English
- Date published
- 09/2013
- Academic Unit
- Preventive and Community Dentistry
- Record Identifier
- 9983917687102771
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